Volume 17 (2022)
Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Evaluation of FLT3-ITD Mutations and MDR1 Gene Expression in AML Patients

ehsan yazdandoust; mohammad hadidi sadeghian; seyyede fatemeh shams; Yasaman Saadatpour; payam siyadat; maryam sheikhi; Monavar Afzal Aghaee; Hossein Ayatollahi

Volume 17, Issue 4 , October 2022, , Pages 419-426


  Background & Objective: Acute myeloid leukemia (AML) is a hematopoietic malignancy caused by genetic abnormalities. These days, molecular and genetic factors are usually used as diagnostic and prognostic markers. FLT-3 is one of the most known diagnostic factors in AML. MDR1 gene belongs to the ATP ...  Read More

Severe Prekallikrein Deficiency Associated with Low Level of Factor XII: A Case Report

Massoumeh Shahbazi; Minoo Ahmadinejad; Shahnaz Fakhrzadegan

Volume 16, Issue 3 , July 2021, , Pages 332-336


  Hereditary deficiency of plasma prekallikrein (PPK) is a rare autosomal recessive disease. The affected patients are often asymptomatic and diagnosed incidentally during preoperative investigations or during hospitalization by isolated prolongation of activated partial thromboplastin time (aPTT). In ...  Read More

JAK2, CALR, and MPL Mutation Profiles in BCR-ABL Negative Myeloproliferative Neoplasms, a Referral Center Experience in the Middle East

Moeinadin Safavi; Ahmad Monabati; Akbar Safaie; Maryam Mirtalebi; Masoumeh Faghih

Volume 16, Issue 2 , April 2021, , Pages 190-194


  Background: This study was conducted to evaluate the frequency of JAK2, CALR and MPL mutations in with BCR-ABL myeloproliferative neoplasms and their association with demographic data and hematologic parameters in a referral center, in the Middle East. Methods: Seventy-one patients with BCR-ABL negative ...  Read More

Interdigitating Dendritic Cell Tumor of Submandibular Lymph Node: Case Report and Literature Review

Soroush Felezi; Anahita Nosrati; Mohammad Eslami Jouybari; Javane Jafarshad

Volume 16, Issue 2 , April 2021, , Pages 237-242


  Dendritic cells (DCs) are key arms of immune system, which act in antigen presenting processes, and are considered as a bridge between innate and adaptive immune responses. DCs are found in both lymphoid and non-lymphoid organs. They are called interdigitating dendritic cells (IDCs) in secondary lymphoid ...  Read More

The changes of Coagulation State in Patients Contracted with SARS-COV-19

Anahita Nosrati

Volume 15, Issue 4 , October 2020, , Pages 259-260


  Coronaviruses are considered to be one of the most significant human and animal pathogens. In late 2019, a new species of coronavirus was recognized as the cause of some pneumonia cases in Wuhan, China. The disease spread rapidly and made an epidemic in China and subsequently in almost all countries ...  Read More

Overexpression of MicroRNA-506 in Jurkat (acute T Cell Leukemia) Cell Line

Shaghayegh Rostami Yasuj; Narges Obeidi; Gholamreza Khamisipour; Zeynab Gharehdaghi; Zivar Zangeneh

Volume 15, Issue 4 , October 2020, , Pages 282-291


  Background & Objective:  Acute lymphoblastic leukemia (ALL) is a malignant disease that arises from various mutations in B or T-lymphoid progenitors. MicroRNAs (miRNAs) regulate gene expression by binding to the 3' untranslated region of protein-coding genes. Dysregulation of miRNA expression ...  Read More

The Association of FLT3-ITD Gene Mutation with Bone Marrow Blast Cell Count, CD34, Cyclin D1, Bcl-xL and hENT1 Expression in Acute Myeloid Leukemia Patients

Paulus Budiono Notopuro; Jusak Nugraha; Budi Utomo; Harianto Notopuro

Volume 15, Issue 4 , October 2020, , Pages 306-312


  Background & Objective:  FLT3-ITD has been recently used as a molecular prognostic marker for risk classification in acute myeloid leukemia (AML) therapy. In this study we aimed to investigate the association of FLT3-ITD gene mutation with bone marrow blast cell count, CD34 expression as ...  Read More

Matrix metalloproteinase-9 (MMP-9) Expression in Non-Small Cell Lung Carcinoma and Its Association with Clinicopathologic Factors

Amir Hossein Jafarian; Melika Kooshki forooshani; Hossein Reisi; Nema Mohamadian roshan

Volume 15, Issue 4 , October 2020, , Pages 326-333


  Background & Objective:  Matrix metalloproteinases-9 (MMP-9) is one of the most important enzymes to breakdown extracellular matrix which plays a major role in tumor invasion and metastasis. This study aimed to determine tumor MMP-9 expression in non-small-cell lung carcinoma (NSCLC) and ...  Read More

The Survival of Patients with t(15;17)(q22;q12) Positive Acute Promyelocytic Leukemia: A Study in North-East of Iran

