Volume 19 (2024)
Volume 18 (2023)
Volume 17 (2022)
Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Prostate Cancer with Intraluminal Inclusions: the Association of the Immunophenotype with Grade Score

Artem Piddubnyi; Anatolii M Romaniuk; Inna-Margaryta Radomychelski; Yuliia Moskalenko; Roman Moskalenko

Volume 14, Issue 3 , August 2019, , Pages 212-222


  Background & Objective: To study the immunophenotype of prostate cancer (PC) with the presence and absence of intraluminal inclusions (IIn), depending on the grade score. Methods: A total of 30 PC samples with IIn (group E) and 30 PC samples without them (group C) were studied. These groups were ...  Read More

Immunology and Serology
An Immunohistochemical Study of Cyclin D1 Expression in Astrocytic Tumors and its Correlation with Tumor Grade

Parvin Mahzouni; Fatemeh Taheri

Volume 14, Issue 3 , August 2019, , Pages 252-257


  Background & Objective: Glioblastoma-multiforme is the high grade form of astrocytic tumors with a short survival time, which are the most common type of brain tumors. Therefore, finding new therapeutic options is essential. Cyclin D1 is expressed in some human malignancies and can be a potential ...  Read More

Gynecologic Pathology
Comparing the Diagnostic Outcomes of Staining Various Breast Lesions with Either Anti-CK 5/6 or Anti-CK 5

Mihir A Gudi; Yiu Yi Chung; Nohadani Mahrokh

Volume 14, Issue 2 , April 2019, , Pages 113-121


  Background and Objective: Anti-CK5/6 monoclonal antibodies have an established role in breast disease diagnosis. Anti-CK5 monoclonal antibodies have recently become commercially available. There has been growing interest in the staining characteristics of anti-CK5 and its potential diagnostic role in ...  Read More

Bone & Soft tissue Pathology
The Role of Immunohistochemistry Studies in Distinguishing Malignant Mesothelioma from Metastatic Lung Carcinoma in Malignant Pleural Effusion

Monireh Halimi; Samad BeheshtiRouy; Davood Salehi; Seyed Ziaeddin Rasihashemi

Volume 14, Issue 2 , April 2019, , Pages 122-126


  Background and Objective: Early diagnosis of malignant pleural mesothelioma (MPM) is the key point of its treatment. The main problem is the precise diagnosis of mesothelioma and its differentiation from metastatic lung adenocarcinoma. Mesothelioma exhibits complex immunohistochemical characteristics. ...  Read More

Oral Pathology
Histochemical and Immunohistochemical Analysis of Collagen Fibers and Microvascular Density in Various Grades of Oral Submucous Fibrosis

Savita S Thakkannavar; Veena V Naik

Volume 14, Issue 2 , April 2019, , Pages 127-134


  Background and Objective: This study was aimed to evaluate the collagen fibers qualitatively and its correlation with microvascular density in various grades of oral submucous fibrosis (OSMF).   Material and Methods: The present study comprised of total 40 cases of oral submucous fibrosis. Picrosirius ...  Read More

Diagnostic Pathology
Study the Expression of CD10 in Prostate Carcinoma and its Correlation with Various Clinicopathological Parameters

Lalit Singh; Nisha Marwah; Namita Bhutani; Devendra Pawar; Raman Kapil; Rajeev Sen

Volume 14, Issue 2 , April 2019, , Pages 135-141


  Background and Objective: Adenocarcinoma of the prostate is the second most common cause of cancer. The loss of CD10 is a common early event in human prostate cancer and is seen in lower Gleason Score malignancies while increased and altered expression is seen in high Gleason Score tumors, lymph nodes ...  Read More

Immunohistochemical Investigation of Mutant BRAF V600E in Common Pigmented Skin Neoplasms, Study on a Sample of Iranian Patients

Maryam Ghasemi; Laleh Vahedi-larijani; Omid Emadian; Jamshid Yazdani; Ahmad Sajadianfar; Saeid Abediankenari

Volume 14, Issue 1 , January 2019, , Pages 8-16


  Background & Objective: This study was designed for the first time for the detection of mutant BRAF V600E and its correlation with clinicophathologic features in a sample of Iranian patients with pathologically proved pigmented skin neoplasms.Methods: 82 paraffin-embedded blocks, including melanocytic ...  Read More

The Comparison Between Microwave and Autoclave as Antigen Retrieval Methods for Immunohistochemical Detection of CD15 and CD30 in Hodgkin’s Lymphoma

