Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Number of Volumes 17
Number of Issues 69
Number of Articles 894
Number of Contributors 2,872
View Per Article 1592.16
PDF Download Per Article 897.26
Number of Submissions 2,061
Number of Indexing Databases 49
Number of Reviewers 684

Iranian Journal of Pathology (Iran J Pathol)

Quarterly Journal of Anatomical and Clinical Pathology

The IRANIAN JOURNAL OF PATHOLOGY (IJP),  is an Open Access journal and publishes original research papers, reviews, case reports, short communications, and letters to the editor with priority for high-quality original papers on mechanisms of disease and clinical trials. We accept manuscripts that report important findings on disease pathogenesis and basic biological mechanisms that relate to disease without preferences for a  specific method of analysis. High priority is given to studies on human diseases and relevant experimental models that use cellular, molecular, biochemical & immunological approaches in conjunction with morphology, and to manuscripts that report new diagnostic methods or analytical systems and their application in studies of disease pathogenesis and diagnosis.   


  • Bone and Soft Tissue Pathology,
  • Dermatopathology,
  • Biochemistry,
  • Biology & Genetic,
  • Infectious Diseases,
  • Microbiology,
  • GI pathology & Hepatopathology,
  • Endocrine Pathology,
  • ENT & Ophthalmic Pathology,
  • Gynecologic & Breast Pathology,
  • Molecular Pathology,
  • Nephropathology,
  • Neuropathology,
  • Neuroscience and Anatomy,
  • Oncology & Hematology,
  • Oral Pathology,
  • Pediatric Pathology,
  • Surgical Pathology,
  • Diagnostic Pathology,
  • Uropathology




Review Article GI, Liver & Pancreas Pathology
Algorithmic Approach to Inflammatory Disorders of Ileum

Afshin Moradi; Ali Mokhtar pour; Amir Yazdani; Kianoosh Kianersi; Leila Bahari Khasraghi

Volume 17, Issue 4 , October 2022, Pages 381-394


  The ileum undergoes endoscopic biopsy much more than before. Most of these biopsies are either completely normal or show non-specific changes. Nevertheless, in some diseases, ileal biopsy is diagnostic, and in some cases it may be the only anatomical location of the disease. Endoscopically normal mucosal ...  Read More

Review Article Molecular Pathology
Genetic and Epigenetic Alterations in Parathyroid Neoplasms

Seyed Amir Miratashi Yazdi; Elham Nazar

Volume 17, Issue 4 , October 2022, Pages 395-405


  The etiology of parathyroid carcinoma (PC) is largely unknown. Associations have been made with several inherited syndromes and with specific genetic lesions. The management of PC is challenging for clinicians. The complexity of molecular phenotypes increases with tumor aggressiveness. Lack of parafibromin ...  Read More

Original Research Cardiovascular Pathology
Assessment of Neutrophil Extracellular Traps (NETs) and Macrophage Ratio in the Inner and Outer Area of Carotid Artery Stenosis

Shirin Saberianpour; Mohammad Mahdi Saeed Modaghegh; Mohammad Mahdi Kamyar

Volume 17, Issue 4 , October 2022, Pages 406-412


  Background & Objective: It is noteworthy that vast data links NETs to human arterial thrombosis. In the current study, extracellular neutrophil networks and macrophage polarization were assessed in the area outside and inside the Carotid artery stenosis.Methods: The sample of Carotid plaque of the ...  Read More

Original Research Breast Pathology
Preoperative Neutrophil: Lymphocyte Ratio, Platelet: Lymphocyte Ratio, and C-Reactive Protein Levels Predictive Value in Determining the Severity of Breast Mass

Aida Alizamir; Sakineh Dehghan Azad; Azar Pirdehghan; Arash Moradi

Volume 17, Issue 4 , October 2022, Pages 413-418


  Background & Objective: Female breast cancer is one of the most prevalent malignancies among women. The critical step in managing breast cancer is to diagnose it accurately. Hence, peripheral blood-based tests are one of the most favorable and less invasive methods to study. Recent studies investigated ...  Read More

Original Research Hematopathology
Evaluation of FLT3-ITD Mutations and MDR1 Gene Expression in AML Patients

ehsan yazdandoust; mohammad hadidi sadeghian; seyyede fatemeh shams; Yasaman Saadatpour; payam siyadat; maryam sheikhi; Monavar Afzal Aghaee; Hossein Ayatollahi

