Volume 18 (2023)
Volume 17 (2022)
Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
GI, Liver & Pancreas Pathology
Evaluation of Circulating Leptin and Its Receptor (Ob-R) Tissue Expression in Colorectal Cancer, a Report From North of Iran

Masoume Mahmoudi-Nesheli; Reza Alizadeh-Navaei; Laleh Vahedi; Omolbanin Amjadi; Tarang Taghvaei; Iradj Maleki; Ramin Shekarriz; Arash Kazemi; Versa Omrani-Nava; Maryam Alizadeh-Forutan

Volume 18, Issue 3 , July 2023, , Pages 299-305


  Background & Objective: Leptin is an adipocyte-derived hormone with a critical role in energy balance. As demonstrated by previous investigations, leptin acts as a proliferative and angiogenic factor in cancer cells. However, results regarding its role in colorectal cancer are still inconclusive. ...  Read More

GI, Liver & Pancreas Pathology
Lymphovascular Invasion Evaluation by the CD31 Expression in Gastric Adenocarcinoma

Seyed Amir Miratashi Yazdi; Elham Nazar

Volume 18, Issue 2 , April 2023, , Pages 140-146


  Background & Objective: Lymphovascular tumoral invasion is a typical histopathological feature of gastric carcinomas and supports the recognition of high-risk patients for the recurrence. We aimed to study the CD31 expression in diverse subtypes of gastric carcinomas and to show its association with ...  Read More

GI, Liver & Pancreas Pathology
A Clinicopathological Study with Risk-Stratified Staging of Pediatric Hepatoblastoma: A 5-Year Experience from a Tertiary Cancer Center

Geetha V PATIL Oklay; Akina Prakash; Akshatha C; Ashwini Nargund; Libin Babu Cherian; Balu S; Arun Kumar A R

Volume 18, Issue 2 , April 2023, , Pages 165-172


  Background & Objective: Hepatoblastoma encompasses 1% of pediatric malignancies and is the most common liver malignancy in children. Ninety percent of cases are under 5 years of age. Clinical and pathological risk stratification forms a crucial role in determining the treatment strategy. This study ...  Read More

GI, Liver & Pancreas Pathology
Frequency of HER2 Expression, MMR Deficiency, and PI3KCA Mutation in Pretreated Surgical Specimens of Patients with Esophageal Squamous Cell Carcinoma in Iran Cancer Institute

Samaneh Salarvand; Farzaneh Bagheri; Mahsa Gholizadeh; Sima Sharifi; Pooneh Panahi; Ebrahim Esmati; Marzieh Lashkari; Amirmohsen Jalaeefar; Mohammad Shirkhoda; Reza Shahsiah; Reza Ghalehtaki

Volume 18, Issue 1 , January 2023, , Pages 96-103


  Background & Objective: Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for the molecular pathogenesis of esophageal squamous cell cancer (ESCC), the role and frequency of HER2 expression, MMR deficiency, and PI3KCA mutation are not well ...  Read More

GI, Liver & Pancreas Pathology
Gastric Xanthoma: A Rare Case Report

Pummi kumari; Ruchi Sinha; Nisha Khanna; Tanmoy Maji

Volume 18, Issue 1 , January 2023, , Pages 104-107


  Xanthomas are characterized by the presence of foamy lipid-laden macrophages. The gastrointestinal tract is an uncommon site for xanthoma, with the stomach being the most favored location. They have been associated with various premalignant and malignant conditions of the stomach. We present a case of ...  Read More

GI, Liver & Pancreas Pathology
Algorithmic Approach to Inflammatory Disorders of Ileum

Afshin Moradi; Ali Mokhtar pour; Amir Yazdani; Kianoosh Kianersi; Leila Bahari Khasraghi

Volume 17, Issue 4 , October 2022, , Pages 381-394


  The ileum undergoes endoscopic biopsy much more than before. Most of these biopsies are either completely normal or show non-specific changes. Nevertheless, in some diseases, ileal biopsy is diagnostic, and in some cases it may be the only anatomical location of the disease. Endoscopically normal mucosal ...  Read More

