Document Type: Case Reports

Authors

1 Department of Gynecology and Obstetrics, School of medicine, Bushehr university of medical sciences, Bushehr, Iran

2 Department of Pathology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

Abstract

Ovarian cancer is the most lethal gynecologic malignancy. The surface epithelial tumor is the most common type of ovarian cancer. Among these, the mucinous tumors account for 10-15% of ovarian tumors. Mucinous ovarian tumors are among the most difficult ovarian neoplasms for surgical pathologists to interpret. Mucinous tumors sometimes coexist with other surface epithelial tumors. Therefore, making the accurate diagnosis of the mucinous tumors is essential. On the other hand, association of Brenner tumors with other neoplasms is rare. Ovarian Brenner tumor has always been discussed by pathologists as an enigmatic tumor, because of its rarity and disputed histogenesis. Here, we reported a case of large mucinous cystadenoma with Brenner component.

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Main Subjects

  1. Alan H.D, Lauren N, Neri L, Ashley S.R. Current Diagnosis and Treatment Obstetrics and Gynecology. 11th ed. Under the united states copyright: McGraw Hill; 2013. p. 848-9.
  2. J S. Berek. Berek & Novak's Gynecology. 15th ed. Lippincott Williams and Wilkins. Philadelphia. USA; 2012. P. 1350-60.
  3. Chen VW, Ruiz B, Killeen JL, Cote TR, Wu XC, Correa CN. Pathology and classification of ovarian tumors. Cancer. 2003; 97:2631‑42. [DOI:10.1002/cncr.11345] [PMID]
  4. Hemalatha AL, Konanahalli P. Bilateral malignant Brenner tumor of ovary. J Obstet Gynecol India. 2005;55:81-2.
  5. Sridevi S, Rao V Manmadha, Kumar S. Satish, Bhagyalakshmi A. Mucinous cystadenoma with Brenner tumor: A Case Report. J Evid-based Med Healthcare. 2015;2(4): 455-458 [DOI:10.18410/jebmh/2015/64]
  6. Clement PB, Young RH. Ovarian Surface Epithelial-Stromal Tumors. In,Mills SE (editor). Sternberg's Diagnostic Surgical Pathology, 5th ed. Philadelphia, Lippincott Williams and Wilkins, A.Wolters Kluwer business. 2010, 2278-2308
  7. Choudhury ND, Kadri MS, Reshi R, Besina S, Laharwal MA, Tasleem R, et al. Bilateral malignant Brenner tumor. JK Sci 2002; 4:215-7
  8. Joh K, Aizawa S, Ohkawa K, Dohzono H, Aida S, Ohgoshi E. Case report of a malignant Brenner tumor with hyperestrogenism. Pathol Int. 1995; 45:75-84. [DOI:10.1111/j.1440-1827.1995.tb03382.x] [PMID]
  9. Berge T, Borglin N.E. Brenner tumors. Histogenetic and clinical studies. Cancer 1967; 20:308-13 https://doi.org/10.1002/1097-0142(1967)20:23.0.CO;2-W [DOI:10.1002/1097-0142(1967)20:23.0.CO;2-W]
  10. Yoonessi M, Abell MR. Brenner tumor of the ovary. Obstetric Gynecol. 1979; 54:90-96 [DOI:10.1097/00006250-197907000-00021] [PMID]
  11. Pradhan P, Mohanty L, Pradhan D, Pujari S, Kar A. Benign brenner tumor of ovary with mucinous cystadenoma: A case report. Asia J Pharmaceutic Health Sci. 2017; 7:1643-6.
  12. Tafe LJ, Muller KE, Ananda G, et al. Molecular Genetic Analysis of Ovarian Brenner Tumors and Associated Mucinous Epithelial Neoplasms: High Variant Concordance and Identification of Mutually Exclusive RAS Driver Mutations and MYC Amplification. Am J Pathol. 2016;186(3):671-677. doi:10.1016/j.ajpath.2015.11.008 [DOI:10.1016/j.ajpath.2015.11.008] [PMID] [PMCID]
  13. Gaur JH, Hassan MJ, Elahi AA, Khetrapal S, Khan S, Jetley S. Synchronous benign Brenner's tumor of ovary with leiomyoma and endometrial adenocarcinoma in a postmenopausal female. J Can Res Ther 2019;15:1418-20 [DOI:10.4103/jcrt.JCRT_109_18] [PMID]
  14. Sharma M, Khangar B, Mallya V, Khurana N, Gupta S. Coexisting Brenner tumor and endometrial carcinoma. J Midlife Health 2017;8:89-91. [DOI:10.4103/jmh.JMH_3_17] [PMID] [PMCID]
  15. Borah T, Mahanta RK, Bora BD, Saikia S. Brenner tumor of ovary: An incidental finding. J Midlife Health 2011;2:40-1 [DOI:10.4103/0976-7800.83273] [PMID] [PMCID]