Iranian Journal of Pathology

Salivary Gland Tumors in Iran: A Systematic Review of 2870 Cases Based on the New WHO Classification

Document Type : Systematic Review

Authors

Sahar Assar 1
Sepideh Assar 1
Heidar-Ali Mardanifard 2
Zohreh Jaafari-Ashkavandi 3

1 School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Department of Mathematics, Yasouj University, Yasouj, Iran.

3 Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

https://doi.org/10.30699/ijp.2023.559121.2942
Abstract
Background & Objective: There is no consensus on the prevalence of salivary gland tumors (SGTs) in Iran. Thus, we systematically reviewed the literature about the prevalence of SGTs in Iran and applied the last world health organization (WHO) classification.
Methods: The systematic literature search was performed in EMBASE, Scopus, PubMed MEDLINE, Google Scholar, Scientific Information Database (SID), and Magiran; we searched for "salivary gland," "tumor," "prevalence," and "Iran" until 1 March 2021. The studies included were written in the English and Farsi languages. The weighted mean prevalence of SGTs was calculated as prevalence (%) * (N/the sum of all N). We used the unpaired Two-sample T-test to compare the weighted means.
Results: A total of 17 studies, including 2870 patients, were selected for the data synthesis. The weighted mean prevalence of benign and malignant tumors was 66% (95% CI: 59-73) and 34% (95% CI: 27-41), respectively. The patients' mean age was reported in 10 out of the 17 studies. The weighted mean age of the patients was 40 (95% CI: 37-42) and 49 (95% CI: 43-55) years for benign and malignant tumors, respectively (P=0.01). Pleomorphic adenoma (PA), followed by Warthin's tumor (WT), was the most prevalent benign tumor. Moreover, the most common malignant tumors were mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (AdCC).
Conclusion: More than one-third of SGTs in Iran were malignant, which is higher than the reports from Middle Eastern countries. Information about risk factors and the burden of SGTs in Iran is insufficient. Thus, further well-designed longitudinal studies are warranted.

Keywords

Adenoid cystic carcinoma
Classification
Mucoepidermoid carcinoma
Neoplasms
Pleomorphic adenoma
Prevalence