GI, Liver & Pancreas Pathology
A Rare Case of Cardiac Metastasis from Colon Cancer

Zahra Modabber; Roghayeh Pourkia; Hamidreza Vafaey; Ali Alizadeh; Mohammad Ranaei

Volume 17, Issue 4 , October 2022, , Pages 477-481


  It is very rare for colorectal neoplasms to metastasize to the heart in the worldwide medical literature; only a single case of well-documented colorectal cancer metastasis to the left atrium was found. The case of a 66-year-old man is explained in this paper, who was suffering from metastatic adenocarcinoma ...  Read More

GI, Liver & Pancreas Pathology
Immunohistochemical Expression of CDX2 in Gastric Carcinoma

Avan Sardar Ahmed; Jalal Ali Jalal; Kalthuma Salih Hamad Ameen

Volume 17, Issue 2 , April 2022, , Pages 143-149


  Background & Objective: Gastric cancer (GC) persists to be a major health issue globally, and the need to investigate new molecular markers for improving the survival of patients continues. CDX2 is a homeobox caudal protein family member encoded by the CDX2 gene and is probably playing a role in ...  Read More

GI, Liver & Pancreas Pathology
Clinicopathological Significance of PTEN Expression and Its Prognostic Effect in Colorectal Adenocarcinoma Patients

Zohreh Mirzapour Abbas abadi; Fatemeh Samiee Rad; Dariush Hamedi Asl; Babak Rahmani; Mahmood Soleimani Dodaran; Amir Peimani

Volume 17, Issue 2 , April 2022, , Pages 150-158


  Background & Objective: Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene located at chromosome 10. PTEN is a regulator of the PI3K/AKT signaling pathway that inhibits cell proliferation and promotes apoptosis. PTEN loss of function occurs in a spectrum  of cancers, including ...  Read More

GI, Liver & Pancreas Pathology
Quantity and Distribution of Eosinophils in the Adult Human Gastric Specimens

Behrang Kazeminezhad; Helia Falahatian Mehrjardi; Afshin Moradi; Tahmineh Mollasharifi

Volume 17, Issue 2 , April 2022, , Pages 166-173


  Background & Objective: The existence of eosinophils in the gastric mucosal epithelium is unusual, while the term "eosinophilic gastritis" has become overused due to the increased numbers of eosinophils found in gastric specimens. Thus, we aimed to assess the number and distribution of eosinophils ...  Read More

GI, Liver & Pancreas Pathology
Immunohistochemical Expression of Stanniocalcin 2 in Colorectal Cancer: A Retrospective Egyptian Study

Hala M. El-hanbuli; Rehab S. Galal; Mohammed F. Darweesh; Mohamed H. Elmahdi

Volume 17, Issue 1 , January 2022, , Pages 15-22


  Background & Objective: Colorectal cancer is the third most common cause of cancer death worldwide. Stanniocalcin 2 (STC2) is a glycoprotein hormone over-expressed in many human cancers where it regulates tumor progression and invasion. Evaluating its expression in colorectal cancer and its relation ...  Read More

GI, Liver & Pancreas Pathology
Kindlin1 As a Sex and Location Specific Diagnostic Marker in Gastric Cancer Patients

Mohammad Reza Abbaszadegan; Negin Taghehchian; Azadeh Aarabi; Sohrab Nozari; Ehsan Saburi; Meysam Moghbeli

Volume 17, Issue 1 , January 2022, , Pages 23-28


  Background & Objective: Gastric cancer (GC) is considered one of the main reasons for cancer-related mortalities among Iranians. Kindlin-1 is an adhesion protein member of integrin-interacting proteins, regulating integrin activation through direct interaction with β-integrin. Therefore, kindlin-1 ...  Read More

GI, Liver & Pancreas Pathology
LncRNA SNHG6 Silencing Could Arrest Progression of High Grade Colorectal Cancers

