Iranian Journal of Pathology

Lymphovascular Invasion Evaluation by the CD31 Expression in Gastric Adenocarcinoma

Document Type : Original Research

Authors

Seyed Amir Miratashi Yazdi 1
Elham Nazar 2

1 Department of general surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

2 Department of pathology, Sina hospital, Tehran University of Medical Sciences, Tehran, Iran

https://doi.org/10.30699/ijp.2023.562466.2977
Abstract
Background & Objective: Lymphovascular tumoral invasion is a typical histopathological feature of gastric carcinomas and supports the recognition of high-risk patients for the recurrence. We aimed to study the CD31 expression in diverse subtypes of gastric carcinomas and to show its association with the histopathologic findings of the carcinoma to assess the prognosis.
Methods: This cross-sectional study was conducted on 40 established patients of gastric adenocarcinoma from radical gastrectomy. The patients were classified according to the pathology assessments. Tumoral tissues were assessed by immunohistochemical staining for the CD31 expression. Malignant behavior was estimated by the histopathological evaluations.
Results: CD31 positivity was described in 23 (57.5%) of all evaluated patients. The assessment of CD31 expression and tumor features presented no significant association between the CD31 expression and patients’ age, sex, tumor site,  size, grade and stage, subtypes of carcinoma, perineural invasion, and also lymphovascular invasion (P>0.05).
Conclusion: Lymphovascular invasion makes valuable additional evidence that might be useful to detect gastric carcinoma patients at high risk for the recurrence, who could be candidates for more supplementary therapies. However, in our society, the CD31 expression did not show any association with the aggressive histopathologic features of this tumor.

