Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Breast Pathology
1. Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer

Armin Borhan; Zohreh Nozarian; Alireza Abdollahi; Reza Shahsiah; Hadiseh Mohammadpour; Arash Borhan

Volume 16, Issue 1 , Winter 2021, , Pages 27-32

http://dx.doi.org/10.30699/ijp.2020.121532.2322

Abstract
  Background & Objective: Nowadays, actin-binding proteins such as Villin and Gelsolin have been considered to be associated with aggressive tumors. This study mainly aims to determine the relationship between Gelsolin and Villin genes expression and metastasis of axillary lymph nodes in patients with ...  Read More

Molecular Pathology
2. Variants of Genes Involved in Metabolism of Folate among Patients with Breast Cancer: Association of TYMS 3R Allele with Susceptibility to Breast Cancer and Metastasis

Zohreh Rahimi; Maryam Bozorgi Zarini Bozorgi Zarini; Ziba Rahimi; Ebrahim Shakiba; Asad Vaisi-Raygani; Mohammad Taher Moradi; Kheirolah Yari

Volume 16, Issue 1 , Winter 2021, , Pages 62-68

http://dx.doi.org/10.30699/ijp.2020.117676.2283

Abstract
  Background & Objective: Breast cancer (BC) is known to be the most prevalent cancer among women. One-carbon metabolism (OCM) disturbance might play an important role in the etiology of BC. The present study aimed to investigate the thymidylate synthase (TYMS), 5-methyltetrahydrofolate-homocysteine ...  Read More

Gynecologic Pathology
3. Predicting Effects of Clinicopathological Variables on Her2 Gene Amplification by Chromogenic in situ Hybridization (CISH) in IHC Her2 (2+) Breast Cancer Patients; A Study from Iran

Mohammad Hashemi-Bahremani; Abdolali Ebrahimi; Mohaddese Fallahi

Volume 15, Issue 3 , Summer 2020, , Pages 217-224

http://dx.doi.org/10.30699/ijp.2020.110293.2172

Abstract
  Background & Objective: The her2 amplification plays an important role in breast cancer management. Therefore, there is a need for using supplementary molecular methods in IHC equivocal cases. Present study has been conducted to determine the effects of clinicopathological variables on her2 gene ...  Read More

Breast Pathology
4. The Difference of Expression of 18 Genes in Axillary Invasion and Vascular Invasion Compared to Control Samples in Breast Cancer

Alireza Abdollahi; Sepideh Jahanian; Nima Hemmati; Hadiseh Mohammadpour

Volume 14, Issue 3 , Summer 2019, , Pages 223-231

http://dx.doi.org/10.30699/ijp.2019.92094.1894

Abstract
  Background & Objective: Recent studies from gene profiling have revealed some genes that are overexpressed in the epithelial-mesenchymal transition (EMT) process and are responsible for its initiation and activation resulting in tumor progression and metastasis. The present study aimed to assess ...  Read More

Breast Pathology
5. Vascular Mimicry Expression in Invasive Ductal Carcinoma; A New Technique for Prospect of Aggressiveness

Amir Hosein Jafarian; Melika Kooshkiforooshani; Abdolshakor Rasoliostadi; Nema Mohamadian Roshan

Volume 14, Issue 3 , Summer 2019, , Pages 232-235

http://dx.doi.org/10.30699/ijp.2019.94997.1939

Abstract
  Background & Objective: In vascular (vasculogenic) mimicry (VM), tumoral cells mimic the endothelial cells and form the extracellular matrix-rich tubular networks. It has been proposed that VM is more extensive in aggressive tumors. This study was designed to investigate the rate of VM expression ...  Read More