Volume 17, Issue 4 , October 2022, Pages 419-426


  Background & Objective: Acute myeloid leukemia (AML) is a hematopoietic malignancy caused by genetic abnormalities. These days, molecular and genetic factors are usually used as diagnostic and prognostic markers. FLT-3 is one of the most known diagnostic factors in AML. MDR1 gene belongs to the ATP ...  Read More

Original Research Endocrine Pathology
Thyroid Stimulating Hormone, T3 and T4 Population-based Reference Range and Children Prevalence of Thyroid Dysfunction: First Report from South of Iran

Mansoureh Shokripour; Mohammad Hadi Imanieh; Saghar Garayemi; Navid Omidifar; Babak Shirazi Yeganeh; Fadhil Althabhawee

Volume 17, Issue 4 , October 2022, Pages 427-434


  Background & Objective: The TSH reference range's validity affects the thyroid dysfunction diagnosis. The primary objective of this study is to determine the reference range, which is established according to age and region.Methods: The data were collected retrospectively from people over the age ...  Read More

Original Research Breast Pathology
Breast Carcinoma – A Comparative Study of Immunohistochemistry and Fluorescence in Situ Hybridization for Her-2 Assessment and Association of ER, PR, HER-2 and Ki-67 Expression with Clinico-Pathological Parameters

Sajitha K; Meenakshi Arumugam; Jayaprakash Shetty; Reshma A Shetty; Ritu Asnani; Prashanth Shetty

Volume 17, Issue 4 , October 2022, Pages 435-442


  Background & Objective: Breast cancer is the most common cancer in developed and developing countries. This study mainly addresses the issue of an equivocal result in IHC, which then needs further assessment if the patient has to receive targeted therapy. The study aimed to detect the expression ...  Read More

Original Research Endocrine Pathology
Evaluation of Positive Predictors of Micrometastasis in Central Lymph Nodes in Patients with Papillary Thyroid Cancer; A Cross-Sectional Study

Hamid Asherloo; Seyed Ali Nabipoorashrafi; Atefeh Kashanizadeh; Mohammad Moradi; Majid Rezaei Tavirani; Massoud Baghai wadji

Volume 17, Issue 4 , October 2022, Pages 442-447


  Background & Objective: Papillary thyroid cancer (PTC) is the most common primary cancer originating from thyroid follicular cells. The aim of this study was to evaluate the positive predictors of micrometastasis in central lymph nodes in patients with papillary thyroid cancer. Methods: This was ...  Read More

Original Research Immunology and Serology
Comparison of Immune Response in Mice Immunized with Recombinant PreS2/S-C18-27 Protein Derived from Hepatitis B Virus with Commercial Vaccine

Elaheh Gholami Parizad; Abbas Ali Imani Fooladi; Hamid Sedighian; Elham Behzadi; Azar valizadeh; Afra Khosravi

Volume 17, Issue 4 , October 2022, Pages 448-460


  Background & Objective: The vaccine available to prevent Hepatitis B virus disease is ineffective in 5% of people due to the use of HBsAg as a weak immunogen. In the present study, PreS2/S fused to C18-27 peptide fragment as an effective antigen and is proposed as a promising vaccine candidate compared ...  Read More

Original Research Infectious Diseases
Topical Treatment of Second-Degree Burn Wounds with Lactobacillus plantarum Supernatant: Phase I Trial

Somayeh Soleymanzadeh Moghaddam; Mahnoush Momeni; Samaneh Mazar Atabaki; Tahereh Mousavi Shabestari; Mina Boustanshenas; Mastaneh Afshar; Maryam Roham

Volume 17, Issue 4 , October 2022, Pages 460-468


  Background & Objective: A burn wound is sterile immediately after injury, but opportunistic bacteria colonize the wound within 48 to 72 hours after the burn, causing delayed or failed burn wound healing. In addition, the presence of multidrug-resistant (MDR) pathogens doubles the treatment problems. ...  Read More

Original Research Oral Pathology
KRAS Protein Expression in Oral Squamous Cell Carcinoma: A Potential Marker for Progression and Prognosis

