Iranian Journal of Pathology

Lipid Profile in Subjects with Helicobacter pyloriInfection

Document Type : Original Research

Authors

Mohamad Hosein Aarabi 1
Shokofeh Alvani 2
Hassan Ehteram 3

1 Dept. of Clinical Biochemistry, Kashan University of Medical Sciences, Kashan, Iran

2 Dept. of Physiology and Pharmacology, Kashan University of Medical Sciences, Kashan, Iran

3 Dept. of Pathology, Kashan University of Medical Sciences, Kashan , Iran

Abstract
 
Background and Objectives:  Helicobacter pylori cause a chronic gastric infection, and may cause extra gastrointestinal disease. The association between H. pylori infection and serum lipid profiles is still controversial. The aim of this study was to investigate any possible relationship between H. pylori infection and lipid levels.
Materials and Methods: The subjects were 400 volunteer referring to medical centers of Kashan, Iran between December 2005 and March 2006. Helicobacter pylori infection status was determined by assaying serum anti-H. pylori immunoglobulin G antibody. Total cholesterol, HDL-cholesterol, triglyceride concentrations were measured by routine enzymatic methods. The data for H. pylori-seropositive and –seronegative individuals were compared.
Results: Three hundred nineteen subjects (79.8 percent) were H. pylori-seropositive. The serum triglyceride concentration and total cholesterol/HDL-cholesterol ratio were significantly higher in H. pylori-seropositive than H. pylori–seronegative individuals (162.03 vs. 143.88 mg/dl, P<0.05 and 4.27 versus 3.91, P<0.05 respectively).
Conclusion: The findings confirm the existence of a moderate association between H. pylori infection and lipid modulation. It is also possible that H. pylori infection promotes atherosclerosis by acting through changes in lipid profile.
 

Keywords

Helicobacter pylori
Lipid profile
Coronary Heart Disease
Atherosclerosis
serum lipid levels
Iranian Journal of Pathology
Volume 5, Issue 4 - Serial Number 4
Autumn 2010
Pages 199-203

  • Receive Date 20 September 2014

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