Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Biochemistry
1. The Diagnostic and Prognostic Roles of Combined Expression of Novel Biomarkers in Lung Adenocarcinoma (LUAD) and Lung Squamous Cell Carcinoma (LUSC); An Immunohistochemical Study

Mohamed Alabiad; Ola Harb; Mohamed Abozaid; Ahmed Embaby; Doaa Mandour; Rehab Hemeda; Amany Shalaby

Articles in Press, Accepted Manuscript, Available Online from 21 December 2020

http://dx.doi.org/10.30699/ijp.2020.130944.2452

Abstract
  Background and Objective: Diagnosis and discrimination of lung adenocarcinoma (LUAD) from lung squamous cell carcinoma (LUSC) is critical to select the appropriate treatment regimen as recently targeted therapies require accurate subtyping of NSCLCs. There are currently several biomarkers that could ...  Read More

Biochemistry
2. Expression and Prognostic Significance of Cancer/Testis Antigens, MAGE-E1, GAGE, and SOX-6, in Glioblastoma: An Immunohistochemistry Evaluation

Seyed Abbas Tabatabaei Yazdi; Masoomeh Safaei; Mehran Gholamin; Alireza Abdollahi; Fatemeh Nili; Mehdi Jabbari Nooghabi; Kazem Anvari; Majid Mojarrad

Articles in Press, Accepted Manuscript, Available Online from 20 December 2020

http://dx.doi.org/10.30699/ijp.2020.125038.2368

Abstract
  Background & Objectives: Glioblastoma is the most common primary malignancy of the brain, the prognosis of which is poor. Immunotherapy with cancer/testis (CT) antigens is a novel therapeutic approach for glioblastoma. This study aimed to investigate the expression rate of MAGE-E1, GAGE, and SOX-6 ...  Read More

Hematopathology
3. Matrix metalloproteinase-9 (MMP-9) Expression in Non-Small Cell Lung Carcinoma and Its Association with Clinicopathologic Factors

Amir Hossein Jafarian; Melika Kooshki forooshani; Hossein Reisi; Nema Mohamadian roshan

Volume 15, Issue 4 , Autumn 2020, , Pages 326-333

http://dx.doi.org/10.30699/ijp.2020.95177.1940

Abstract
  Background & Objective:  Matrix metalloproteinases-9 (MMP-9) is one of the most important enzymes to breakdown extracellular matrix which plays a major role in tumor invasion and metastasis. This study aimed to determine tumor MMP-9 expression in non-small-cell lung carcinoma (NSCLC) and ...  Read More

Breast Pathology
4. Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer

Azar Naimi; Maryam Sultan; Elham Amjadi; Parvin Goli; Amirhosein Kefayat

Volume 15, Issue 3 , Summer 2020, , Pages 239-244

http://dx.doi.org/10.30699/ijp.2020.112819.2224

Abstract
  Background & Objective: Our knowledge about correlation of androgen receptor expression and clinicopathological properties of triple-negative breast cancer (TNBC) patients is inadequate, particularly in the Iranian population. The main aim of the present study was to assess the AR expression in TNBC ...  Read More

Uropathology
5. Diagnostic Value of Cytokeratin 34 beta E12 (Ck34βE12) and α-Methylacyl-CoA racemase (AMACR) Immunohistochemical Expression in Prostatic Lesions

Ikram A. Hasan; Hiba Gaidan; Methaq Al-kaabi

Volume 15, Issue 3 , Summer 2020, , Pages 232-238

http://dx.doi.org/10.30699/ijp.2020.113544.2229

Abstract
  Background & Objective:Some prostatic lesions contain small suspicious foci for prostatic carcinoma in which the morphological features are equivocal. Two immunohistochemical markers namely, cytokeratin 34 beta E12 (Ck34βE12) and α-Methylacyl-CoA racemase (AMACR), were evaluated in these ...  Read More

Head and Neck Pathology
6. Cyclin D1 Expression in Patients with Laryngeal Squamous Cell Carcinoma

Vahid Zand; Fariba Binesh; Mojtaba Meybodian; Farzan Safi Dahaj; Arezoo Alamdar yazdi