6. Clinical Value of Serum S100A8/A9 and CA15-3 in the Diagnosis of Breast Cancer

Samaneh Khorrami; Masoumeh Tavakoli; Elahe Safari

Volume 14, Issue 2 , Spring 2019, , Pages 104-112

http://dx.doi.org/10.30699/ijp.14.2.104

Abstract
  Background and Objective: S100A8/A9 is a heterodimer calcium-binding protein which is involved in tumor cell proliferation, adhesion and invasion, and is proposed as a biomarker for better diagnosis and prognosis in many cancers. The aim of this study was to evaluate the simultaneous serum-based level ...  Read More

Biology & Genetic
7. Relationship Between PIK3CA Amplification and P110α and CD34 Tissue Expression as Angiogenesis Markers in Iranian Women with Sporadic Breast Cancer

Shadi Hosseini; Farkhondeh Behjati; Maryam Rahimi; Nazanin Taheri; Hamid Reza Khorram Khorshid; Fatemehte Aghakhani Moghaddam; Saghar Ghasemi Frouzabadi; Masoud Karimlou; Fereidoon Sirati; Elahe Keyhani

Volume 13, Issue 4 , Autumn 2018, , Pages 447-453

Abstract
  Background and Objective: The PI3K/AKT/mTOR pathway is known to play an important role in regulating angiogenesis both in normal and breast cancer (BC) tissues. PIK3CA amplification was reported in various malignancies, including approximately 10% of BC cases. The aim of this study was to identify the ...  Read More

8. Tissue Expression of Prohibition-I and Its Relationship With Prognostic Factors in Breast Cancer

Hossein Javid; Isaac Hashemy; Soudabeh Shahid sales; Nema Mohammadian Roshan; Tayyebeh Kianoosh; Farnaz Zahedi Avval

Volume 13, Issue 2 , Spring 2018, , Pages 237-244

http://dx.doi.org/10.30699/ijp.13.2.237

Abstract
  Background & objective: Globally, breast cancer is the most common malignancy among females. Prohibition (PHB)-I, a homologous protein, was initially introduced as a suppressor gene for amplification process. Further, the protein has a key role in the cell cycle and is capable of inhibiting ...  Read More

Hematopathology
9. Prognostic Significance of Reduction in Ki67 Index After Neoadjuvant Chemotherapy in Patients With Breast Cancer in Kerman Between 2009 And 2014

Vahid Moazed; Elham Jafari; Behjat Kalantari khandani; Ali Nemati; seyedamir benrazavi

Volume 13, Issue 1 , Winter 2018, , Pages 71-77

http://dx.doi.org/10.30699/ijp.13.1.71

Abstract
  Background and objective:Breast cancer is the most common malignancy among women. The Neoadjuvant chemotherapy is the treatment of choice for non-operable tumors. The Ki67 is a proliferation marker that can be used to predict the therapeutic response to chemotherapy and the patients' prognosis. Methods: ...  Read More

10. High Expression of Sphingosine Kinase 1 in Estrogen and Progesterone Receptors-Negative Breast Cancer

Azadeh Sadat Nazouri; omolbanin asadpour; Shahriar Dabiri; Bahram Pourseyedi; Mohamad reza Lashkarizadeh; Hamid Zeinalyneghad

Volume 12, Issue 3 , Summer 2017, , Pages 218-224

http://dx.doi.org/10.30699/ijp.2017.25049

Abstract
  Background & objective: Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell ...  Read More

11. The Core Needle and Surgical Biopsy Concordance to Detect Estrogen, Progesterone, and Her-2 Receptors in Breast Cancer: A Comparative Study

Fereshteh Ensani; Ramesh Omranipour; Isa Jahanzad; Azadeh Jafari; Shima Nafarzadeh; Pouyan Aminishakib

Volume 12, Issue 3 , Summer 2017, , Pages 202-208

http://dx.doi.org/10.30699/ijp.2017.25042

Abstract
  Background &Objectives: Evaluation of estrogen receptor (ER), progesterone receptor (PR), and (human epidermal growth factor receptor-2) Her-2 on core needle biopsies (CNBs) is increasingly in use to diagnosis early breast cancer, but its concordance with surgical excision (SE) is not well documented. ...  Read More

