Iranian Journal of Pathology

Clinicopathological Significance of PTEN Expression and Its Prognostic Effect in Colorectal Adenocarcinoma Patients

Document Type : Original Research

Authors

Zohreh Mirzapour Abbas abadi 1
Fatemeh Samiee Rad 2
Dariush Hamedi Asl 3
Babak Rahmani 1
Mahmood Soleimani Dodaran 4
Amir Peimani 5

1 Department of Molecular Medicine, Faculty of Medical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran

2 Department of Pathology, Faculty of Medical School, Qazvin University of Medical Sciences, Qazvin, Iran

3 Department of Pathology and Molecular Medicine, Mehr Laboratory, Hashtgerd, Iran

4 Qazvin University of Medical Sciences

5 Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

https://doi.org/10.30699/ijp.2021.531779.2653
Abstract
Background & Objective: Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene located at chromosome 10. PTEN is a regulator of the PI3K/AKT signaling pathway that inhibits cell proliferation and promotes apoptosis. PTEN loss of function occurs in a spectrum  of cancers, including colorectal adenocarcinoma. This study aimed to investigate the probable correlation of negative PTEN expression with clinicopathological features and colorectal adenocarcinoma (CRC) patients'''' survival.
Methods: In this cross-sectional study using Immunohistochemistry stainingPTEN expression status on 151 CRC tissues was evaluated. Then the results of IHC staining was compared to those of clinicopathological features. The relationship between PTEN and KRAS mutation status was also investigated.
Results: Of 151 CRC samples, 89 (58.9%) were negative for PTEN expression. Loss of PTEN expression was associated with KRAS mutation (P

Keywords

Adenocarcinoma
Clinicopathology
Colorectal cancer
PTEN
Prognostic factors

Subjects

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Iranian Journal of Pathology
Volume 17, Issue 2
Spring 2022
Pages 150-158

  • Receive Date 07 June 2021
  • Revise Date 28 November 2021
  • Accept Date 01 December 2021

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