Document Type : Short Communication
Authors
1 Breast Diseases Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
2 Breast Diseases Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Department of Surgery, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Mostafa Khomeini Hospital, Shahed University, Tehran, Iran
4 Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Background & Objective: Antigen Ki-67 (histone-based nuclear protein) is a static marker of tumor cell proliferation and growth and is commonly measured to indicate the effect of treatment in breast cancer patients. This single-arm trial study aimed to evaluate the effect of short-term endocrine therapy (letrozole) on Ki-67 levels in menopausal women with early hormone-positive breast cancer who were referred to two university hospitals.
Methods: Patients with a pre-treatment Ki67 of 5% or less were excluded from the study. Participants (n=25) received oral letrozole (2.5 mg daily) seven days before surgery. Ki-67% on both the biopsy and the surgical specimens were measured and compared.
Results and Conclusion: The mean age of patients was 62±9.4 (48-83 years). Our result indicated that consumption of letrozole before surgery for hormone-positive breast cancer can significantly decrease the level of Ki-67 (23.24±9.74 vs. 16.92±9.55, P=0.001 by paired t-test), with no drug-related adverse events.
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Main Subjects
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