Volume 15, Issue 3 , Summer 2020, , Pages 245-250

http://dx.doi.org/10.30699/ijp.2020.116579.2276

Abstract
  Background & Objective: Laryngeal squamous cell carcinoma (LSCC) is considered to be one of the most common cancers of the head and neck, accounting for roughly 90% of all malignant tumors of the larynx. To have a timely diagnosis for a better and practical therapy, molecular markers have to be investigated. ...  Read More

Uropathology
7. Sarcomatoid Carcinoma of the Penis: An Uncommon Penile Neoplasm

Sucheta Gandhe; Rahul Patil; Raj Nagarkar

Volume 15, Issue 2 , Spring 2020, , Pages 151-153

http://dx.doi.org/10.30699/ijp.2020.117401.2275

Abstract
  Sarcomatoid squamous cell carcinomas are extremely rare, high grade, aggressive variant of penile cancers. Sarcomatoid carcinoma are biphasic neoplasms with a combination of both sarcomatoid components and carcinomatous elements. These neoplasms are very rare in the urogenital system. We report a 53-year-old ...  Read More

Breast Pathology
8. Assessment of Ki67 in Breast Cancer: A Comparison Between the Eye-10 Method, Stepwise Counting Strategy, and International System of Ki67 Evaluation

Maryam Kadivar; Fatemeh Aram

Volume 15, Issue 1 , Winter 2020, , Pages 13-18

http://dx.doi.org/10.30699/ijp.2019.102290.2017

Abstract
  Background & Objective:Ki-67 evaluation is an essential tool to define luminal A and B breast cancers, which is not yet systematized. The International Ki67 in Breast Cancer Working Group suggests the counting of 500 or 1000 cancer cells, which is a time-consuming process. Therefore, novel methods, ...  Read More

Uropathology
9. Solitary Fibrous Tumor of the Prostate: A Diagnostic Challenge: A Case Report

Nilay Nishith; Monika Gupta; Nidhi Kaushik; Rajeev Sen

Volume 15, Issue 1 , Winter 2020, , Pages 41-44

http://dx.doi.org/10.30699/ijp.2019.104669.2069

Abstract
  Solitary fibrous tumor (SFT) of prostate is an unusual type of mesenchymal neoplasm that can elicit a benign or malignant phenotype. It represents a diagnostic challenge as it can simulate poorly differentiated adenocarcinoma and various mesenchymal neoplasms of prostate. We report a case of prostate ...  Read More

GI, Liver & Pancreas Pathology
10. Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma

Shilpa Tukaram Patil; Clement Wilfred Devadass; Prasanna Shetty Badila

Volume 14, Issue 4 , Autumn 2019, , Pages 317-321

http://dx.doi.org/10.30699/ijp.2019.102982.2028

Abstract
  Background & Objective: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, ...  Read More

11. Prostate Cancer with Intraluminal Inclusions: the Association of the Immunophenotype with Grade Score

Artem Piddubnyi; Anatolii M Romaniuk; Inna-Margaryta Radomychelski; Yuliia Moskalenko; Roman Moskalenko

Volume 14, Issue 3 , Summer 2019, , Pages 212-222

http://dx.doi.org/10.30699/ijp.2019.91400.1884

Abstract
  Background & Objective: To study the immunophenotype of prostate cancer (PC) with the presence and absence of intraluminal inclusions (IIn), depending on the grade score. Methods: A total of 30 PC samples with IIn (group E) and 30 PC samples without them (group C) were studied. These groups were ...  Read More

Immunology and Serology
12. An Immunohistochemical Study of Cyclin D1 Expression in Astrocytic Tumors and its Correlation with Tumor Grade

Parvin Mahzouni; Fatemeh Taheri

Volume 14, Issue 3 , Summer 2019, , Pages 252-257

http://dx.doi.org/10.30699/ijp.2019.82024.1771

Abstract
  Background & Objective: Glioblastoma-multiforme is the high grade form of astrocytic tumors with a short survival time, which are the most common type of brain tumors. Therefore, finding new therapeutic options is essential. Cyclin D1 is expressed in some human malignancies and can be a potential ...  Read More

Diagnostic Pathology
13. Study the Expression of CD10 in Prostate Carcinoma and its Correlation with Various Clinicopathological Parameters

Lalit Singh; Nisha Marwah; Namita Bhutani; Devendra Pawar; Raman Kapil; Rajeev Sen

