Iranian Journal of Pathology

Histopathologic and Prognostic Significance of Tumor Budding in Colorectal Adenocarcinoma: A Retrospective Cohort Study Conducted in Shiraz, Iran

Document Type : Original Research

Authors

Mohammad Hossein Anbardar 1
Nadia Rahimizadeh 2

1 Department of Pathology, Namazi Teaching Hospital, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.30699/ijp.2023.1999329.3090
Abstract
Background & Objective: Colorectal cancer is the second reason for cancer-associated death. The prognosis of the malignancy is defined by TNM scoring. However, tumor grading, lymphovascular invasion, perineural invasion, and tumor buddings may affect its prognosis. This study aimed to assess the prognostic and histologic impact of tumor budding in colorectal adenocarcinoma.
Methods: This study is a retrospective cohort of 192 patients with colorectal adenocarcinoma. All four stages of colorectal adenocarcinoma patients were included, but the patients in stages I and II were also analyzed separately. We used pathology reports to extract the histopathologic data. The prognostic values were extracted by calling the patients.
Results: Less than half of the patients were in stages I and II of the disease. According to our analysis, tumor extension and lymphovascular invasion were correlated with tumor budding count in patients in stages I and II, and lymphovascular invasion, tumor grade, tumor stage, lymph node involvement, tumor extension, tumor site, metastasis, and five-year survival were correlated with tumor budding within all stages.
Conclusion: It is recommended that tumor budding count should be assessed and reported in pathology reports of adenocarcinomas due to its high correlation with poor prognosis.

Keywords

Neoplasms
Neoplasm Metastasis
Survival Rate
Recurrence

Subjects

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Iranian Journal of Pathology
Volume 19, Issue 1
Winter 2024
Pages 59-66

  • Receive Date 01 April 2023
  • Revise Date 20 August 2023
  • Accept Date 20 August 2023

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