Amin Jafari Oliayi; Shahriar dabiri; Malek Hossein Asadi

Volume 17, Issue 1 , January 2022, , Pages 29-36


  Background & Objective: Colorectal cancer (CRC), like other cancers, needs faster and more accurate identifications. A well-timed prognosis of CRC could be an important turning point in the survival of patients. Supplementary signs, such as long non-coding RNAs (lncRNAs), could be helpful for this ...  Read More

GI, Liver & Pancreas Pathology
Annexin Expression in Cholangiocarcinoma, and Metastatic Pancreatic Ductal Adenocarcinoma “Is it be Helpful for Differential Diagnosis of These Tumors in the Liver?”

Bita Geramizadeh; Mahsa Sehat; Azam Mehrmozayan; Alireza Shojazadeh

Volume 16, Issue 4 , August 2021, , Pages 433-438


  Background & Objective: Differential diagnosis between cholangiocarcinoma (CCA) and metastatic pancreatic ductal adenocarcinoma (PDA) in the liver is difficult and so far, no specific immunohistochemical marker is reported to differentiate these two tumors. Considering the existing literature, the ...  Read More

GI, Liver & Pancreas Pathology
The Outcome of Induction Chemotherapy, Followed by Neoadjuvant Chemoradiotherapy and Surgery, in Locally Advanced Rectal Cancer

Ali Yaghobi Joybari; Behnaz Behzadi; Payam Azadeh; Sam Alahyari

Volume 16, Issue 3 , July 2021, , Pages 266-273


  Background & Objective: Currently, neoadjuvant chemoradiotherapy, followed by surgery, is the standard treatment for locally advanced rectal cancer. The use of induction chemotherapy for this tumor is controversial. In this study, the benefits and side effects of induction chemotherapy in locally ...  Read More

GI, Liver & Pancreas Pathology
Microsatellite Instability and Colorectal Cancer, Immunohistochemical and Molecular Evaluation by Using DNA Sequencing: A Single Center Experience

Bita Geramizadeh; Farzaneh Bozorg-Ghalati; Firoozeh Jafari; Mitra Mirzai; Zahra Jowkar

Volume 16, Issue 3 , July 2021, , Pages 325-331


  Background & Objective: Microsatellite instability is common in familial colorectal cancers. It can be tested by the molecular and immunohistochemical methods. There are very few studies which address comparing the clinicopathological characteristics of microsatellite stable (MSS) and microsatellite ...  Read More

GI, Liver & Pancreas Pathology
Candidate Molecular Biomarkers for the Non- Invasive Detection of Colorectal Cancer using Gene Expression Profiling

Mohammad Shafiei; Mahdi Alemrajabi; Ali Najafi; Amirhomayoon Keihan; Masoudreza Sohrabi

Volume 16, Issue 2 , April 2021, , Pages 203-212


  Background and Objective: Colorectal Cancer (CRC) is the third most common cancer after prostate (breast in women) and lung cancer; it is also the third cause of cancer deaths reported in both men and women in 2020. Currently, the most commonly used diagnostic tools for CRC are colonoscopy, serological ...  Read More

GI, Liver & Pancreas Pathology
Clinicopathological Significance of Tumor Stem Cell Markers ALDH1 and CD133 in Colorectal Carcinoma

maryam Rezaee; Elmira Gheytanchi; Zahra Madjd; Mitra Mehrazma

Volume 16, Issue 1 , January 2021, , Pages 40-50


  Background & Objective: Colorectal cancer (CRC) is the third most common cancer worldwide with a high mortality rate. The main causes of death in patients are recurrence and metastasis which are mainly attributed to the small subpopulation of cells within tumors called cancer stem cells (CSCs). This ...  Read More

GI, Liver & Pancreas Pathology
Assessment of p16 and Ki67 Immunohistochemistry Expression in Squamous Intraepithelial Lesion with Cytohistomorphological Correlation