Volume 14, Issue 2 , Spring 2019, , Pages 135-141

http://dx.doi.org/10.30699/ijp.14.2.135

Abstract
  Background and Objective: Adenocarcinoma of the prostate is the second most common cause of cancer. The loss of CD10 is a common early event in human prostate cancer and is seen in lower Gleason Score malignancies while increased and altered expression is seen in high Gleason Score tumors, lymph nodes ...  Read More

Oral Pathology
14. Histochemical and Immunohistochemical Analysis of Collagen Fibers and Microvascular Density in Various Grades of Oral Submucous Fibrosis

Savita S Thakkannavar; Veena V Naik

Volume 14, Issue 2 , Spring 2019, , Pages 127-134

http://dx.doi.org/10.30699/ijp.14.2.127

Abstract
  Background and Objective: This study was aimed to evaluate the collagen fibers qualitatively and its correlation with microvascular density in various grades of oral submucous fibrosis (OSMF).   Material and Methods: The present study comprised of total 40 cases of oral submucous fibrosis. Picrosirius ...  Read More

Gynecologic Pathology
15. Comparing the Diagnostic Outcomes of Staining Various Breast Lesions with Either Anti-CK 5/6 or Anti-CK 5

Mihir A Gudi; Yiu Yi Chung; Nohadani Mahrokh

Volume 14, Issue 2 , Spring 2019, , Pages 113-121

http://dx.doi.org/10.30699/ijp.14.2.113

Abstract
  Background and Objective: Anti-CK5/6 monoclonal antibodies have an established role in breast disease diagnosis. Anti-CK5 monoclonal antibodies have recently become commercially available. There has been growing interest in the staining characteristics of anti-CK5 and its potential diagnostic role in ...  Read More

Bone & Soft tissue Pathology
16. The Role of Immunohistochemistry Studies in Distinguishing Malignant Mesothelioma from Metastatic Lung Carcinoma in Malignant Pleural Effusion

Monireh Halimi; Samad BeheshtiRouy; Davood Salehi; Seyed Ziaeddin Rasihashemi

Volume 14, Issue 2 , Spring 2019, , Pages 122-126

http://dx.doi.org/10.30699/ijp.14.2.122

Abstract
  Background and Objective: Early diagnosis of malignant pleural mesothelioma (MPM) is the key point of its treatment. The main problem is the precise diagnosis of mesothelioma and its differentiation from metastatic lung adenocarcinoma. Mesothelioma exhibits complex immunohistochemical characteristics. ...  Read More

17. Immunohistochemical Investigation of Mutant BRAF V600E in Common Pigmented Skin Neoplasms, Study on a Sample of Iranian Patients

Maryam Ghasemi; Laleh Vahedi-larijani; Omid Emadian; Jamshid Yazdani; Ahmad Sajadianfar; Saeid Abediankenari

Volume 14, Issue 1 , Winter 2019, , Pages 8-16

http://dx.doi.org/10.30699/ijp.14.1.8

Abstract
  Background & Objective: This study was designed for the first time for the detection of mutant BRAF V600E and its correlation with clinicophathologic features in a sample of Iranian patients with pathologically proved pigmented skin neoplasms.Methods: 82 paraffin-embedded blocks, including melanocytic ...  Read More

18. The Comparison Between Microwave and Autoclave as Antigen Retrieval Methods for Immunohistochemical Detection of CD15 and CD30 in Hodgkin’s Lymphoma

Farid Kosari; Fatemeh Ghaffari

Volume 13, Issue 4 , Autumn 2018, , Pages 390-396

Abstract
  Background and Objective: Hodgkin's lymphoma is a potentially curable hematologic malignancy with difficulty in its diagnosis especially in atypical cases even in expert hands. Today, immunohistochemistry plays a significant role in the diagnosis of it especially applying the anti-CD15 and anti-CD30 ...  Read More

19. Tissue Expression of Prohibition-I and Its Relationship With Prognostic Factors in Breast Cancer

Hossein Javid; Isaac Hashemy; Soudabeh Shahid sales; Nema Mohammadian Roshan; Tayyebeh Kianoosh; Farnaz Zahedi Avval