Hossein Ayatollahi; Ali Bazi; Mohammad Hadi Sadeghian; Ali Fani; Payam Siyadat; Maryam Sheikhi; Omolbanin Sargazi-aval

Volume 15, Issue 3 , July 2020, , Pages 175-181


  Background & Objective: Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12) is a relatively common subtype of acute myeloid leukemia (AML).  Here, our objective was to ascertain the survival of patients with this leukemia in north-east of Iran. Methods:  Survival rates of ...  Read More

Cytogenetics and Revised International Staging System (R-ISS): Risk Stratification in Multiple myeloma - A Retrospective Study in Indian Population

Chethana Babu Udupa; KARTHIK UDUPA; Ananth Pai; Prathika Sherigar

Volume 15, Issue 3 , July 2020, , Pages 182-188


  Background & Objective: Cytogenetic abnormalities in Multiple myeloma (MM) has emerged as the most important factor that determine the prognosis and survival. Fluorescence in situ hybridization (FISH) can detect a greater number of cytogenetic abnormalities as compared to conventional karyotyping ...  Read More

Characterization of Immunophenotypic Aberrancies in Adult and Childhood Acute Lymphoblastic Leukemia: Lessons from Regional Variation

Mitra Rezaei; Sandra Refoua; Najme Esfandiari; Masoud Shamaei

Volume 15, Issue 1 , January 2020, , Pages 1-7


  Background & Objective:Although the antigen expression patterns of acute lymphoblastic leukemia (ALL) are well known, this study attempted to evaluate commonly used immune markers for immunophenotyping of acute leukemia to set the minimum of necessary diagnostic panels by flow cytometry.Methods:This ...  Read More

Mast Cell Leukemia with Ascites and Multiple Organs Damage

Elham Jafari; Ali Hadipour; Behjat Kalantari Khandani; Firoozeh Abolhasani

Volume 14, Issue 3 , August 2019, , Pages 265-269


  Mast Cell Leukemia (MCL), a rare subtype of systemic mastocytosis is defined by bone marrow involvement as atypical and aleukemic mast cells, if more than 20% and less than 10% of peripheral WBCs are mast cells, respectively. We met a case of aleukemic MCL presenting with anemia and ascites for 2 years, ...  Read More

Dengue with Normal Platelet Count and no Hemoconcentration: Automated Hematogram in Cases with Underlying Thalassemia

Beuy Joob; Viroj Wiwanitkit

Volume 14, Issue 2 , April 2019, , Pages 186-187


  Dear Editor, Dengue is an important arbovirus infection. This infection can result in an acute febrile illness. The important hematological abnormalities included hemoconcentration and thrombocytopenia (1). Due to the decreased platelet count, the patient might develop petechiae and hemorrhagic complication. ...  Read More

Prevalence of MPL (W515K/L) Mutations in Patients with Negative-JAK2 (V617F) Myeloproliferative Neoplasm in North-East of Iran

Seyyede Fatemeh Shams; Hossein Ayatollahi; Mohammad hadi Sadeghian; Monavar Afzal Aghaee; Sepideh Shakeri; Ehsan Yazdandoust; Maryam Sheikhi; Nafiseh Amini; Samane Bakhshi; Afsane Bahrami

Volume 13, Issue 4 , October 2018, , Pages 397-402

  Background and Objective: Janus kinase 2 (JAK2) and Myeloproliferative Leukemia (MPL) mutations are confirmatory indicators for Myeloproliferative Neoplasm (MPN). The current study was performed to determine the frequency of MPL mutation in MPN patients without JAK2 mutation, in order to assign MPL mutation ...  Read More

Peripheral Blood-Derived Mesenchymal Stem Cells: Growth Factor-Free Isolation, Molecular Characterization and Differentiation

Noushin Pouryazdanpanah; Shahriar Dabiri; Ali Derakhshani; Reza Vahidi; Alireza Farsinejad

Volume 13, Issue 4 , October 2018, , Pages 461-466

  Background and Objectives: The mesenchymal stem cells derived from peripheral blood (PB) have been recognized as a promising source for allogeneic cell therapy. The aim of this study was to investigate the isolation, growth and differentiation ability of peripheral blood-isolated mesenchymal stem cells. ...  Read More

Prognostic Value of EVI1 Expression in Pediatric Acute Myeloid Leukemia: A Systematic Review

Mohammad Hadi Sadeghian; Zahra Rezaei dezaki

Volume 13, Issue 3 , July 2018, , Pages 294-300

  Acute myeloid leukemia (AML) as a distortion of blood cells involves the differentiation of hematopoietic stem cells. Several studies established the irregular overexpression of specific genes is a common finding in patients with AML. The ectopic viral integration site-1 (EVI1) gene is a proto-oncogene ...  Read More

Non Secretory Multiple Myeloma With HCV Infection: A Rare Case Entity

Arun Puri; Heena Wadhwa; Navtej Singh

Volume 13, Issue 2 , April 2018, , Pages 281-284


  Multiple Myeloma is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells. It is characterized by a clinical  pentad of 1) anemia, 2) a monoclonal protein in the serum or the urine or both, 3) bone leisons and or bone pain, 4) hypercalcemia >11.5g/dl and ...  Read More

