Iranian Journal of Pathology

Plasmacytoma of the Cervix Possibly Caused by Neglected Pessary: A Case Report and Literature Review

Document Type : Case Reports

Authors

Noviana Nugrohowati 1, 2
Bening Rahimi Titisari 1, 3
Hanggoro Tri Rinonce 1, 3
Rita Cempaka 1, 3
Irianiwati Widodo 1, 2, 3
Tania Kusuma 1, 2

1 Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia

2 Academic Hospital Universitas Gadjah Mada, Yogyakarta, Indonesia

3 Dr. Sardjito General Hospital, Yogyakarta, Indonesia

https://doi.org/10.30699/ijp.2025.2061514.3465
Abstract
Background & Objective: Plasmacytoma is a rare plasma cell dyscrasia marked by localized monoclonal plasma cell proliferation, distinct from multiple myeloma by its lack of systemic symptoms. Extramedullary plasmacytoma (EMP), the rarest form, typically occurs in the upper respiratory tract. Cervical involvement is rare. Chronic inflammation may play a role in the development of cervical plasmacytoma, though this remains unproven for cervical cases.
Case Presentation: We present a unique case of a 74-year-old woman who presented with vaginal bleeding linked to a neglected pessary inserted 15 years earlier. Upon examination, we discovered overgrown tissue with active bleeding. The biopsy revealed a monomorphic plasma cell infiltration, and immunohistochemistry confirmed CD138-positive, BCL2-negative cervical plasmacytoma, a rare occurrence in the cervix.
Conclusion: This case highlights the importance of considering cervical EMP in atypical cytology and suggests a possible link to chronic pessary-induced inflammation. Early diagnosis through histopathology and immunohistochemistry is essential.

Keywords

Plasma Cell Neoplasm
Cervix Uteri
Pessaries
Pathology

Subjects

Copyright © 2026. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license also allows users to adapt, remix, transform, and build upon the material for any purpose, including commercial use.

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Iranian Journal of Pathology
Volume 21, Issue 1
Winter 2026
Pages 121-127

  • Receive Date 27 May 2025
  • Revise Date 12 June 2025
  • Accept Date 16 September 2025

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