Subjects

  1. Reinheimer A, Vieira DSC, Cordeiro MMR, Rivero ERC. Retrospective study of 124 cases of salivary gland tumors and literature review. J Clin Exp Dent. 2019;11(11):e1025-32. [DOI:10.4317/jced.55685] [PMID] [PMCID]
  2. Zhan KY, Khaja SF, Flack AB, Day TA. Benign Parotid Tumors. Otolaryngol Clin North Am. 2016;49(2):327-42. [DOI:10.1016/j.otc.2015.10.005] [PMID]
  3. Speight PM, Barrett AW. Salivary gland tumours: diagnostic challenges and an update on the latest WHO classification. Diagn Histopathol. 2020;26(4):147-58. [DOI:10.1016/J.MPDHP.2020.01.001]
  4. Porcheri C, Meisel CT, Mitsiadis TA. Molecular and cellular modelling of salivary gland tumors open new landscapes in diagnosis and treatment. Cancers (Basel). 2020;12(11):1-24. [PMCID] [DOI:10.3390/cancers12113107] [PMID]
  5. Gao M, Hao Y, Huang MX, Ma DQ, Chen Y, Luo HY, et al. Salivary gland tumours in a northern Chinese population: a 50-year retrospective study of 7190 cases. Int J Oral Maxillofac Surg. 2017;46(3):343-9. [DOI:10.1016/J.IJOM.2016.09.021] [PMID]
  6. Gontarz M, Bargiel J, Gąsiorowski K, Marecik T, Szczurowski P, Zapała J, et al. Epidemiology of Primary Epithelial Salivary Gland Tumors in Southern Poland-A 26-Year, Clinicopathologic, Retrospective Analysis. J Clin Med. 2021;10(8): 1663. [DOI:10.3390/JCM10081663] [PMID] [PMCID]
  7. Xiao HD, Bifulco CB. Cellular and Molecular Pathology. Oral, Head Neck Oncol Reconstr Surg. 2018;57-78. [DOI:10.1016/B978-0-323-26568-3.00002-6]
  8. EI-Naggar A.K., Chan J.K.C., Grandis J.R., Takata T. SP. WHO Classification of Head and Neck Tumours. 2017. 215-20 p.
  9. Seethala RR, Stenman G. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland. Head Neck Pathol. 2017;11(1):55-67. [DOI:10.1007/s12105-017-0795-0] [PMID] [PMCID]
  10. Skálová A, Hyrcza MD, Leivo I. Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands. Head Neck Pathol. 2022;16(1):40-53. [DOI:10.1007/s12105-022-01420-1] [PMID]
  11. Taghavi N, Sargolzaei S, Mashhadiabbas F, Akbarzadeh A, Kardouni P. Salivary gland tumors: A 15- year report from Iran. Turk Patoloji Derg. 2016;32(1):35-9. [DOI:10.5146/tjpath.2015.01336] [PMID]
  12. Jaafari Ashkavandi Z, Ahmadi Sheshdeh Z, Kamali F. Orofacial pathologic lesions in children and adolescents: a clinicopathological study in southern Iran . Iran J Pediatr. 2014;24(3):307-12.
  13. Jaafari Ashkavandi Z, Ashraf MJ, Afandak N. A clinico-pathologic study of 82 intraoral minor salivary gland tumors. Iran Red Crescent Med J. 2011;13(9):563-5. [PMID] [PMCID] [DOI:10.5812/kowsar.20741804.2244]
  14. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1-9. [DOI:10.1186/2046-4053-4-1] [PMID] [PMCID]
  15. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med. 2009;6(7). [PMID] [PMCID] [DOI:10.1371/journal.pmed.1000100]
  16. Hashemi pour MS, Zarei MR, Chamani G, Rad M. Malignant salivary glands tumors in Kerman province: a retrospective study. Dent Res J (Isfahan). 2007;4-10.
  17. Mohtasham N, Saghravanian N, Goli M, Kadeh H. Oral Non Squamous Cell Malignant Tumors in an Iranian Population: a 43 year Evaluation. Asian Pac J Cancer Prev. 2015;16(18):8215-20. [DOI:10.7314/apjcp.2015.16.18.8215] [PMID]
  18. Tabatabai SH, Tafti MA, Rafiei B. Primary malignant epithelial salivary gland tumors in an Iranian population: A retrospective study of 81 cases. J Oral Maxillofac Pathol. 2015;19(1):47-52. [DOI:10.4103/0973-029X.157201] [PMID] [PMCID]
  19. Checklist for Systematic Reviews and Research Syntheses Critical Appraisal Checklist for Systematic Reviews and Research Syntheses 2. 2017.
  20. Chinipardaz Z, Khalili M. Salivary Gland Tumors : A retrospective study of 339 cases in an Iranian population from 1986 to 2006. Idjsr. 2013;1(3):19-23.
  21. Khajavi M, Peyvandi A, Naghibzadeh B, Roozbahani NA. Salivary Gland Tumors in Patients Referring to Loghman Hakim Hospital in a 10-Year Period. Res Bull Med Sci. 2010;15(1):45.
  22. Rahrotaban S, Masoomi P, Moradi M, Sharifpour Vajari S. Frequency of salivary gland tumors in two referral center of Qazvin University of Medical sciences from 1999 to 2009. J Res Dent Sci. 2010;7(2):27.
  23. Torabinia N, Khalesi S. Clinicopathological study of 229 cases of salivary gland tumors in Isfahan population. Dent Res J (Isfahan). 2014;11(5):559-63.
  24. Valizadeh Y, Mohagheghi M. Review of 103 Cases of Minor Salivary Gland Tumors.nActa Medica Iranica. 1995;33: 22-6.
