Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Number of Volumes 16
Number of Issues 63
Number of Articles 800
Number of Contributors 2,509
View Per Article 1519.16
PDF Download Per Article 880.45
Number of Submissions 1,636
Number of Indexing Databases 48
Number of Reviewers 568

Iranian Journal of Pathology (Iran J Pathol)

Quarterly Journal of Anatomical and Clinical Pathology

The IRANIAN JOURNAL OF PATHOLOGY (IJP),  is an international journal and publishes original research papers, reviews, case reports, short communications, and letters to the editor with priority for high-quality original papers on mechanisms of disease and clinical trials. We accept manuscripts that report important findings on disease pathogenesis and basic biological mechanisms that relate to disease without preferences for a  specific method of analysis. High priority is given to studies on human diseases and relevant experimental models that use cellular, molecular, biochemical & immunological approaches in conjunction with morphology, and to manuscripts that report new diagnostic methods or analytical systems and their application in studies of disease pathogenesis and diagnosis.   

 

  • Bone and Soft Tissue Pathology,
  • Dermatopathology,
  • Biochemistry,
  • Biology & Genetic,
  • Infectious Diseases,
  • Microbiology,
  • GI pathology & Hepatopathology,
  • Endocrine Pathology,
  • ENT & Ophthalmic Pathology,
  • Gynecologic & Breast Pathology,
  • Molecular Pathology,
  • Nephropathology,
  • Neuropathology,
  • Neuroscience and Anatomy,
  • Oncology & Hematology,
  • Oral Pathology,
  • Pediatric Pathology,
  • Surgical Pathology,
  • Diagnostic Pathology,
  • Uropathology

 

             

 

Original Research Breast Pathology
1. D2-40 A Helpful Marker in Assessment of Lymphatic Vessel Invasion in Carcinoma of BreastTumor characteristic Number of cases (percentage %)

Zeinab Vosough; Shima Golbini; Majid Sharbatdaran; Akramossadat Hosseini

Volume 16, Issue 2 , Spring 2021, Pages 96-102

http://dx.doi.org/10.30699/ijp.2020.114511.2245

Abstract
  Background & Objective: Breast cancer is the most common malignancy in Iranian women and worldwide. Lymphatic vessel invasion (LVI) was found to be an independent prognostic factor in many carcinomas, including invasive carcinoma of the breast. The aim of this study was to compare the hematoxylin ...  Read More

Original Research Dermatopathology
2. CD137: A Member of the TNFR Family - in Psoriasis Skin Lesions in Comparison with Normal Skin Specimens

Parvin Rajabi; Syed Mehdi Eftekhari; Azadeh Kadkhodaii; Amirhosein Kefayat

Volume 16, Issue 2 , Spring 2021, Pages 103-108

http://dx.doi.org/10.30699/ijp.2020.118767.2290

Abstract
  Background and Objective: CD137 is a member of the TNF-Receptor family. TNF-alpha antagonists have therapeutic effect in active psoriasis. In this study, the relative frequency of CD137 expression was investigated in the inflammatory cells of psoriasis lesions for the first time. Methods: The specimens ...  Read More

Original Research Gynecologic Pathology
3. Improvement of Targeted Chemotherapy of HER2-positive Ovarian Malignant Cell Line by ZHER2-Idarubicin Conjugate: An in vitro Study

Lila Siavoshinia; Mostafa Jamalan; Majid Zeinali; Aminollah Pourshohod; Mahdie Koushki; Bahman Moradipoodeh; Ghorban Mohammadzadeh

Volume 16, Issue 2 , Spring 2021, Pages 109-118

http://dx.doi.org/10.30699/ijp.2020.120392.2310

Abstract
  Background & objectives: Overexpression of human epidermal growth factor receptor 2 (HER2) causes cell transformation and development of various types of malignancies. Idarubicin is an effective anti-neoplastic drug but specific delivery of it to the targeted cells is still a great challenge. Affibody ...  Read More

Original Research Uropathology
4. Survey of Mast Cell Density in Transitional Cell Carcinoma

Hedieh Moradi Tabriz; Maedeh Obohat; Farzan Vahedifard; Arezoo Eftekharjavadi

Volume 16, Issue 2 , Spring 2021, Pages 119-127

http://dx.doi.org/10.30699/ijp.2020.123562.2345

Abstract
  Background & Objective: Transitional cell carcinoma (TCC) is the world's seventh most common tumor and forms more than 90% of urinary bladder tumors. Invasive tumors have had a poor prognosis, even with surgical treatment and chemotherapy. Some studies have found that an increase of mast cells in ...  Read More

Original Research Neuropathology
5. Expression and Prognostic Significance of Cancer/Testis Antigens, MAGE-E1, GAGE, and SOX-6, in Glioblastoma: An Immunohistochemistry Evaluation

