Document Type : Case Reports


Department of Anatomical and Surgical Pathology and Laboratory Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran


Thyroid gland metastatic tumors are rare in clinical practice. Clear cell RCC is one of common metastatic tumors to thyroid. We here reported a case of incidentally found clear cell renal carcinoma metastasis to the thyroid gland 3 years after nephrectomy, in the thyroidectomy procedure performed for the patient due to the thyroid enlargement caused by multinodular goiter. A 65-year-old Iranian man with a history of multinodular goiter referred to our surgery clinic for thyroidectomy because of compressive effects on the trachea. Patient had a history of nephrectomy due to clear cell RCC 3 years ago. After thyroidectomy, gross and histological examination of thyroid revealed clear cell renal carcinoma metastasis to the thyroid gland in the setting of a multinodular goiter. The diagnosis was confirmed by immunohistochemistry staining. Patients with multinodular goiter are more prone to present with metastasis to thyroid gland if they have a history of malignancy, especially renal cell carcinoma.


Main Subjects

  1. Mohammadi A, Toomatari S, Ghasemi-Rad M. Metastasis from renal cell carcinoma to thyroid presenting as rapidly growing neck mass. Int J Surg Case Rep 2014;5(12):1110-1112. [DOI:10.1016/j.ijscr.2014.09.010] [PMID] [PMCID]
  2. Jackson G, Fino N, Bitting R. Clinical Characteristics of Patients with Renal Cell Carcinoma and Metastasis to the Thyroid Gland. Clin Med Insights Oncol 2017; 11:117955491774398. [DOI:10.1177/1179554917743981] [PMID] [PMCID]
  3. Riaz K, Tunio M, AlAsiri M, Elbagir Mohammad A, Fareed M. Renal Cell Carcinoma Metastatic to Thyroid Gland, Presenting Like Anaplastic Carcinoma of Thyroid. Case Rep Urol 2013;2013:1-4. [DOI:10.1155/2013/651081] [PMID] [PMCID]
  4. Valdez C, Rezaei M, Hendricks F, Knoll S. Metastatic Renal Cell Carcinoma to the Thyroid 23 Years After Nephrectomy. Urol Case Rep 2014;2(4):129-130. [DOI:10.1016/j.eucr.2014.04.002] [PMID] [PMCID]
  5. Lee J, Yang Y, Kim K, Hyun C, Lee J, Koh G et al. A Case of Metastatic Renal Cell Carcinoma to Thyroid Gland. Chonnam Med J 2011;47(2), p.130. [DOI:10.4068/cmj.2011.47.2.130] [PMID] [PMCID]
  6. Sayad S, Ahmadi SA, Moradi M, Nekouian R, Anbari K, Shahsavar F. A meta-analysis on diagnostic accuracy of serum HLA-G level in breast cancer. Expert Review of Precision Medicine and Drug Development. 2020 Mar 3;5(2):109-14. [DOI:10.1080/23808993.2020.1735936]
  7. Khan M, Iyer V, Varshney N. A Rare Case of Metastasis to the Thyroid Gland from Renal Clear Cell Carcinoma 11 Years after Nephrectomy and Concurrent Primary Esophageal Carcinoma. Case Rep Oncol Med 2018; 2018:1-4. [DOI:10.1155/2018/3790106] [PMID] [PMCID]
  8. Villumsen A, Mevik K, Fjøsne H, Brekke M, Haugen O. Late onset metastases to the thyroid gland from renal carcinoma. Tidsskr Nor Laegeforen 2013;133(21):2262-2265. [DOI:10.4045/tidsskr.12.0884] [PMID]
  9. Macedo-Alves D, Koch P, Soares V, Gouveia P, Honavar M, Taveira-Gomes A. Thyroid metastasis from renal cell carcinoma-A case report after 9 years. Int J Surg Case Rep 2015; 16:59-63. [DOI:10.1016/j.ijscr.2015.09.004] [PMID] [PMCID]
  10. Kihara M, Yokomise H, Yamauchi A. Metastasis of renal cell carcinoma to the thyroid gland 19 years after nephrectomy: a case report. Auris Nasus Larynx 2004;31(1):95-100. [DOI:10.1016/j.anl.2003.09.002] [PMID]
  11. Cilengir A, Kalayci T, Duygulu G, Atasever Rezanko T, İnci M. Metastasis of Renal Clear Cell Carcinoma to Thyroid Gland Mimicking Adenomatous Goiter. Pol J Radiol. 2016; 81: 618-621. [DOI:10.12659/PJR.899459] [PMID] [PMCID]
  12. Khairul-Asri MG, Sidhu S, Raja Gopal NS, Azli S, Badawi MA, Hadi S, Fahmy O. Thyrotoxic goiter and asymptomatic thyroid nodule as an initial presentation of clear cell renal cell carcinoma: A report of two cases. Urol Sci 2019;30:238-40
  13. Connolly C. Renal cell metastasis to the thyroid gland: An emerging phenomenon. Int J Surg Case Rep. 2018; 45: 104-106. [DOI:10.1016/j.ijscr.2018.03.032] [PMID] [PMCID]
  14. Kobayashi K, Hirokawa M, Yabuta T, Fukushima M, Masuoka H, Higashiyama T et al. Metastatic carcinoma to the thyroid gland from renal cell carcinoma: role of ultrasonography in preoperative diagnosis. Thyroid Res 8, 4 (2015). [DOI:10.1186/s13044-015-0016-4] [PMID] [PMCID]
  15. Abara, E., Chivulescu, I., Clerk, N., Cano, P. and Goth, A. Recurrent renal cell cancer: 10 years or more after nephrectomy. Can Urol Assoc J 2010; 4(2), p.45. [DOI:10.5489/cuaj.829] [PMID] [PMCID]