Volume 13, Issue 2 , Spring 2018, , Pages 237-244

http://dx.doi.org/10.30699/ijp.13.2.237

Abstract
  Background & objective: Globally, breast cancer is the most common malignancy among females. Prohibition (PHB)-I, a homologous protein, was initially introduced as a suppressor gene for amplification process. Further, the protein has a key role in the cell cycle and is capable of inhibiting ...  Read More

20. Assessment of Micro-vessel Density in Brain Glioma by CD105 Expression

Hiva Saffar; Marzieh Mirzaii; Elham Mirzaian2050@gmail.com; Farid Kosari

Volume 13, Issue 2 , Spring 2018, , Pages 205-211

http://dx.doi.org/10.30699/ijp.13.2.205

Abstract
  Background& Objective: Micro-vascular proliferation is an important histological feature of brain glioma with more vascular proliferation is present in higher grades of glioma. CD 105 is expressed in new actively proliferating and immature endothelial cells in tumor environment  and appears ...  Read More

Gynecologic Pathology
21. Ovarian Small Cell Carcinoma: A Rare Case Report and Review of Literature

Savita Agarwal; Megha Ralli; Pinki Pandey; Shruti Singh

Volume 13, Issue 1 , Winter 2018, , Pages 99-102

http://dx.doi.org/10.30699/ijp.13.1.99

Abstract
  Ovarian small cell carcinoma is a rare and highly malignant tumor with poor prognosis. It usually presents in younger females with features of hypercalcemia. The exact histogenesis of the tumor is unclear and it may present as an undifferentiated tumor. In such cases, immunohistochemistry (IHC) plays ...  Read More

22. The diagnostic value of TTF1, P63, HMWK [34βE12], CK7, and CD56 immunostaining in classification of lung carcinoma

Amir Hossein Jafarian; Masoumeh Gharib; Nema Mohammadian Roshan; Samaneh Sherafatnia; Abbas Ali Omidi; Sahar Bagheri

Volume 12, Issue 3 , Summer 2017, , Pages 195-201

http://dx.doi.org/10.30699/ijp.2017.25041

Abstract
  Background & objective: The histologic distinction of small cell from non-small cell lung carcinoma and correct identification of all subtypes of lung carcinoma are very important in treatment management. The main method for histologic classification of lung tumors is based on morphology. However, ...  Read More

23. Evaluation of Immunohistochemistry-Equivocal (2+) HER2 Gene Status in Invasive Breast Cancer by Silver DNA in Situ Hybridization (SISH) and its Association with Clinicopathological Variables

Zaidoon A. Musa; Ban J. Qasim; A.Wahab A.K. Al Shaikhly

Volume 12, Issue 1 , Winter 2017, , Pages 9-19

http://dx.doi.org/10.30699/ijp.2017.21544

Abstract
  Background and Objective:Determination of HER2 gene is crucial in breast carcinoma management and prognosis, as HER2 alterations are linked to a shorter disease-free period, overall survival and resistance to tamoxifen anti-estrogen therapy and other chemotherapy regimens, regardless of the nodal or ...  Read More

24. Hirschsprung Disease Diagnosis: Calretinin Marker Role in Determining the Presence or Absence of Ganglion Cells

Nasser Rakhshani; Mohammadreza Araste; Farid Imanzade; Mahshid Panahi; Fahimeh Safarnezhad Tameshkel; Masoud Reza Sohrabi; Mohammad Hadi Karbalaie Niya; Farhad Zamani

Volume 11, Issue 4 , Autumn 2016, , Pages 409-415

Abstract
  Background: Hirschsprung disease is a complex genetic disorder of the enteric nervous system (ENS), often called congenital aganglionic megacolon and characterized by the absence of enteric neurons along a variable length of the intestine. The definitive diagnosis of Hirschsprung disease relies on histologic ...  Read More

25. Cutaneous Metaplastic Synovial Cyst: A Case Report

Mina Majdi; Hana Saffar; Alireza Ghanadan

Volume 11, Issue 5 , Autumn 2016, , Pages 423-426

Abstract
  Cutaneous metaplastic synovial cyst (CMSC), presents as a solitary, tender subcutaneous nodule that usually occurs at the site of previous surgery or trauma. Histologically, the lesion is characterized by a cystic structure with villous-like projections that lined by metaplastic synovial tissue. The ...  Read More