Seyed Abbas Tabatabaei Yazdi; Masoomeh Safaei; Mehran Gholamin; Alireza Abdollahi; Fatemeh Nili; Mehdi Jabbari Nooghabi; Kazem Anvari; Majid Mojarrad

Volume 16, Issue 2 , Spring 2021, Pages 128-136

http://dx.doi.org/10.30699/ijp.2020.125038.2368

Abstract
  Background & Objectives: Glioblastoma is the most common primary malignancy of the brain, the prognosis of which is poor. Immunotherapy with cancer/testis (CT) antigens is a novel therapeutic approach for glioblastoma. This study aimed to investigate the expression rate of MAGE-E1, GAGE, and SOX-6 ...  Read More

Original Research Microbiology
6. Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission

Saeed Mirsadraee; Mihan Pourabdollah Toutkaboni; Mehrdad Bakhshayeshkaram; Mitra sadat Rezaei; Elham Askari; Sara Haseli; Nazanin Sadraee

Volume 16, Issue 2 , Spring 2021, Pages 137-143

http://dx.doi.org/10.30699/ijp.2020.128909.2415

Abstract
  Background & Objective: Diagnosis of coronavirus disease 2019 (COVID-19) can be challenging, especially when the real­time quantitative reverse transcription polymerase chain reaction (RT-PCR) is not available or it is negative. In this study, we evaluated imaging and laboratory findings in a ...  Read More

Original Research Biochemistry
7. Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease

Ahmad Raesi; Ebrahim Saedi Dezaki; Hamideh Moosapour; Farzaneh Saeidifard; Zahra Habibi; Fereidoun Rahmani; Soleiman Kheiri; Elham Taheri

Volume 16, Issue 2 , Spring 2021, Pages 144-153

http://dx.doi.org/10.30699/ijp.2020.130491.2442

Abstract
  Background & Objective:  Previous studies have addressed the electrolyte abnormalitiessuch as hypocalcemiain COVID-19 patients. We aimed to compare the laboratory findings especially the electrolyte levels amongCOVID-19 patients and healthy controls and evaluate their prognostic values. Materials ...  Read More

Original Research Uropathology
8. Survivin and Her2 Expressions in Different Grades of Urothelial Neoplasms of Urinary Bladder

Hedieh Moradi Tabriz; Elham Nazar; Seyed Ali Ahmadi; Esmaeil Azimi; Fazeleh Majidi

Volume 16, Issue 2 , Spring 2021, Pages 154-161

http://dx.doi.org/10.30699/ijp.2020.130859.2447

Abstract
  Background and Objective: Urothelial neoplasm (UN) of bladder is a potentially lethal malignancy, particularly in locally advanced or metastatic cases. Development of molecular markers such as HER2 and Survivin may provide useful information on diagnosis and prognosis in UN of bladder. Materials and ...  Read More

Original Research Pulmonary Pathology
9. The Diagnostic and Prognostic Roles of Combined Expression of Novel Biomarkers in Lung Adenocarcinoma (LUAD) and Lung Squamous Cell Carcinoma (LUSC); An Immunohistochemical Study

Mohamed Alabiad; Ola Harb; Mohamed Abozaid; Ahmed Embaby; Doaa Mandour; Rehab Hemeda; Amany Shalaby

Volume 16, Issue 2 , Spring 2021, Pages 162-173

http://dx.doi.org/10.30699/ijp.2020.130944.2452

Abstract
  Background and Objective: Diagnosis and discrimination of lung adenocarcinoma (LUAD) from lung squamous cell carcinoma (LUSC) is critical to select the appropriate treatment regimen as recently targeted therapies require accurate subtyping of NSCLCs. There are currently several biomarkers that could ...  Read More

Original Research Biochemistry
10. Protective Effect of Combined Long Time Administration of Selenium and Vitamin C on Liver and Kidney Toxicity of Cadmium in Rats

Mohammad Mahdi Zamani; Seyedeh Hamideh Mortazavi; Maryam Monajemzade; Vahhab Piranfar; Zahra Aalidaeijavadi; Azam Bakhtiarian

Volume 16, Issue 2 , Spring 2021, Pages 174-180

http://dx.doi.org/10.30699/ijp.2020.135777.2489

Abstract
  Background and Objective: Increased industrial activities leads to prolonged human exposure to industrial pollutant such as cadmium (Cd). ‍Chronic exposure to Cd in Mammals and also human being, can cause damages to various organs and particularly kidneys and liver. The goal of this study was to ...  Read More

Original Research
11. Expression of P63, P16 and CK17 in Atypical Squamous Metaplasia and Cervical Intraepithelial Neoplasia

