Document Type : Case Reports

Authors

• Mohsen Emami Aleagha ¹
• Etrat Javadi Rad ²
• Siamak Shariat Torbaghan ³

¹ Dept. of Pathology , Kermanshah University of Medical Sciences , Kermanshah, Iran

² -Dept. of Pathology , Kermanshah University of Medical Sciences , Kermanshah, Iran

³ Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran

Abstract

  Littoral cell angioma is a splenic vascular tumor of splenic sinus lining cells that is considered benign in general. This report describes a case of littoral cell angioma with no malignant histological features. The lesion is composed of anastomosing vascular channels resembling splenic sinus; they are lined by endothelial cells which show mitotic activity very rare. Immunohistochemically, the tumor cells were positive for both endothelial (Factor VIII-AG, CD₃₄) and histiocytic markers (KP₁ or CD₆₈). The morphologic and immunohistochemical findings in this tumor confirm the presence of dual (endothelial / histiocytic) characteristics of the reticuloendothelial cells lining the splenic sinus, justifying the term littoral cell angioma.  

Keywords

• Angioma
• Spleen
• Iran