Apurv Ghosh; M Nirupama; Nandan Padmanabha; Hema Kini

Volume 15, Issue 4 , October 2020, , Pages 268-273


  Background & Objective: Cervical cancer is the most common cancer in women worldwide with high mortality, necessitating quicker diagnostic methods. We wish to enhance the existing cervical biopsies of Squamous Intraepithelial Lesions (SIL) using p16 and Ki67 as surrogate markers to assess correlation ...  Read More

GI, Liver & Pancreas Pathology
Orthotopic Liver Transplantation for Etanercept-Induced Acute Hepatic Failure; a case report

Dorsay Sadeghian; Farid Azmoudeh-Ardalan; Simin Dashti-Khavidaki; Nasir Fakhar

Volume 15, Issue 4 , October 2020, , Pages 338-341


  The occurrence of hepatotoxicity following etanercept (tumor necrosis factor-alpha antagonist) prescription, has been studied well. However, an acute hepatic failure leading to liver transplant as an adverse effect of this drug has not been reported in the literature. In this article, we are going to ...  Read More

GI, Liver & Pancreas Pathology
Interobserver Agreement in Assessing Dysplasia in Colorectal Adenomatous Polyps: A Multicentric Iranian Study

Tahmineh Mollasharifi; Mahsa Ahadi; Elena Jamali; Afshin Moradi; Parisa Asghari; Saman Maroufizadeh; Behrang Kazeminezhad

Volume 15, Issue 3 , July 2020, , Pages 167-174


  Background & Objective: Most colorectal cancers (CRCs) arise from adenomatous polyps, and clinical management of this type of polyp is highly dependent on the reliability and validity of the pathological diagnosis. The aim of this study was to examine the interobserver agreement of five pathologists ...  Read More

GI, Liver & Pancreas Pathology
Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma

Shilpa Tukaram Patil; Clement Wilfred Devadass; Prasanna Shetty Badila

Volume 14, Issue 4 , October 2019, , Pages 317-321


  Background & Objective: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, ...  Read More

GI, Liver & Pancreas Pathology
Inter-observer Variability in Histomorphological Evaluation of Non-neoplastic Liver Biopsy Tissue and Impact of Clinical Information on Final Diagnosis in Shahid Beheshti University of Medical Sciences Affiliated Hospitals

Zeinab Kishani farahani; Mahsa Ahadi; Behrang Kazeminejad; Tahmineh Mollasharifi; Malihe Saber Afsharian; Amir Sadeghi; Farahnaz Bidari zerehpoosh; Elena Jamali; Niki Hasanzadeh; Abolfazl Movafagh; Arash Dehghan; Arsham Moradi; Afshin Moradi

Volume 14, Issue 3 , August 2019, , Pages 243-251


  Background & Objective: Liver biopsy is the main method for grading and staging liver disorders, but the effects of clinical information and optimal biopsy specimen size on interpretation remain contentious. The aim of the study was to evaluate the impact of clinical information and quality of liver ...  Read More

GI, Liver & Pancreas Pathology
Heterotopic Pancreas as a Leading Point of Intussusception: A Case Report

Hiva Saffar; Seyed Mohammad Tavangar; Salma Sefidbakht; Roghayeh Aghapour; Fatemeh Molavi

Volume 14, Issue 2 , April 2019, , Pages 180-183


  Heterotopic pancreas (HP) is generally asymptomatic and found incidentally. It can act very rarely as a leading point for intussusception. Thus, it should be considered as a differential diagnosis of the mass lesions leading to the intestinal intussusception. Herein, we report an unusual case of HP as ...  Read More

GI, Liver & Pancreas Pathology
The Correlation between Serum Zinc Level and Liver Histology in Non-Alcoholic Steatohepatitis

Farid Kosari; Raika Jamali; Tayeb Ramim; Ebrahim Musavi Jahan Abad

Volume 14, Issue 1 , January 2019, , Pages 17-25


  Background & Objective: The aim of this present study was to assess the relationship between serum zinc levels and liver histopathological findings in non-alcoholic steatohepatitis (NASH) patients.Methods: This case-control study was performed in consecutively selected NASH patients who had been ...  Read More