Iranian Journal of Pathology

A Rare Case of Cardiac Metastasis from Colon Cancer

Document Type : Case Reports

Authors

Zahra Modabber 1
Roghayeh Pourkia 2
Hamidreza Vafaey 2
Ali Alizadeh 2
Mohammad Ranaei 3

1 Student Committee Research, Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran

2 Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran

3 Cellular and Molecular Biology Research Center, Health Research Institute, Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran

https://doi.org/10.30699/ijp.2022.551822.2874
Abstract
It is very rare for colorectal neoplasms to metastasize to the heart in the worldwide medical literature; only a single case of well-documented colorectal cancer metastasis to the left atrium was found. The case of a 66-year-old man is explained in this paper, who was suffering from metastatic adenocarcinoma of the colon that included the left atrium. In transthoracic and transesophageal echocardiography, a large multilobulated mass was present in the left atrium. An accidental pulmonary mass was also seen in a lung spiral CT scan. The cardiac mass was taken out, and a biopsy was obtained from the pulmonary mass. Adenocarcinoma was seen in histological assessment. Immunohistochemical staining was carried out to examine the expression of cytokeratin 7, cytokeratin 20, and caudal-related homeobox transcription factor 2 (CDX2) to determine the origin of the adenocarcinoma. In addition, the expression of these proteins was linked to the attributes of the patient and tumor. Post-surgery transesophageal echocardiography showed normal left ventricle and right ventricle function with no evidence of left atrium mass. Therefore, we suggest that asymptomatic cancer patients with a history of colorectal cancer and who have developed cardiac symptoms should be immediately examined for potential cardiac metastasis.

Keywords

Cardiac metastasis
Colorectal neoplasms
Heart
Left atrium
Metastatic adenocarcinoma

Subjects

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Iranian Journal of Pathology
Volume 17, Issue 4
Autumn 2022
Pages 477-481

  • Receive Date 14 April 2022
  • Accept Date 26 July 2022

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