Document Type : Short Communication

Authors

1 Institute of Family Health, Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Institute of Family Health, Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background & Objective: It was declared that COVID-19 might be more severe in symptomatic pregnant patients. This study was conducted to examine the pathological indices of the placenta in pregnant women who were diagnosed with COVID-19.
Methods: A total of 20 COVID-19–positive mothers were enrolled in this study. Detailed placental pathology findings were compared between subjects based on the history of abortion or occurrence of preterm delivery, hypertension, and diabetes.
Results and Conclusion: Intervillositis was the most frequent abnormality of the placenta. There was also a significant association between abortion history and maternal vascular malperfusion (MVM; P=0.02). The placental abnormalities were found to be increased in women with COVID-19, regardless of maternal comorbidities. Further studies are needed to compare the placental pathology between COVID-19–positive women and healthy women. 

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Main Subjects

  1. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2020;2(2):100107. [DOI:10.1016/j.ajogmf.2020.100107] [PMID] [PMCID]
  2. Tug N, Yassa M, Köle E, Sakin Ö, Köle MÇ, Karateke A, Yiyit N, Yavuz E, Birol P, Budak D, Kol Ö. Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. Turk J Obstet Gynecol. 2020;17(3):149. [DOI:10.4274/tjod.galenos.2020.38924] [PMID] [PMCID]
  3. Zambrano LD, Ellington S, Strid P, Galang RR, Oduyebo T, Tong VT, et al. Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status—United States, January 22–October 3, 2020. Morb Mortal Wkly Rep. 2020;69(44):1641. [DOI:10.15585/mmwr.mm6944e3] [PMID] [PMCID]
  4. Cunningham F, Leveno K, Bloom S, Hauth J, Rouse D. Spong. Williams Obstetricia. Mc Graw Hill. Estados Unidos.;25:1059-60.
  5. Chen S, Huang B, Luo DJ, Li X, Yang F, Zhao Y, et al. Pregnancy with new coronavirus infection: clinical characteristics and placental pathological analysis of three cases. Zhonghua bing li xue za zhi. 2020:418-23.
  6. Baergen RN, Heller DS. Placental pathology in Covid-19 positive mothers: preliminary findings. Pediatr Dev Pathol. 2020;23(3):177-80.. [DOI:10.1177/1093526620925569] [PMID] [PMCID]
  7. Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein JA. Placental pathology in COVID-19. American J Clin Pathol. 2020;154(1):23-32. [DOI:10.1093/ajcp/aqaa089] [PMID] [PMCID]
  8. Deniz M, Tezer H. Vertical transmission of SARS CoV-2: a systematic review. J Matern-Fetal Neonatal Med. 2022;35(14):2655-62. [DOI:10.1080/14767058.2020.1793322] [PMID]
  9. Rodrigues C, Baía I, Domingues R, Barros H. Pregnancy and breastfeeding during COVID-19 pandemic: a systematic review of published pregnancy cases. Front Public Health. 2020;8:558144. [DOI:10.3389/fpubh.2020.558144] [PMID] [PMCID]
  10. Zaigham M, Holmberg A, Karlberg ML, Lindsjö OK, Jokubkiene L, Sandblom J, et al. Intrauterine vertical SARS‐CoV‐2 infection: a case confirming transplacental transmission followed by divergence of the viral genome. Bjog. 2021;128(8):1388. [DOI:10.1111/1471-0528.16682] [PMID] [PMCID]
  11. Khong TY, Mooney EE, Ariel I, Balmus NC, Boyd TK, Brundler MA, et al. Sampling and definitions of placental lesions: Amsterdam placental workshop group consensus statement. Archives of pathology & laboratory medicine. 2016;140(7):698-713. [DOI:10.5858/arpa.2015-0225-CC] [PMID]
  12. Khong TY, Mooney EE, Nikkels PG, Morgan TK, Gordijn SJ, editors. Pathology of the placenta: a practical guide. Springer International Publishing; 2019. [DOI:10.1007/978-3-319-97214-5]
  13. Bunnell ME, Koenigs KJ, Roberts DJ, Quade BJ, Hornick JL, Goldfarb IT. Third trimester stillbirth during the first wave of the SARS-CoV-2 pandemic: similar rates with increase in placental vasculopathic pathology. Placenta. 2021;109:72-4. [DOI:10.1016/j.placenta.2021.04.003] [PMID] [PMCID]
  14. Yang Z, Liu Y. Vertical transmission of severe acute respiratory syndrome coronavirus 2: a systematic review. American J Perinatol. 2020;37(10):1055-60. [DOI:10.1055/s-0040-1712161] [PMID] [PMCID]
  15. Patberg ET, Adams T, Rekawek P, Vahanian SA, Akerman M, Hernandez A, et al. Coronavirus disease 2019 infection and placental histopathology in women delivering at term. American J Obstet Gynecol. 2021;224(4):382-e1. [DOI:10.1016/j.ajog.2020.10.020] [PMID] [PMCID].