Maryam Iranpour; Shahriar Dabiri; Mitra Rezazade; Fatemeh Bagheri

Volume 16, Issue 2 , Spring 2021, Pages 181-189

http://dx.doi.org/10.30699/ijp.2021.104280.2095

Abstract
  Background & Objective: Cervical intraepithelial neoplasia (CIN) is a dysmaturation process in squamous cells in epithelial layer, which highly increases the risk of developing cervical cancer. The aim of this study was to compare the expression of three biomarkers, p16, p63, and CK17 in patients ...  Read More

Original Research Hematopathology
12. JAK2, CALR, and MPL Mutation Profiles in BCR-ABL Negative Myeloproliferative Neoplasms, a Referral Center Experience in the Middle East

Moeinadin Safavi; Ahmad Monabati; Akbar Safaie; Maryam Mirtalebi; Masoumeh Faghih

Volume 16, Issue 2 , Spring 2021, Pages 190-194

http://dx.doi.org/10.30699/ijp.2021.136458.2495

Abstract
  Background: This study was conducted to evaluate the frequency of JAK2, CALR and MPL mutations in with BCR-ABL myeloproliferative neoplasms and their association with demographic data and hematologic parameters in a referral center, in the Middle East. Methods: Seventy-one patients with BCR-ABL negative ...  Read More

Original Research Head and Neck Pathology
13. Reduced Expression of Galectin-8 May Contribute in Carcinogenic Pathway of Head and Neck Squamous Cell Carcinoma

Maryam Ghasemi; Laleh Vahedi Larijani; Jamshid azdani-Charati; Elham Kamali Hakim

Volume 16, Issue 2 , Spring 2021, Pages 195-204

http://dx.doi.org/10.30699/ijp.2021.121140.2318

Abstract
  Background & Objectives: Galectin-8 has relationships with cell growth and metastasis of some cancers. Due to controversy in the clinical significance of this protein in the cancer process, we investigated its roles in the development of head and neck squamous cell carcinoma. Methods: This study ...  Read More

Original Research GI, Liver & Pancreas Pathology
14. Candidate Molecular Biomarkers for the Non- Invasive Detection of Colorectal Cancer using Gene Expression Profiling

Mohammad Shafiei; Mahdi Alemrajabi; Ali Najafi; Amirhomayoon Keihan; Masoudreza Sohrabi

Volume 16, Issue 2 , Spring 2021, Pages 203-212

http://dx.doi.org/10.30699/ijp.2021.132385.2475

Abstract
  Background and Objective: Colorectal Cancer (CRC) is the third most common cancer after prostate (breast in women) and lung cancer; it is also the third cause of cancer deaths reported in both men and women in 2020. Currently, the most commonly used diagnostic tools for CRC are colonoscopy, serological ...  Read More

Original Research Nephropathology
15. Polyomavirus Associated Nephropathy: Frequency and Graft Survival Analysis in Northeast of Iran

Shirin Taraz Jamshidi; Khadijeh Sajjadian; Maryam Emadzadeh; Malihe Saber Afsharian; Mahmoud Reza Kalantari; Anita Alenabi; Abbas Ali Zeraati; Ali Emadzadeh

Volume 16, Issue 2 , Spring 2021, Pages 215-221

http://dx.doi.org/10.30699/ijp.2021.128489.2403

Abstract
  Background & Objectives: Polyomavirus-associated nephropathy (PVAN), mainly caused by the BK virus, is one of the most important infectious complications of kidney transplantation. The leading histopathologic characteristics of PVAN is viral cytopathic effects, such as nucleomegaly with smudged or ...  Read More

Case Reports Neuropathology
16. Intra-cranial Chondroma: A Case Report and Problematic Diagnosis

Arezoo Eftekhar Javadi; Elham Nazar; Hedieh Moradi Tabriz

Volume 16, Issue 2 , Spring 2021, Pages 222-226

http://dx.doi.org/10.30699/ijp.2021.132377.2472

Abstract
  Introduction: Chondroma is a benign cartilaginous tumor. It is found very rarely in the head and neck. Case presentation: This report describes a 25-year-old woman who presented with generalized headache from 4 months ago. The patient underwent excisional surgery. The histological examinations revealed ...  Read More

Case Reports Gynecologic Pathology
17. Mesonephric Adenocarcinoma of Uterine Cervix; A Case Report and Review of the Literature

Fatemeh Nili; Samaneh Salarvand; Hana Saffar; Bita Kalaghchi; Reza Ghalehtaki

Volume 16, Issue 2 , Spring 2021, Pages 227-231

http://dx.doi.org/10.30699/ijp.2020.125459.2375

Abstract
  Mesonephric adenocarcinoma of the uterine cervix, an extremely rare tumor of the female genital tract, derives from the remnants of embryonic mesonephric ducts and its prognosis, diagnosis and treatment is rather challenging. We report a case of a 46-year-old woman with history of abnormal uterine bleeding ...  Read More

