Iranian Journal of Pathology

Evaluation of the Findings of Peripheral Blood Smear, Bone Marrow Aspiration and Biopsy, Iron Storage, and Immunophenotype in Patients with Chronic Lymphocytic Leukemia

Document Type : Original Research

Authors

Elham Jafari 1
Shiva Didehban 1
Ali Hosseini 2
Parisa Khorasani Esmaili 2

1 Department of Pathology, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

2 Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

https://doi.org/10.30699/ijp.2024.2011275.3170
Abstract
Background & Objective: Chronic lymphocytic leukemia (CLL) is one of the most common types of leukemia in adults with various signs, symptoms, and types of progression. In this study, we have investigated the frequency and correlation of laboratory findings including peripheral blood smear, bone marrow aspiration and biopsy, and cellular immunophenotyping in CLL patients.
Methods: In this cross-sectional and retrospective study, the laboratory information of all 161 patients with definite diagnoses of CLL was extracted, and the frequency and correlation between different laboratory data were analyzed by descriptive statistics methods and Jamovi software version 2022.
Results: Demographic factors such as age and gender, and laboratory factors such as anemia, thrombocytopenia, white blood cell count, percentage of lymphocytes, and patterns of bone marrow involvement were evaluated for 161 patients. There was a significant relationship between the bone marrow iron storage and the percentage of FMC7 marker expression with the percentage of atypical lymphocytes in the peripheral blood.
Conclusion: Chronic lymphocytic leukemia, a prevalent form of leukemia associated with substantial mortality and morbidity, can be detected through a range of diagnostic techniques. Analyzing the results of these diagnostic tests and examining the prevalence of these indicators in patients afflicted with the condition can prove highly beneficial for prompt disease diagnosis, and prognosis determination among affected individuals.

Keywords

Bone marrow cells
Chronic lymphocytic leukemia
Lymphocyte Immunophenotyping

Subjects

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Iranian Journal of Pathology
Volume 19, Issue 2
Spring 2024
Pages 152-159

  • Receive Date 19 September 2023
  • Revise Date 26 January 2024
  • Accept Date 26 January 2024

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