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Abdollahi, A., Shoar, S. (2012). Relationships of Serum Level of High- Sensitivity C- Reactive Protein (hs- CRP) and White Blood Cell (WBC) Count with Gamma- Glutamyltransferase among Iranian Healthy Adults. Iranian Journal of Pathology, 7(4), 209-214.
Alireza Abdollahi; Saeed Shoar. "Relationships of Serum Level of High- Sensitivity C- Reactive Protein (hs- CRP) and White Blood Cell (WBC) Count with Gamma- Glutamyltransferase among Iranian Healthy Adults". Iranian Journal of Pathology, 7, 4, 2012, 209-214.
Abdollahi, A., Shoar, S. (2012). 'Relationships of Serum Level of High- Sensitivity C- Reactive Protein (hs- CRP) and White Blood Cell (WBC) Count with Gamma- Glutamyltransferase among Iranian Healthy Adults', Iranian Journal of Pathology, 7(4), pp. 209-214.
Abdollahi, A., Shoar, S. Relationships of Serum Level of High- Sensitivity C- Reactive Protein (hs- CRP) and White Blood Cell (WBC) Count with Gamma- Glutamyltransferase among Iranian Healthy Adults. Iranian Journal of Pathology, 2012; 7(4): 209-214.

Relationships of Serum Level of High- Sensitivity C- Reactive Protein (hs- CRP) and White Blood Cell (WBC) Count with Gamma- Glutamyltransferase among Iranian Healthy Adults

Article 1, Volume 7, Issue 4, Summer 2012, Page 209-214  XML PDF (98 K)
Document Type: Original Research
Authors
Alireza Abdollahi 1; Saeed Shoar2
1Dept. of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
2Development Association for Clinical Study (DACS), Student Scientific Research Center (SSCR), Tehran University of Medical Sciences, Tehran, Iran
Abstract
Background & Objective: There are many common infections and inflammations among people over the world. This demands an affordable and reliable test with high sensitivity/specificity to predict or confirm the diagnosis of such cases in routinely clinical practice. In the present study, we aimed to find any potential correlation between serum levels of GGT and CRP- Q and/or hs- CRP and WBC count as the well- known markers of inflammation in human body.
Materials and Methods: Through a cross- sectional study, serum levels of CRP-Q, hs- CRP, and GGT, in addition to WBC count were measured in 1,500 healthy people, referred to Blood Transfusion Organization from across the country. Data were analyzed after the patients were checked by physical examination for ruling out the presence of any inflammation or other illness. Serum levels of GGT, CRP- Q, hs- CRP, and WBC count were analyzed by SPSS for windows version 16.
Results: Analysis showed a positive linear correlation between CRP- Q and hs- CRP with GGT also confirmed by non- parametric tests.
Conclusion: Serum GGT may be an inflammatory index and a useful marker in approaching to inflammatory diseases.
 