  25. Movahedian B, Noori R, Rezaei M. Epidemiology of salivary gland lesions in reffering patients to Isfahan University of Medical Sciences Hospitals 1998-2003. J Isfahan Dent Sch. 2008; 3: 44-137.
  26. Shamloo N, Ghanadan A, Hashemian FS, Ghorbanpour M. Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population. Shiraz E Med J. 2021;(9). [DOI:10.5812/semj.107675]
  27. Ansari MH. Salivary Gland Tumors in an Iranian Population: A Retrospective Study of 130 Cases. J Oral Maxillofac Surg. 2007;65(11):2187-94. [DOI:10.1016/j.joms.2006.11.025] [PMID]
  28. Atarbashi Moghadam S, Atarbashi Moghadam F, Dadfar M. Epithelial salivary gland tumors in ahvaz, southwest of iran. J Dent Res Dent Clin Dent Prospects. 2010;4(4):120-3.
  29. Rezaei F, Tavakoli P, Mozaffari HR, Azari M. Prevalence of salivary gland tumors in patients referred-pathology departments of kermanshah hospitals, Iran, 2007-2012. Res J Med Sci. 2016;10(5):487-91.
  30. Baghaei F, Mohammad Gholi Mezerji N, Shojaei S, Amirian M. Evaluation of Salivary Glands Lesions Frequency in Pathology Centers of Hamadan Dental Faculty and Besat Hospital from 2006 to 2017. Pajouhan Sci J. 2019;17(2):45-53. [DOI:10.21859/psj.17.2.45]
  31. Saravani S, Kadeh H, Farhad-Mollashahi L, Rubin R. Clinicopathological Evaluation of Salivary Gland Lesions in the Southeast of Iran. J Isfahan Dent Sch. 2016;12:30-122.
  32. Jaafari-Ashkavandi Z, Ashraf MJ, Moshaverinia M. Salivary gland tumors: A clinicopathologic study of 366 cases in southern Iran. Asian Pacific J Cancer Prev. 2013;14(1):27-30. [DOI:10.7314/APJCP.2013.14.1.27] [PMID]
  33. Al-Khiro FI. View of Salivary gland tumors: A review of 171 cases, with particular reference to histological types, site, age and gender distribution. J Bagh Coll Dent. 2014;26(1):88-91. [DOI:10.12816/0015170]
  34. Al Sarraj Y, Nair SC, Al Siraj A, AlShayeb M. Characteristics of salivary gland tumours in the United Arab Emirates. Ecancermedicalscience. 2015;9. [DOI:10.3332/ecancer.2015.583] [PMID] [PMCID]
  35. Ma'aita JK, Al-kaisi N, Al-tamimi S, Wraikat A. Salivary Gland Tumors in Jordan : A Retrospective Study of 221 Patients. Croat Med J. 1999;40(3):539-42.
  36. Kizil Y, Aydil U, Ekinci Ö, Dilci A, Köybaşioǧlu A, Düzlü M, et al. Salivary gland tumors in Turkey: demographic features and histopathological distribution of 510 patients. Indian J Otolaryngol Head Neck Surg. 2013;65(Suppl 1):112-20. [DOI:10.1007/s12070-012-0594-6] [PMID] [PMCID]
  37. da Silva LP, Serpa MS, Viveiros SK, Sena DAC, de Carvalho Pinho RF, de Abreu Guimarães LD, et al. Salivary gland tumors in a Brazilian population: A 20-year retrospective and multicentric study of 2292 cases. J Cranio-Maxillofacial Surg. 2018;46(12):2227-33. [DOI:10.1016/J.JCMS.2018.09.028] [PMID]
  38. Fomete, Adebayo E, Ononiwu C. Management of salivary gland tumors in a Nigerian tertiary institution. Ann Afr Med. 2015;14(3):148. [DOI:10.4103/1596-3519.152071] [PMID]
  39. Cunha JLS, Hernandez-Guerrero JC, de Almeida OP, Soares CD, Mosqueda-Taylor A. Salivary Gland Tumors: A Retrospective Study of 164 Cases from a Single Private Practice Service in Mexico and Literature Review. Head Neck Pathol. 2020;15(2):523-31. [DOI:10.1007/S12105-020-01231-2] [PMID] [PMCID]
  40. de Ridder M, Balm AJM, Smeele LE, Wouters MWJM, van Dijk BAC. An epidemiological evaluation of salivary gland cancer in the Netherlands ( 1989 - 2010 ). Cancer Epidemiol. 2014;39:14-20. [DOI:10.1016/j.canep.2014.10.007] [PMID]
  41. Sentani K, Ogawa I, Ozasa K, Sadakane A, Utada M, Tsuya T, et al. Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years. J Clin Med. 2019;8(5):566. [DOI:10.3390/JCM8050566] [PMID] [PMCID]
  42. Filho OV de O, Rêgo TJR do, Mendes FH de O, Dantas TS, Cunha M do PSS, Malta CEN, et al. Prognostic factors and overall survival in a 15-year followup of patients with malignant salivary gland tumors: a retrospective analysis of 193 patients. Braz J Otorhinolaryngol. 2020. [DOI:10.1016/J.BJORL.2020.06.016] [PMID] [PMCID]
  43. Galdirs TM, Kappler M, Reich W, Eckert AW, Aspekte A, Speicheldrüsentumore D, et al. Current aspects of salivary gland tumors - a systematic review of the literature. GMS Interdiscip Plast Reconstr Surg DGPW. 2019;8:1-8. [DOI:10.3205/iprs000138]
  44. [cited 2021 14 August]. Available from: http://prisma-statement.org/prismastatement/flowdiagram.aspx
Iranian Journal of Pathology
Volume 18, Issue 1
Winter 2023
Pages 1-11

  • Receive Date 26 July 2022
  • Revise Date 28 September 2022
  • Accept Date 06 November 2022

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