Lymphoepithelial – Like Carcinoma with Papillary Transitional Cell Carcinoma of the Urinary Bladder Associated with Carcinoma in situ Changes of the Urothelium; A Case Report and Review of Literature

Document Type: Case Reports


1 M.D, FCAP, Assistant professor of Pathology, Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

2 M.D, Department of Pathology, Beheshti Hospital, Shiraz, Iran

3 M.D, Professor of Pathology, Department of Pathology and Hematology Research Center, Shiraz University of Medical sciences, Shiraz, Iran

4 M.D, Pasteur Pathobiology Laboratory, Shiraz, Iran



Lymphoepithelial - like carcinoma, is rarely recognized in the urinary bladder and less commonly occurs with papillary transitional cell carcinoma i.e. mixed pattern. Also, less uncommon is the occurrence of carcinoma in situ changes in the adjacent urothelium of these tumors. Here, a case of lymphoepithelial – like carcinoma and papillary transitional cell carcinoma associated with carcinoma in situ changes of urothelium of the urinary bladder has been reported the prognosis of this type of malignancy as well as its management will be discussed. Meanwhile, immunohistochemical stains have been carried out to differentiate it from lymphoma of the urinary bladder and the findings will be discussed.


Main Subjects

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