Hala M. El-hanbuli; Mostafa A. Abou Sarie

Volume 17, Issue 4 , October 2022, Pages 464-474


  Background & Objective: Emerging evidence suggests that KRAS could play an important role in squamous cell carcinoma; however, its role in oral squamous cell carcinoma (OSCC) is largely unknown. The aim of the current study was to investigate the expression of KRAS, Ki-67, Cyclin D1, and Bcl2 in ...  Read More

Original Research Breast Pathology
Exploring the Integrated Role of AKT2, CD44v6, And MT1-MMP as Predictors of Axillary Lymph Node Metastasis in Invasive Breast Carcinoma of No Special Type

Primariadewi Rustamadji; Elvan Wiyarta; Kristina Anna Bethania

Volume 17, Issue 4 , October 2022, Pages 475-485


  Background & Objective: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer, which mainly causes axillary lymph-node metastasis (ALNM). Building on our previous research, we wanted to explore the optimal combination of AKT2, CD44v6, and MT1-MMP for the ...  Read More

Case Reports GI, Liver & Pancreas Pathology
A Rare Case of Cardiac Metastasis from Colon Cancer

Zahra Modabber; Roghayeh Pourkia; Hamidreza Vafaey; Ali Alizadeh; Mohammad Ranaei

Volume 17, Issue 4 , October 2022, Pages 477-481


  It is very rare for colorectal neoplasms to metastasize to the heart in the worldwide medical literature; only a single case of well-documented colorectal cancer metastasis to the left atrium was found. The case of a 66-year-old man is explained in this paper, who was suffering from metastatic adenocarcinoma ...  Read More

Case Reports Nephropathology
Crescentic Glomerulonephritis, A Rare Presentation of Alport Syndrome

Tahereh Malakoutian; Fatemeh Nili; Sholeh Ghasemi Darbrood; Samaneh Salarvand; Mitra Mehrazma

Volume 17, Issue 4 , October 2022, Pages 496-499


  Crescentic glomerulonephritis (GN) is a feature of severe glomerular injury. Anti-GBM disease, immune-complex mediated glomerulonephritis, and ANCA-associated vasculitis are the main causes of crescentic GN. Alport syndrome is a progressive form of hereditary nephritis presenting with hematuria and progression ...  Read More

The Role of Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma

Roshanak Ghaffarian Zirak; Hurie Tajik; Jahanbakhsh Asadi; Pedram Hashemian; Hossein Javid

Volume 17, Issue 2 , April 2022, , Pages 122-136


  Glioblastoma is a type of brain cancer with aggressive and invasive nature. Such features result from increased proliferation and migration and also poor apoptosis of glioma cells leading to resistance to current treatments such as chemotherapy and radiotherapy. In recent studies, micro RNAs have been ...  Read More

Changes of Routine Hematological Parameters in COVID-19 Patients: Correlation with Imaging Findings, RT-PCR and Outcome

Abdolreza Javadi; Shahriar Dabiri; Manzumeh Shamsi Meymandi; Mohammad Hashemi-Bahremani; Hussein Soleimantabar; Bahram Dabiri; Houman Vosough; Maryam Gheidi Sharan; Farnoosh Sedaghati

Volume 17, Issue 1 , January 2022, , Pages 37-47


  Background & Objective: Coronavirus disease 2019 (COVID-19) is progressively spreading, and many researchers have focused on the prognostic value of laboratory analyses. This study reviewed routine blood parameters, upper respiratory viral load, and chest imaging in recovered and expired COVID-19 ...  Read More

The Epidemiological, Clinical, Mycological, and Pathological Features of Rhino-cerebral Mucormycosis: A Systematic Review

Mohammadreza Salehi; Shahram Mahmoudi; Omid Rezahosseini; Sayed Jamal Hashemi; Kazem Ahmadikia; Farzad Aala; Nasim Khajavirad; Neda Alijani; Alireza Izadi; Muhammad Ibrahim Getso; Alireza Abdollahi; Arezoo Salami; Seyedeh Rana Khatami; Alireza Adibimehr; Mojtaba Hedayat Yaghoobi; Mohammadmahdi Sabahi; Behshad Pazooki; Farhad Yazdi; Jayran Zebardast; Arash Seifi; Malihe Hasan Nezhad; Masoud Mardani; Sadegh Khodavaisy

Volume 17, Issue 2 , April 2022, , Pages 112-121


  Cerebral mucormycosis (CM) is a life-threatening manifestation of mucormycosis, an angioinvasive fungal infection caused by Mucorales. We sought to systematically review all available case reports to describe epidemiologic features, clinical manifestations, predisposing factors, and diagnostic and treatment ...  Read More

