Document Type: Case Reports

Authors

1 Dept. of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

2 Dept. of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Salivary  gland  tumors  accounts  for  less  than  1%  of  all  tumors.  Minor  salivary  gland  tumors (MSGTs) are uncommon and make up about 10% of all salivary gland neoplasms. The clinical and histopathological distribution of these tumors vary geographically. A case of a 38 yr old man with a minor salivary gland mass at chin region isreported here. The tumor invaded into the anterior surface of the mandible bone and the surrounding soft tissues. The tumor was resected completely with a safe surgical margin of soft tissue and adjacent bone. Histologically, the tumor is characterized by a biphasic pattern, composed of admixture of epithelial and stromal components, associated with cytological atypia and prominent mitoses. The stromal elements are myxoid, chondroid, and osteoid. The chondroid component is more abundant and shows more atypical changes.  Overall,  the  findings  were  interpreted  as  malignant  pleomorphic  adenoma  of  minor salivary glands of buccal mucosa.
 

Keywords

  1. Stenner M, Klussmann JP. Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved. Eur Arch Otorhinolaryngol 2009;266(3):333-41.
  2. Speight PM, Barrett AW. Salivary gland tumours. Oral Dis 2002;8(5):229-40.
  3. Waldron CA, el-Mofty SK, Gnepp DR.Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol 1988;66(3):323-33.
  4. Pires FR, Pringle GA, de Almeida OP, Chen SY. Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol 2007;43(5):463-70.
  5. Pons Vicente O, Almendros Marqués N, Berini Aytés L, Gay Escoda C. Minor salivary gland tumors: A clinicopathological study of 18 cases. Med Oral Patol Oral Cir Bucal 2008;13(9):E582-8.
  6. Buchner A, Merrell PW, Carpenter WM. Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med 2007;36(4):207-14.
  7. Shishegar M, Ashraf MJ, Azarpira N, Khademi B, Hashemi B, Ashrafi A.Salivary gland tumors in maxillofacial region: a retrospective study of 130 cases in a southern Iranian population. Patholog Res Int. 2011;2011:934350.
  8. Dabbs DJ. Diagnostic Immunohistochemistry. 3rd ed. New York:Saunders Elsevier;2010.
  9. Chimona TS, Koutsopoulos AV, Malliotakis P, Nikolidakis A, Skoulakis C, Bizakis JG. Malignant mixed tumor of the nasal cavity. Auris Nasus Larynx 2006;33(1):63-6.
  10. Mag A, Cotulbea S, Marin Horea A, Lupescu S, Drăgănescu V, Doroş C, et al. True Malignant Mixed Tumor (Carcinosarcoma) Of The Parotid Gland – Case Report. TMJ 2010;60(4):338-42.
  11. Akan H, Yildiz L, Unal R. Carcinoma ex pleomorphic adenoma of the minor salivary gland with pulmonary metastasis. Diagn Interv Radiol 2008;14(1):3-5.
  12. M Sherif S. Pleomorphic Adenoma,Immunohistochemistry. Available in: http://emedicine.medscape.com/article/1630933-overview 2009;14, 2009.
  13. Jaafari-Ashkavandi Z, Ashraf MJ, Afandak N. A clinico-pathologic study of 82 intraoral minor salivary gland tumors. Iran Red Crescent Med J 2011;13(9):674-7.
  14. Yih WY, Kratochvil FJ, Stewart JC. Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg 2005;63(6):805-10.
  15. Eveson JW, Cawson RA. Tumors of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases. Oral Pathol 1985;14:500-9.
  16. Toida M, Shimokawa K, Makita H, Kato K, Kobayashi A, Kusunoki Y, et al. Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofac Surg 2005;34(5):528-32.
  17. Wang D, Li Y, He H, Liu L, Wu L, He Z. Intraoral minor salivary gland tumors in a Chinese population: a retrospective study on 737 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104(1):94-100.
  18. Jansisyanont P, Blanchaert RH Jr, Ord RA. Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases. Int J Oral Maxillofac Surg 2002;31(3):257-61.
  19. Seifert G. Update on salivary gland tumors. Rev Esp Patol 1999;32(3):431-5.
  20. Demirag F, Topcu S, Kurul C, Memis L, Altinok T. Malignant pleomorphic adenoma (malignant mixed tumor) of the trachea: a case report and review of the literature. Eur Arch Otorhinolaryngol 2003;260(2):96-9.
  21. Hemmi A, Hiraoka H, Mori Y, Wataya T, Sato H, Jinnai M, et al. Malignant pleomorphic adenoma (malignant mixed tumor) of the trachea. Report of a case. Acta Pathol Jpn 1988;38(9):1215-26.