Farid Kosari; Fatemeh Ghaffari

Volume 13, Issue 4 , October 2018, , Pages 390-396

  Background and Objective: Hodgkin's lymphoma is a potentially curable hematologic malignancy with difficulty in its diagnosis especially in atypical cases even in expert hands. Today, immunohistochemistry plays a significant role in the diagnosis of it especially applying the anti-CD15 and anti-CD30 ...  Read More

Assessment of Micro-vessel Density in Brain Glioma by CD105 Expression

Hiva Saffar; Marzieh Mirzaii; Elham Mirzaian2050@gmail.com; Farid Kosari

Volume 13, Issue 2 , April 2018, , Pages 205-211


  Background& Objective: Micro-vascular proliferation is an important histological feature of brain glioma with more vascular proliferation is present in higher grades of glioma. CD 105 is expressed in new actively proliferating and immature endothelial cells in tumor environment  and appears ...  Read More

Tissue Expression of Prohibition-I and Its Relationship With Prognostic Factors in Breast Cancer

Hossein Javid; Isaac Hashemy; Soudabeh Shahid sales; Nema Mohammadian Roshan; Tayyebeh Kianoosh; Farnaz Zahedi Avval

Volume 13, Issue 2 , April 2018, , Pages 237-244


  Background & objective: Globally, breast cancer is the most common malignancy among females. Prohibition (PHB)-I, a homologous protein, was initially introduced as a suppressor gene for amplification process. Further, the protein has a key role in the cell cycle and is capable of inhibiting ...  Read More

Gynecologic Pathology
Ovarian Small Cell Carcinoma: A Rare Case Report and Review of Literature

Savita Agarwal; Megha Ralli; Pinki Pandey; Shruti Singh

Volume 13, Issue 1 , January 2018, , Pages 99-102


  Ovarian small cell carcinoma is a rare and highly malignant tumor with poor prognosis. It usually presents in younger females with features of hypercalcemia. The exact histogenesis of the tumor is unclear and it may present as an undifferentiated tumor. In such cases, immunohistochemistry (IHC) plays ...  Read More

The diagnostic value of TTF1, P63, HMWK [34βE12], CK7, and CD56 immunostaining in classification of lung carcinoma

Amir Hossein Jafarian; Masoumeh Gharib; Nema Mohammadian Roshan; Samaneh Sherafatnia; Abbas Ali Omidi; Sahar Bagheri

Volume 12, Issue 3 , July 2017, , Pages 195-201


  Background & objective: The histologic distinction of small cell from non-small cell lung carcinoma and correct identification of all subtypes of lung carcinoma are very important in treatment management. The main method for histologic classification of lung tumors is based on morphology. However, ...  Read More

Evaluation of Immunohistochemistry-Equivocal (2+) HER2 Gene Status in Invasive Breast Cancer by Silver DNA in Situ Hybridization (SISH) and its Association with Clinicopathological Variables

Zaidoon A. Musa; Ban J. Qasim; A.Wahab A.K. Al Shaikhly

Volume 12, Issue 1 , January 2017, , Pages 9-19


  Background and Objective:Determination of HER2 gene is crucial in breast carcinoma management and prognosis, as HER2 alterations are linked to a shorter disease-free period, overall survival and resistance to tamoxifen anti-estrogen therapy and other chemotherapy regimens, regardless of the nodal or ...  Read More

Cutaneous Metaplastic Synovial Cyst: A Case Report

Mina Majdi; Hana Saffar; Alireza Ghanadan

Volume 11, Issue 5 , October 2016, , Pages 423-426

  Cutaneous metaplastic synovial cyst (CMSC), presents as a solitary, tender subcutaneous nodule that usually occurs at the site of previous surgery or trauma. Histologically, the lesion is characterized by a cystic structure with villous-like projections that lined by metaplastic synovial tissue. The ...  Read More

Hirschsprung Disease Diagnosis: Calretinin Marker Role in Determining the Presence or Absence of Ganglion Cells

Nasser Rakhshani; Mohammadreza Araste; Farid Imanzade; Mahshid Panahi; Fahimeh Safarnezhad Tameshkel; Masoud Reza Sohrabi; Mohammad Hadi Karbalaie Niya; Farhad Zamani

Volume 11, Issue 4 , October 2016, , Pages 409-415

  Background: Hirschsprung disease is a complex genetic disorder of the enteric nervous system (ENS), often called congenital aganglionic megacolon and characterized by the absence of enteric neurons along a variable length of the intestine. The definitive diagnosis of Hirschsprung disease relies on histologic ...  Read More

Role of Immunohistochemistry in the Diagnosis of Solitary Fibrous Tumor, a Review