Infectious Diseases
Effects of Human Nucleolus Upon Guest Viral-Life, Focusing in COVID-19 Infection: A Mini- Review

Moslem Bahadori; Mohammad Hossein Azizi; Shahriar Dabiri; Neda Bahadori

Volume 17, Issue 1 , January 2022, , Pages 1-7


  The nucleolus is a subcellular membraneless structure of eukaryotic cells. In 1965, in a world’s southern summer summit in Uruguay, the role of the nucleolus as the site of ribosome synthesis, biogenesis, and processing of tRNA was conclusively established. Today, accumulating evidence confirm ...  Read More

Endocrine Pathology
Synchronous Occurrence of Papillary Thyroid Carcinoma and Medullary Carcinoma in Hashimoto’s Thyroiditis and Multi Nodular Goiter Background

Fatemeh Samiee Rad; Ali Emami

Volume 17, Issue 1 , January 2022, , Pages 91-96


  Background & Objective: Coexistence of follicular epithelial and bilateral parafollicular cells derivative of carcinomas in Hashimoto’s thyroiditis and multinodular goiter background are a very rare event. Of course, all benign and malignant thyroid lesions are more prevalent in iodine deficient ...  Read More

Role of Aders and OXA23 Genes among Imipenem Resistant Acinetobacter baumannii Isolates from Two Hospitals of Tehran, Iran

Helia Ostad Asadolah-Malayeri; Mojdeh Hakemi-Vala; Kambiz Davari

Volume 11, Issue 4 , October 2016, , Pages 345-353

  Background: This study aimed to evaluate the role of efflux pump regulator and OXA-23 genes in imipenem resistance Acinetobacter baumannii strains isolated from hospitalized patients in Tehran, Iran. Methods: This study was conducted on 60 A. baumannii isolates collected from patients admitted to the ...  Read More

Diagnostic Value of Measurement Specific Gravity by Refractometric and Dipstick Method in Differentiation between Transudate and Exudate in Pleural and Peritoneal Fluid

Alireza Abdollahi; Zoreh Nozarian

Volume 11, Issue 4 , October 2016, , Pages 363-369

  Background: Accumulation of pleural and peritoneal fluid is seen in some diseases. In order to diagnose the disease and start the treatment, one of the most important actions will be to differentiate between exudates and transudates. The objective of this study was to determine the diagnostic value of ...  Read More

Evaluation of Different Phenotypic and Genotypic Methods for Detection of Methicillin Resistant Staphylococcus aureus (MRSA)

Hossein Koupahi; Sahar Honarmand Jahromy; Mohammad Rahbar

Volume 11, Issue 4 , October 2016, , Pages 370-376

  Background: Methicillin resistant Staphylococcus aureus (MRSA) has been emerged as a nosocomial and community acquired pathogen worldwide. There are many challenges for laboratory detection of MRSA. The aim of this study was to compare different phenotypic methods with PCR based method as a gold standard ...  Read More

Correlation of P16 (Ink4a) and CK17 to HPV (16E6+18E6) in Premalignant and Malignant Lesions of Uterine Cervix: A Clinicopathologic Study

Mohammed Chaloob; Alaa G. Hussein; Ban Qasim

Volume 11, Issue 4 , October 2016, , Pages 377-390

  Background: This research was accomplished to evaluate the IHC expression of p16 (ink4a) and CK17 in low grade cervical intraepithelial lesions (LSIL), high grade cervical intraepithelial lesions (HSIL) and invasive cervical carcinomas and to assess their correlation to HPV (16E6+18E6). Methods: The ...  Read More

Predictive Values of Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin for Delayed Graft Function Diagnosis in Kidney Transplantation

Mojtaba Mojtahedzadeh; Farhad Etezadi; Javad Motaharinia; Alireza Abdollahi; Abdorasul Mehrsai; Shadi Ziaie; Soheil Saadat

Volume 11, Issue 4 , October 2016, , Pages 391-398

  Background: Delayed graft function is a main complication after deceased donor kidney transplantation that adversely affects graft outcome. Difficulties in prediction and early detection of delayed graft function have hindered the ability to perform proper therapeutic interventions. We investigated whether ...  Read More


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