Iranian Journal of Pathology

Immunohistochemical Study of HER2/neu Overexpression in Adenoid Cystic Carcinoma of Salivary Glands

Document Type : Original Research

Authors

Amir Hossein Jafarian 1
Jahanshah Salehinejad 2
Bahareh Joushan 3
Abbas Ali Omidi 1

1 Dept. of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

2 Dept. of Oral and Maxillofacial Pathology, Faculty of Dentistry and Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Dept.of Endodontics, Faculty of Dentistry and Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract
 
Background and Objectives: Adenoid cystic carcinoma (ACC), the most common malignant tumor of submandibular and minor salivary glands, is characterized by a high rate of local recurrence and distant hematogenous metastasis and tendency to invade peripheral nerves. In spite of radiotherapy and surgical treatment, the long-term prognosis is dismal. Today, many studies are being conducted using the immunohistochemical markers to help in the evaluation of ACC prognosis. The present investigation was performed to survey immunohistochemically HER2/neu over expression in adenoid cystic carcinoma of salivary glands. Materials and Methods: The 24 existing samples of formalin-fixed paraffin embedded specimen were stained with HER2/neu markers. Tumors with moderate (2+) to strong (3+) complete membrane staining in at least 10% of the tumor cells were scored as positive for over expression. Results: The overall frequency of over expression for HER2/neu was 45.8% and 11 specimen were positive for HER2/neu expression. A significant relationship was found between HER2/neu over expression and grade of ACC. No significant relationship was detected between immunostaining of HER2/neu and histologic pattern. Conclusion: HER2/neu immunostaining might be reliable and useful for evaluation of ACC prognosis.
 

Keywords

Adenoid Cystic Carcinoma
HER2/neu
Immunohistochemistry

  • Receive Date 19 September 2014

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