Bita Geramizadeh; Mahsa Marzban; Andrew Churg

Volume 11, Issue 3 , July 2016, , Pages 195-203

  Background: Solitary fibrous tumor (SFT) is a mesenchymal tumor which is most commonly seen in the pleura; however it can be seen in other organs such as the meninge, gastrointestinal tract, soft tissue, bone, and skin. SFT should be differentiated from other mesenchymal tumors in these organs. Immunohistochemistry ...  Read More

Hodgkin Lymphoma and Anaplastic Variants of Non-Hodgkin Lymphoma

Hamid Tabrizchee; Armita Esmaili

Volume 6, Issue 4 , September 2011, , Pages 193-201

    Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic ...  Read More

Immunohistochemical Study of HER2/neu Overexpression in Adenoid Cystic Carcinoma of Salivary Glands

Amir Hossein Jafarian; Jahanshah Salehinejad; Bahareh Joushan; Abbas Ali Omidi

Volume 6, Issue 2 , April 2011, , Pages 86-92

    Background and Objectives: Adenoid cystic carcinoma (ACC), the most common malignant tumor of submandibular and minor salivary glands, is characterized by a high rate of local recurrence and distant hematogenous metastasis and tendency to invade peripheral nerves. In spite of radiotherapy and ...  Read More

The Incidence of EBV in Diffuse Large B-Cell Lymphoma: A Comparative Study of Immunohistochemical and PCR Techniques

Farid Kosari; Naghmeh Amin Taheri; Alireza Sadeghipour; Kamran Alimoghaddam; Ardeshir Ghavamzadeh

Volume 6, Issue 1 , January 2011, , Pages 8-12

    Background and Objectives: Epstein Barr Virus (EBV) is one of the members of herpesviridae family and a sub-category of Gamma herpes virinae. EBV, which normally has CR2 or CD21 receptors on B-lymphocytes, has mutagenic features for them. The virus plays an important role in causing some malignant ...  Read More

Granulosa Cell – Stromal Tumors: An Immunohistochemical Study Including Comparison of Calretinin and Inhibin

Zohreh Yousefi; Nourieh Sharifi; Farnoosh Sadatmand; Soodabeh Shaid Salles

Volume 4, Issue 4 , September 2009, , Pages 172-176

  Background and Objective: Histopathological evaluation of granulosa cell tumors (GCT) of the ovary may be confused morphologically with a wide variety of the tumors. Immunohistochemical staining for inhibin and calretinin can be used for better diagnosis. Although it has been suggested that inhibin can ...  Read More

Fallopian Tube Carcinoma: A Case Report and Review of Litrature

Afsaneh Rajabiani; Hossein Vakili

Volume 4, Issue 4 , September 2009, , Pages 190-193

  Primary fallopian tube carcinoma is a rare tumor that histologically and clinically resembles epithelial ovarian cancer. Here we introduce a case of tubal carcinoma in a postmenopausal woman. The diagnosis of primary fallopian tube carcinoma is rarely considered preoperatively and is usually first appreciated ...  Read More

Kaposifrom Hemangioendothelioma of the Skull in a 3 Year--Old Boy

Seyed Hamid Madani; Etrat Javadi Rad; Ahmad Faramarzi

Volume 4, Issue 3 , June 2009, , Pages 137-140

    Kaposiform hemangioendothelioma (KHE) appears as a single lesion at birth or early infancy in an equal sex ratio. A rare aggressive vascular proliferation has been recognized as a separate entity from other childhood vascular neoplasm. A 3-year-old Iranian boy with a rapidly enlarging mass in ...  Read More

An Immunohistochemical Study Of P63 Protein Expression In Meningioma

N. Sharifi; M. Katebi

Volume 3, Issue 3 , June 2008, , Pages 146-150

    Background and Objective: Histological grading has prognostic and therapeutic implications in meningioma. However, histological criteria are sometimes not fulfilled to predict the biological behavior of meningiomas. P63 gene is a novel P53 family member, known as tumor suppressor factor, with ...  Read More

Expression Of P53 And Ki67 Proteins In Renal Cell Carcinoma And Its Relationship With Nuclear Grade

Sakineh Amouian; Mahdi Farzadnia; Bahram Memar; Armin Attaranzadeh; Naser Tayyebi

Volume 3, Issue 1 , January 2008, , Pages 25-29

  Background and Objective: Evaluation of tumor proliferative activity may provide a predicting parameter to estimate biologic aggression and a subsequent prognosis that has been evaluated in many malignancies. We have selected renal cell carcinoma (RCC) in this study. To determine tumor proliferative ...  Read More

Is “Basal-like” Carcinoma of the Breast a Distinct Clinicopathologic Entity? A Critical Review with Cautionary Notes

Farid Moinfar

Volume 2, Issue 4 , September 2007, , Pages 127-143

  This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma recently known as “basal-like” carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, ...  Read More