Keywords

CD31
Gastric carcinoma
Lymphovascular invasion
Recurrence

Subjects

  1. Li P, He HQ, Zhu CM, Ling YH, Hu WM, Zhang XK, et al. The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China. BMC Cancer. 2015;15(1):370. [DOI:10.1186/s12885-015-1370-2] [PMID] [PMCID]
  2. Gresta LT, Rodrigues-Junior IA, de Castro LP, Cassali GD, Cabral MM. Assessment of vascular invasion in gastric cancer: a comparative study. World J Gastroenterol. 2013;19(24):3761-9. [DOI:10.3748/wjg.v19.i24.3761] [PMID] [PMCID]
  3. Chakroborty D, Sarkar C, Mitra RB, Banerjee S, Dasgupta PS, Basu S. Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis. Clin Cancer Res. 2004;10(13):4349-56. [DOI:10.1158/1078-0432.CCR-04-0059] [PMID]
  4. Kim JH, Park SS, Park SH, Kim SJ, Mok YJ, Kim CS, et al. Clinical significance of immunohistochemically-identified lymphatic and/or blood vessel tumor invasion in gastric cancer. J Surg Res. 2010;162(2):177-83. [DOI:10.1016/j.jss.2009.07.015] [PMID]
  5. Kinami S, Saito H, Takamura H. Significance of Lymph Node Metastasis in the Treatment of Gastric Cancer and Current Challenges in Determining the Extent of Metastasis. Front Oncol. 2021;11:806162. [DOI:10.3389/fonc.2021.806162] [PMID] [PMCID]
  6. Zhang J, Zhou Y, Jiang K, Shen Z, Ye Y, Wang S. Evaluation of the seventh AJCC TNM staging system for gastric cancer: a meta-analysis of cohort studies. Tumour Biol. 2014;35(9):8525-32. [DOI:10.1007/s13277-014-1848-6] [PMID]
  7. Yamada T, Sugiyama H, Ochi D, Akutsu D, Suzuki H, Narasaka T, et al. Risk factors for submucosal and lymphovascular invasion in gastric cancer looking indicative for endoscopic submucosal dissection. Gastric Cancer. 2014;17(4):692-6. [DOI:10.1007/s10120-013-0323-1] [PMID]
  8. Liu L, Shi G-P. CD31: beyond a marker for endothelial cells. Oxford University Press; 2012. p. 3-5. [DOI:10.1093/cvr/cvs108] [PMID]
  9. Marelli-Berg FM, Clement M, Mauro C, Caligiuri G. An immunologist's guide to CD31 function in T-cells. J Cell Sci. 2013;126(Pt 11):2343-52. [DOI:10.1242/jcs.124099] [PMID]
  10. Bartley AN, Washington MK, Ventura CB, Ismaila N, Colasacco C, Benson III AB, et al. HER2 testing and clinical decision making in gastroesophageal adenocarcinoma: guideline from the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology. American J Clin Pathol. 2016;146(6):647-69. [DOI:10.1093/ajcp/aqw206] [PMID] [PMCID]
  11. Cheng WL, Wang CS, Huang YH, Tsai MM, Liang Y, Lin KH. Overexpression of CXCL1 and its receptor CXCR2 promote tumor invasion in gastric cancer. Ann Oncol. 2011;22(10):2267-76. [DOI:10.1093/annonc/mdq739] [PMID]
  12. Nazar E, Khatami F, Saffar H, Tavangar SM. The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis. Int J Hematol Oncol Stem Cell Res. 2019;13(2):72-82. [DOI:10.18502/ijhoscr.v13i2.692] [PMID] [PMCID]
  13. Hyung WJ, Lee JH, Choi SH, Min JS, Noh SH. Prognostic impact of lymphatic and/or blood vessel invasion in patients with node-negative advanced gastric cancer. Ann Surg Oncol. 2002;9(6):562-7. [DOI:10.1007/BF02573892] [PMID]
  14. Yazdi SAM, Nazar E, Shafiei S. The expression of SOX10 and its value for predicting tumor biological behaviors in patients suffering gastric adenocarcinoma, cross sectional study. Int J Surg Open. 2022:100558. [DOI:10.1016/j.ijso.2022.100558]
  15. Chen H, Guan R, Lei Y, Chen J, Ge Q, Zhang X, et al. Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis. BMC Cancer. 2015;15(1):1-7. [DOI:10.1186/s12885-015-1109-0] [PMID] [PMCID]
  16. Zhang C-D, Ning F-L, Zeng X-T, Dai D-Q. Lymphovascular invasion as a predictor for lymph node metastasis and a prognostic factor in gastric cancer patients under 70 years of age: a retrospective analysis. Int J Surg. 2018;53:214-20. [DOI:10.1016/j.ijsu.2018.03.073] [PMID]
  17. Yonemura Y, Endou Y, Tabachi K, Kawamura T, Yun HY, Kameya T, et al. Evaluation of lymphatic invasion in primary gastric cancer by a new monoclonal antibody, D2-40. Hum Pathol. 2006;37(9):1193-9. [DOI:10.1016/j.humpath.2006.04.014] [PMID]
  18. Mohamed SY, Mohammed HL, Ibrahim HM, Mohamed EM, Salah M. Role of VEGF, CD105, and CD31 in the Prognosis of Colorectal Cancer Cases. J Gastrointest Cancer. 2019;50(1):23-34. [DOI:10.1007/s12029-017-0014-y] [PMID]
  19. Sun H, Wu J. Expression and Significance of E-Cadherin and CD31 in Colorectal Cancer. 2018. [DOI:10.12677/JPS.2018.64004]
  20. Du CY, Chen JG, Zhou Y, Zhao GF, Fu H, Zhou XK, et al. Impact of lymphatic and/or blood vessel invasion in stage II gastric cancer. World J Gastroenterol. 2012;18(27):3610-6. [DOI:10.3748/wjg.v18.i27.3610] [PMID] [PMCID]
  21. Fujikawa H, Koumori K, Watanabe H, Kano K, Shimoda Y, Aoyama T, et al. The Clinical Significance of Lymphovascular Invasion in Gastric Cancer. In Vivo. 2020;34(3):1533-9. [DOI:10.21873/invivo.11942] [PMID] [PMCID]
  22. Dicken BJ, Graham K, Hamilton SM, Andrews S, Lai R, Listgarten J, et al. Lymphovascular invasion is associated with poor survival in gastric cancer: an application of gene-expression and tissue array techniques. Ann Surg. 2006;243(1):64. [DOI:10.1097/01.sla.0000194087.96582.3e] [PMID] [PMCID]
  23. Scartozzi M, Galizia E, Verdecchia L, Berardi R, Graziano F, Catalano V, et al. Lymphatic, blood vessel and perineural invasion identifies early-stage high-risk radically resected gastric cancer patients. Br J Cancer. 2006;95(4):445-9. [DOI:10.1038/sj.bjc.6603286] [PMID] [PMCID]
  24. Pak KH, Jo A, Choi HJ, Choi Y, Kim H, Cheong JH. The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis. BMC Cancer. 2015;15(1):498. [DOI:10.1186/s12885-015-1501-9] [PMID] [PMCID]
  25. Mei D, Zhao B, Zhang J, Luo R, Lu H, Xu H, et al. Impact of Lymphovascular Invasion on Survival Outcome in Patients With Gastric Cancer: A Retrospective Cohort Study. Am J Clin Pathol. 2020;153(6):833-41. [DOI:10.1093/ajcp/aqaa021] [PMID]
  26. Araki I, Hosoda K, Yamashita K, Katada N, Sakuramoto S, Moriya H, et al. Prognostic impact of venous invasion in stage IB node-negative gastric cancer. Gastric Cancer. 2015;18(2):297-305. [DOI:10.1007/s10120-014-0362-2] [PMID]
  27. Lee JH, Kim MG, Jung MS, Kwon SJ. Prognostic significance of lymphovascular invasion in node-negative gastric cancer. World J Surg. 2015;39(3):732-9. [DOI:10.1007/s00268-014-2846-y] [PMID]
  28. Da W, Zhang J, Zhang R, Zhu J. Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1/VEGF-D signaling. Int J Immunopathol Pharmacol. 2019;33:2058738419861600. [DOI:10.1177/2058738419861600] [PMID] [PMCID]
  29. Tang D, Gao J, Wang S, Ye N, Chong Y, Huang Y, et al. Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expression. Tumor Biol. 2016;37(2):1889-99. [DOI:10.1007/s13277-015-3942-9] [PMID]

30.Kakeji Y, Maehara Y, Sumiyoshi Y, Oda S, Emi Y. Angiogenesis as a target for gastric cancer. Surgery. 2002;131(1):S48-S54. [DOI:10.1067/msy.2002.119304] [PMID]

Iranian Journal of Pathology
Volume 18, Issue 2
Spring 2023
Pages 140-146

  • Receive Date 27 September 2022
  • Revise Date 10 January 2023
  • Accept Date 12 January 2023

Home

Guide for Authors

Submit Manuscript

Contact Us