Keywords
Gamma Glutamyltransferase; C- Reactive Protein; White Blood Cell Count
References
  1. Oda E, Kawai R, Watanabe K, Sukumaran V. Prevalence of Metabolic Syndrome Increases with the Increase in Blood Levels of Gamma Glutamyltransferase and Alanine Aminotransferase in Japanese Men and Women. Inter Med 2009; 48: 1343-1350.
  2. Lee DS, Evans JC, Robins SJ, et al. Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study. Arterioscler Thromb Vasc Biol 2007; 27: 127-133.
  3. Misra A. C- Reactive Protein in Young Individuals: Problems and Implications for Asian Indians. Nutrition 2004;20:478–81.
  4. Kim JH, Lee HR, Han AR, Im JA, Lee DC. Relationship between Serum gamma-glutamyltransferase Level and Serum Ferritin Level in Healthy Adults. J Korean Acad Fam Med 2006;27(8):645-51.
  5. Schulman JD, Goodman SI, Mace JW, Patrick AD, Tietze F, Butler EJ. Glutathionuria: inborn error of metabolism due to tissue deficiency of gamma-glutamyl transpeptidase. Biochem. Biophys Res Commun 1975;65(1):68–74.
  6. Yokoyama H. Gamma glutamyl transpeptidase (gammaGTP) in the era of metabolic syndrome in Japanese. Nihon Arukoru Yakubutsu Igakkai Zasshi 2007;42 (3):110–24.
  7. Fraser A, Thinggaard M, Christensen K, Lawlor DA. Alanine aminotransferase, gamma-glutamyltransferase (GGT) and all-cause mortality: results from a population-based Danish twins study alanine aminotransferase, GGT and mortality in elderly twins. Liver Int 2009;29(10):1494-9.
  8. Lee DH, Blomhoff R, Jacobs DR JR. Is serum gamma glutamyltransferase a marker of oxidative stress? Free Radic Res 2004;38: 535–9.
  9. Raulf M, Stüning M, König W. Metabolism of leukotrienes by L-gamma-glutamyl-transpeptidase and dipeptidase from human polymorphonuclear granulocytes. Immunology 1985;55(1):135–47.
  10. Fraser A, Harris R, Sattar N, Ebrahim S, Smith GD, Lawlor DA.Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: analysis of the British women’s heart and health study and meta-analysis. Arterioscler Thromb Vasc Biol 2007;27:2729–35.
  11. Lee DH, Jacobs DR JR.Serum gamma-glutamyltransferase: new insights about an old enzyme. J Epidemiol Community Health 2009;63(11):884-6.
  12.  Targher G, Kendrick J, Smits G, Chonchol M. Relationship between serum gamma-glutamyltransferase and chronic kidney disease in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001-2006. Nutr Metab Cardiovasc Dis 2010;20(8):583-90.
  13.  Strasak AM, Rapp K, Brant LJ, Hilbe W, Gregory M, Oberaigner W, et al. Association of gamma- glutamyltransferase and risk of cancer incidence in men: a prospective study. Cancer Res 2008;68:3970–7.
  14.  Lee DH, Silventoinen K, Hu G, Jacobs DR, Jousilahti P, Sundvall J, et al. Serum gamma glutamyltransferase predicts nonfatal myocardial infarction and fatal coronary heart disease among 28,838 middleaged men and women. Eur Heart J 2006;27:2170–6.
  15.  Ryu S, Chang Y, Kim DI, Kim WS, Suh BS. gamma-Glutamyltransferase as a predictor of chronic kidney disease in nonhypertensive and nondiabetic Korean men. Clin Chem 2007;53:71–7.   
  16.  Lee DH, Jacobs DR Jr, Gross M, Steffes M. Gamma glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem 2003;49:1358–66.
  17.  Lee DH, Steffen LM, Jacobs DR Jr. Association between serum gamma glutamyltransferase and dietary factors: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Clin Nutr 2004;79:600–5.
  18.  Westerbacka J, Corner A, Tiikkainen M, Tamminen M, Vehkavaara S, Häkkinen AM, et al. Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk. Diabetologia 2004;47:1360–9.      
  19.  Lee DH, Steffes M, Jacobs D. Can persistent organic pollutants explain the association between serum gamma-glutamyltransferase and type 2 diabetes?  Diabetologia 2008;51: 402–7.
  20.  Miyatake N, Matsumoto S, MakinoH, Numata T. Comparison of hepatic enzymes between Japanese men with and without metabolic syndrome. Acta Med Okayama 2007; 61:31–4.
  21.  Fraser A, Harris R, Sattar N, Ebrahim S, Davey Smith G, Lawlor DA. Alanine aminotransferase, gamma glutamyltransferase and incident diabetes: the British Women’s Heart and Health Study and meta-analysis. Diabetes Care 2009;32:741–50.
  22. Whitfield JB. Gamma glutamyl transferase. Crit Rev Clin Lab Sci 2001;38:263–355.
  23.  Emdin M, Pompella A, Paolicchi A. Gamma- glutamyltransferase, atherosclerosis, and cardiovascular disease: Triggering oxidative stress within the plaque. Circulation  2005;112:2078–80.
  24.  Paolicchi A, Emdin M, Ghliozeni E, Ciancia E, Passino C, Popoff G, et al. Atherosclerotic plaques contain gamma-glutamyl transpeptidase activity. Circulation 2004;109:1140.
  25.  Bo S, Gambino R, Durazzo M, Guidi S, Tiozzo E, Ghione F, et al. Associations between gamma-glutamyl transferase,metabolic abnormalities and inflammation in healthy subjects from a population-based cohort: A possible implication for oxidative stress. World J Gastroenterol 2005;11:7109–17.
  26. Ulus T, Yildirir A, Demirtas S, Demir O, Sade LE, Bozbas H, et al. Serum gamma-glutamyl transferase activity: A new marker for stent restenosis? Atherosclerosis 2007;195:348–53.
  27.  Strasak AM, Kelleher CC, Klenk J, Brant LJ, Ruttmann E, Rapp K, et al. Longitudinal change in serum gamma-glutamyltransferase and cardiovascular disease mortality: a prospective population-based study in 76,113 Austrian adults. Arterioscler Thromb Vasc Biol 2008;28(10):1857-65.
  28.  Lee YJ, Kim JK, Lee JH, Lee HR, Kang DR, Shim JY. Association of serum gamma-glutamyltransferase with C-reactive protein levels and white blood cell count in Korean adults. Clin Chem Lab Med 2008; 46(10):1410-5.
  29.  Oda E, Kawai R. Comparison between high-sensitivity C- reactive protein (hs- CRP) and white blood cell count (WBC) as an inflammatory component  of  metabolic  syndrome in Japanese. Intern Med 2010;49(2):117-24.
  30.  Lee MY, Koh SB, Koh JH, Nam SM, Shin JY, Shin YG, et al. Relationship between gamma- glutamyltransferase and metabolic syndrome in a Korean population. Diabet Med 2008;25(4):469-75.
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