Biochemistry
12. Effect of Silibinin on Maspin and ERα Gene Expression in MCF-7 Human Breast Cancer Cell Line

Maryam Karimi; Hossein Babaahmadi-Rezaei; Ghorban Mohammadzadeh; Mohammad-Ali Ghaffari

Volume 12, Issue 2 , Spring 2017, , Pages 135-143

http://dx.doi.org/10.30699/ijp.2017.24871

Abstract
  Background and objective: According to reports, a serine protease inhibitor (Maspin) suppresses metastasis, invasion and angiogenesis in breast and prostate cancers. Silibinin is a natural polyphenolic flavonoid with anti-cancer activity. We assessed the effects of silibinin on cell viability, maspin ...  Read More

Hematopathology
13. Chromogenic in situ Hybridization Compared with Real Time Quantitative Polymerase Chain Reaction to Evaluate HER2/neu Status in Breast Cancer

Hossein Ayatollahi; Azar Fani; Ehsan Ghayoor Karimiani; Fateme Homaee; Arezoo Shajiei; Maryam Sheikh; Sepideh Shakeri; Seyyede Fatemeh Shams

Volume 12, Issue 2 , Spring 2017, , Pages 128-134

http://dx.doi.org/10.30699/ijp.2017.24870

Abstract
  Background and objective: The assessment of human epidermal growth factor receptor 2 (HER2) status has become of great importance in the diagnosis of breast cancer. The aim of this study was to investigate the diagnostic value of quantitative Polymerase Chain Reaction (qPCR) and Chromogenic In Situ Hybridization ...  Read More

Hematopathology
14. Fluorescent in Situ Hybridization and Real-Time Quantitative Polymerase Chain Reaction to Evaluate HER-2/neu Status in Breast Cancer

Fatemeh Homaei Shandiz; Azar Fani; Sepideh Shakeri; Maryam Sheikhi; Abouzar Ramezani Farkhani; Arezoo Shajiei; Hossein Ayatollahi

Volume 12, Issue 1 , Winter 2017, , Pages 67-73

http://dx.doi.org/10.30699/ijp.2017.24228

Abstract
  Background:Breast cancer remains the most common and second lethal cancer in females. HER-2/neu is one of the most important amplified oncogene in breast cancer. The amplification of HER-2 is correlated with decreased survival, metastasis, and early recurrence.  The amplification of HER-2/neu gene ...  Read More

Hematopathology
15. Jaw Pain as a First Presentation in the Diagnosis of Breast Cancer

Payam Azadeh; Nasser Rakhashni; Ali Yaghobi Joybari; Pegah Gorji Bayani; Samaneh Sarbaz; Maryam Farasatinasab

Volume 11, Issue 5 , Autumn 2016, , Pages 439-442

Abstract
  The oral cavity is uncommon site for metastatic disease usually discovered secondary to malignancy. We encountered with a rare case in which metastasis to mandibular bone was the first clinical sign in the diagnosis of breast cancer without any radiographic findings. A 49-yr-old premenopausal woman, ...  Read More

Biology & Genetic
16. Maspin Gene Expression in Invasive Ductal Carcinoma of Breast

Shahriar Dabiri; Mohammadmehdi Moeini aghtaei; Jahanbano Shahryari; Manzume Shamis meymandi; Sahar Amirpour-Rostami; Reza Foutohi-Ardekani

Volume 11, Issue 2 , Spring 2016, , Pages 104-111

Abstract
  Background: The breast cancer is the most prevalent cancer among women, on the other hand absence of myoepithelial cells play a pivotal role in pathogenesis of this cancer. Thus we aimed to investigate the possible abilities of the molecular assay technique to find a relationship between mammary serine ...  Read More

17. Frequency of Human Papillomavirus Genotypes 6, 11, 16, 18 And 31 in Paraffin-Embedded Tissue Samples of Invasive Breast Carcinoma, North-East of Iran

