Head and Neck Pathology
Sahar Assar; Sepideh Assar; Heidar-Ali Mardanifard; Zohreh Jaafari-Ashkavandi
Abstract
Background & Objective: There is no consensus on the prevalence of salivary gland tumors (SGTs) in Iran. Thus, we systematically reviewed the literature about the prevalence of SGTs in Iran and applied the last world health organization (WHO) classification.Methods: The systematic literature search ...
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Background & Objective: There is no consensus on the prevalence of salivary gland tumors (SGTs) in Iran. Thus, we systematically reviewed the literature about the prevalence of SGTs in Iran and applied the last world health organization (WHO) classification.Methods: The systematic literature search was performed in EMBASE, Scopus, PubMed MEDLINE, Google Scholar, Scientific Information Database (SID), and Magiran; we searched for "salivary gland," "tumor," "prevalence," and "Iran" until 1 March 2021. The studies included were written in the English and Farsi languages. The weighted mean prevalence of SGTs was calculated as prevalence (%) * (N/the sum of all N). We used the unpaired Two-sample T-test to compare the weighted means.Results: A total of 17 studies, including 2870 patients, were selected for the data synthesis. The weighted mean prevalence of benign and malignant tumors was 66% (95% CI: 59-73) and 34% (95% CI: 27-41), respectively. The patients' mean age was reported in 10 out of the 17 studies. The weighted mean age of the patients was 40 (95% CI: 37-42) and 49 (95% CI: 43-55) years for benign and malignant tumors, respectively (P=0.01). Pleomorphic adenoma (PA), followed by Warthin's tumor (WT), was the most prevalent benign tumor. Moreover, the most common malignant tumors were mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (AdCC).Conclusion: More than one-third of SGTs in Iran were malignant, which is higher than the reports from Middle Eastern countries. Information about risk factors and the burden of SGTs in Iran is insufficient. Thus, further well-designed longitudinal studies are warranted.
Amir Hossein Jafarian; Jahanshah Salehinejad; Bahareh Joushan; Abbas Ali Omidi
Volume 6, Issue 2 , April 2011, , Pages 86-92
Abstract
Background and Objectives: Adenoid cystic carcinoma (ACC), the most common malignant tumor of submandibular and minor salivary glands, is characterized by a high rate of local recurrence and distant hematogenous metastasis and tendency to invade peripheral nerves. In spite of radiotherapy and ...
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Background and Objectives: Adenoid cystic carcinoma (ACC), the most common malignant tumor of submandibular and minor salivary glands, is characterized by a high rate of local recurrence and distant hematogenous metastasis and tendency to invade peripheral nerves. In spite of radiotherapy and surgical treatment, the long-term prognosis is dismal. Today, many studies are being conducted using the immunohistochemical markers to help in the evaluation of ACC prognosis. The present investigation was performed to survey immunohistochemically HER2/neu over expression in adenoid cystic carcinoma of salivary glands. Materials and Methods: The 24 existing samples of formalin-fixed paraffin embedded specimen were stained with HER2/neu markers. Tumors with moderate (2+) to strong (3+) complete membrane staining in at least 10% of the tumor cells were scored as positive for over expression. Results: The overall frequency of over expression for HER2/neu was 45.8% and 11 specimen were positive for HER2/neu expression. A significant relationship was found between HER2/neu over expression and grade of ACC. No significant relationship was detected between immunostaining of HER2/neu and histologic pattern. Conclusion: HER2/neu immunostaining might be reliable and useful for evaluation of ACC prognosis.