Case Reports Uropathology
18. Burned-out Post Pubertal Teratoma Presenting as a Liver Metastases in a 34-Year-Old Male

Fereshteh Ameli; Pooneh Panahi; Vahid Soleimani

Volume 16, Issue 2 , Spring 2021, Pages 232-236

http://dx.doi.org/10.30699/ijp.2020.128407.2402

Abstract
  Germ cell teratomas belong to nonseminomatous germ cell tumors and account for 95% of malignant testicular tumors. Regarding the current World Health Organization (WHO) criteria, testicular teratomas are divided into prepubertal and postpubertal subtypes based on patients’ age. The term “burned-out ...  Read More

Case Reports Hematopathology
19. Interdigitating Dendritic Cell Tumor of Submandibular Lymph Node: Case Report and Literature Review

Soroush Felezi; Anahita Nosrati; Mohammad Eslami Jouybari; Javane Jafarshad

Volume 16, Issue 2 , Spring 2021, Pages 237-242

http://dx.doi.org/10.30699/ijp.2020.120698.2411

Abstract
  Dendritic cells (DCs) are key arms of immune system, which act in antigen presenting processes, and are considered as a bridge between innate and adaptive immune responses. DCs are found in both lymphoid and non-lymphoid organs. They are called interdigitating dendritic cells (IDCs) in secondary lymphoid ...  Read More

Transfusion
1. The Novel Coronavirus SARS-CoV-2 Vulnerability Association with ABO/Rh Blood Types

Alireza Abdollahi; Maedeh Mahmoudi-aliabadi; Vahid Mehrtash; Bita Jafarzadeh; Mohammadreza Salehi

Volume 15, Issue 3 , Summer 2020, , Pages 156-160

http://dx.doi.org/10.30699/ijp.2020.125135.2367

Abstract
  Background & Objective: Coronavirus disease 2019 (COVID-19) is the most recent emerging viral disease. Defining the epidemiological aspects and factors influencing the susceptibility of the patients to COVID-19 has been an ongoing struggle. In the present study, we have investigated the connection ...  Read More

Microbiology
2. Serology Testing for SARS-CoV-2: Benefits and Challenges

Mohammadreza Jalali Nadoushan; Soha Ahmadi; Paniz Jalali Nadoushan

Volume 15, Issue 3 , Summer 2020, , Pages 154-155

http://dx.doi.org/10.30699/ijp.2020.39841

Abstract
  As COVID-19 was declared as a pandemic by the World Health Organization (WHO) in March 2020, it is an emerging need to discuss different aspects of this pandemic. In any pandemic, valid and rapid laboratory diagnostic tests are critically important for early diagnosis, which will increase the rate of ...  Read More

Neuropathology
3. Histopathological Spectrum of Meningiomas with Emphasis on Prognostic Role of Ki67 Labelling Index

Girish Solanke; Vidya Monappa; Ranjini Kudva

Volume 15, Issue 3 , Summer 2020, , Pages 197-204

http://dx.doi.org/10.30699/ijp.2020.107195.2119

Abstract
  Background & Objective: Meningiomas are the most frequently encountered primary non-glial tumors of the central nervous system (CNS). The Ki67 labelling index (Ki67LI) is a proliferation marker that may prove useful in determining the histological grade. This study aims at: 1) Studying the frequency, ...  Read More

Diagnostic Pathology
4. Necessity of Routine Repeat Testing of Critical Values in Various Working Shifts

Hiva Saffar; Alireza Abdollahi; Atefe Sadat Hosseini; Mojgan Torabi Farsani; Ghazal Hajinasrollah; Pegah Mohaghegh

Volume 15, Issue 3 , Summer 2020, , Pages 161-166

http://dx.doi.org/10.30699/ijp.2020.99403.1980

Abstract
  Background & Objective: Accurate and timely reporting of critical values is an important issue. There is some doubt whether repeat testing of critical values would offer any advantage over single testing or not. The aim of this study was evaluation of utility of routine repeat testing of critical ...  Read More

Oral Pathology
5. Detection of Apoptosis in Leukoplakia and Oral Squamous Cell Carcinoma using Methyl Green Pyronin and Hematoxylin and Eosin

Pooja Sharma; Anjali Narwal; Mala Kamboj

Volume 15, Issue 3 , Summer 2020, , Pages 189-196

http://dx.doi.org/10.30699/ijp.2020.107263.2115

Abstract
  Background & Objective: Cell population and turnover are controlled by a balance between cell proliferation and apoptosis. Detection of apoptosis in oral cancer contributes to its better prognosis and improved management. This study aimed to quantify apoptotic cells in leukoplakia and oral squamous ...  Read More

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