Masoumeh Salehpour; Naser Tayyebi Meibodi; Roghayeh Teimourpour; Adel Ghorani-Azam; Samaneh Sepahi; Sina Rostami; Zahra Meshkat

Volume 10, Issue 3 , Summer 2015, , Pages 192-198

http://dx.doi.org/10.7508/ijp.2015.03.003

Abstract
  Background &Objective: Breast cancer is the most common female malignancy. Detection of DNA of human papillomaviruses (HPVs) in breast carcinomas suggests that the virus may play a role in the pathogenesis of this disease. The aim of this study was to evaluate the frequency of HPVs genotypes 6, 11, ...  Read More

18. Methylation Analysis of 5’UTR Promoter Region of DBC2 as a Biomarker in the Peripheral Bloods of Some Iranian Women with Sporadic Breast Cancer

Fahimeh Mousavi; Mehrdad Noruzinia; Elahe Keyhani; Feridoon Seirati; Samira Rezaei; Forough Mojtahedi; Farkhondeh Behjati

Volume 9, Issue 2 , Spring 2014, , Pages 117-123

Abstract
  Background and Objective: The DBC2 (deleted in breast cancer 2) or RhoBTB2 (Located on 8p21) is a tumor suppressor gene associated with tumorigenesis. Mutational studies of DBC2 at its promoter region in breast cancer revealed an important role for epigenetic changes contributing to its low expression. ...  Read More

19. Expression of Anaplastic Lymphoma Kinase Protein in Human Breast Cancer

Ali Zare Mehrjardi; Amineh Vaghefi

Volume 8, Issue 1 , Winter 2013, , Pages 27-35

Abstract
  Background & Objectives: Anaplastic lymphoma Kinase (ALK) is a receptor tyrosine kinase involved in the genesis of several human cancers. ALK was initially identified because of its involvement in anaplastic large cell lymphoma (ALCL). ALK is believed to foster tumorigenesis following activation ...  Read More

20. Male Breast Carcinoma: An Immunohistochemical Study Of 50 Cases From Iran

Fatemeh Mahjoub; Farrokh Tirgari; Afshin Abdi Rad; Mahmoud Mohammadi; Nargess Tabarzan; Omid Emadian

Volume 3, Issue 2 , Winter 2008, , Pages 95-99

Abstract
  Background and Objective: Male breast carcinoma (MBC) is an unusual form of neoplasia, representing 0.7 to 1 percent of all breast cancer cases. Usually, the carcinoma affects patients after the sixth decade. The aim of this study was to evaluate the status of estrogen and progesterone receptors (ER ...  Read More

21. Evaluation Of The Androgen Receptor Status In Invasive Ductal Carcinoma Of Breast

Nasrin Shayanfar; Behrang Kazeminejad

Volume 3, Issue 1 , Winter 2008, , Pages 30-34

Abstract
    Background and Objective: Determination of hormone receptor status in the management of breast cancer is well-established. The aim of this study was to evaluate the frequency of androgen receptor (AR) expression in invasive ductal carcinoma of breast. Materials and Methods: For this purpose, ...  Read More

22. Is “Basal-like” Carcinoma of the Breast a Distinct Clinicopathologic Entity? A Critical Review with Cautionary Notes

Farid Moinfar

Volume 2, Issue 4 , Summer 2007, , Pages 127-143

Abstract
  This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma recently known as “basal-like” carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, ...  Read More

23. Chemotherapy-induced Ovarian Failure And The Related Indices In Breast Cancer Patients

Robab Anbiaee; Payam Azadeh; Abdollah Fazlalizadeh

Volume 1, Issue 3 , Spring 2006, , Pages 105-108

Abstract
  Background and Objective: It is well known that menstrual period and ovarian function are affected by chemotherapy. Although breast cancer is the most common cause of chemotherapy in women and ovarian hormones have very important direct and indirect effects on overall survival, disease-free survival, ...  Read More