Iranian Journal of Pathology

Serum Levels of Coagulation Factors in Patients with Inflammatory Bowel Disease

Document Type : Original Research

Authors

Bahram Memar 1
Ali Moradi 2, 3
Shohreh Khatami 4
Hassan Vosoughinia 5
Mitra Ahadi 5

1 Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

3 Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4 Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5 Department of Gastroenterology and Hepatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

https://doi.org/10.30699/ijp.2025.2061251.3460
Abstract
Background & Objective: Inflammatory bowel diseases (IBD) is described by increased coagulability and prothrombotic state and can be associated with coagulopathies. Although many causes of increased coagulability and thrombosis have been reported in IBD, there is no definitive evidence for most of them. This study aimed to define the changes in Blood Coagulation Factors in patients with IBD compared to healthy controls.
Methods: In this case-control study, serum levels of protein C, protein S, antithrombin III, fibrinogen, and Homocysteine were evaluated in 59 patients with a confirmed IBD, (23 with Crohn disease and 36 with ulcerative colitis) (case group) and 29 healthy individuals (control group) matched for age and gender.
Results & Conclusion: Significant differences were found in all five studied markers between IBD and non-IBD patients (protein C (P=0.033), protein S (P=0.006), antithrombin III (P<0.001), fibrinogen (P=0.016) and Homocysteine ​​(P<0.001)), however, multivariate analysis showed a significant role for only Homocysteine (OR=0.957, 95%CI: 0.93-0.986, P=0.003) in predicting IBD. Regarding the results, it can be alleged that despite the significant difference in the level of Blood Coagulation Factors between the IBD and non-IBD patients, only the serum level of Homocysteine has a predictive role for IBD.

Keywords

Inflammatory bowel disease
IBD
Crohn's disease
Ulcerative colitis
Blood Coagulation Factors

Subjects

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Iranian Journal of Pathology
Volume 21, Issue 1
Winter 2026
Pages 106-110

  • Receive Date 20 May 2025
  • Revise Date 21 July 2025
  • Accept Date 21 September 2025

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