Cutaneous Verrucous Carcinoma Superimposed on Chronically Inflamed Ileostomy Site Skin: A Case Report

Ali Yaghobi; Payam Azadeh; Behzad Nemati Honar

Volume 13, Issue 2 , April 2018, , Pages 285-288


  Verrucous carcinoma (VC) is a rare variant of well differentiated squamous cell carcinoma (SCC) which is usually found in oral cavity mucosa. Cutaneous verrucous carcinoma is a rare entity and in this paper we report a 43 years old man with VC superimposed on chronically inflamed skin of ileostomy site. ...  Read More

Prognostic Significance of Reduction in Ki67 Index After Neoadjuvant Chemotherapy in Patients With Breast Cancer in Kerman Between 2009 And 2014

Vahid Moazed; Elham Jafari; Behjat Kalantari khandani; Ali Nemati; seyedamir benrazavi

Volume 13, Issue 1 , January 2018, , Pages 71-77


  Background and objective:Breast cancer is the most common malignancy among women. The Neoadjuvant chemotherapy is the treatment of choice for non-operable tumors. The Ki67 is a proliferation marker that can be used to predict the therapeutic response to chemotherapy and the patients' prognosis. Methods: ...  Read More

Beware of Bone Marrow: Incidental Detection and Primary Diagnosis of Solid Tumours in Bone Marrow Aspiration and Biopsies; A Study of 22 Cases

Ruchita Tyagi; Aminder Singh; Bhavna Garg; Neena Sood

Volume 13, Issue 1 , January 2018, , Pages 78-84


  Background & objective: Introduction: First detection of any solid tumour as metastatic deposits in bone marrow directs clinicians to start searching for the primary tumour. Detection of bone marrow metastasis determines the stage of the malignancy, prognosis, mode of treatment, chemotherapeutic ...  Read More

Herpes Simplex Virus and Langerhans Cell Histiocytosis

Maliheh Khoddami; Seyed Alireza Nadji; Paria Dehghanian

Volume 12, Issue 4 , December 2017, , Pages 323-328


  Background and objective: Langerhans cell histiocytosis (LCH) is a rare histiocytic proliferative disorder of unknown etiology and mainly affects young children. The histological feature is granuloma-like proliferation of langerhans-type dendritic cells. Although the possible role of viruses such ...  Read More

Acute Myeloid Leukemia as the Main Cause of Pancytopenia in Iranian Population

Hasan Jalaeikhoo; Seyed Mohammad Hossein Kashfi; Pedram Azimzadeh; Ahmad Narimani; Katayon Gouhari Moghadam; Mohsen Rajaeinejad; Mehdi Ariana; Manouchehr Keyhani

Volume 12, Issue 3 , July 2017, , Pages 265-271


  Background & objective: Pancytopenia is the reduction in the number of all 3 major cellular elements of blood and leads to anemia, leukopenia, and thrombocytopenia. A wide variety of etiologies result in pancytopenia including leukemia, aplastic anemia, and megaloblastic anemia. The current study ...  Read More

Chromogenic in situ Hybridization Compared with Real Time Quantitative Polymerase Chain Reaction to Evaluate HER2/neu Status in Breast Cancer

Hossein Ayatollahi; Azar Fani; Ehsan Ghayoor Karimiani; Fateme Homaee; Arezoo Shajiei; Maryam Sheikh; Sepideh Shakeri; Seyyede Fatemeh Shams

Volume 12, Issue 2 , April 2017, , Pages 128-134


  Background and objective: The assessment of human epidermal growth factor receptor 2 (HER2) status has become of great importance in the diagnosis of breast cancer. The aim of this study was to investigate the diagnostic value of quantitative Polymerase Chain Reaction (qPCR) and Chromogenic In Situ Hybridization ...  Read More

Aggressive Fibromatosis, Clinicopathologic Findings of 25 Cases; A Single-Center Experience and Review of the Literature

Bita Geramizadeh; Fatemeh Jalali

Volume 12, Issue 1 , January 2017, , Pages 20-24


  Background: Aggressive fibromatosis is a rare benign tumor with no potential for metastasis; however, its aggressive nature causes treatment failure and episodes of recurrence. There is no report from Iran about the treatment of this tumor, and all published articles are single-case reports, therefore ...  Read More

Fluorescent in Situ Hybridization and Real-Time Quantitative Polymerase Chain Reaction to Evaluate HER-2/neu Status in Breast Cancer

Fatemeh Homaei Shandiz; Azar Fani; Sepideh Shakeri; Maryam Sheikhi; Abouzar Ramezani Farkhani; Arezoo Shajiei; Hossein Ayatollahi

Volume 12, Issue 1 , January 2017, , Pages 67-73


  Background:Breast cancer remains the most common and second lethal cancer in females. HER-2/neu is one of the most important amplified oncogene in breast cancer. The amplification of HER-2 is correlated with decreased survival, metastasis, and early recurrence.  The amplification of HER-2/neu gene ...  Read More