Document Type: Case Reports
Dept. of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India
Dept. of Pathology, Armed forces Hospital, Muscat, Oman
Dept. of Obstetrics and Gynaecology, Melaka Manipal Medical College (Manipal campus), Manipal University, Manipal, Karnataka, India
Hepatoid variant of yolk sac tumor of ovary is an unusual tumor with an aggressive behavior. It is usually observed in young females, presents with abdominal complaints and is associated with raised α-fetoprotein (AFP) levels. It should be differentiated from other hepatoid tumors involving the ovary. A complete patient evaluation with gross, microscopy, and immunohistochemistry can identify the site of origin to administer appropriate treatment.
The current study reported the case of a 30-year-old married parous female presenting with abdominal distention and pain of two months duration. She had regular menstrual cycles. Based on lab investigations her serum AFP level was markedly raised to 34,244 ng/mL (normal range: 0-9 ng/mL). Computerized tomography (CT) scan showed large lobulated heterogeneous mass in both ovaries and omental, gall bladder, and lung metastasis. A CT guided biopsy of the ovarian mass was done. On histopathology, a differential diagnosis of hepatoid variant of yolk sac tumor, hepatoid carcinoma of ovary and hepatoid tumor arising from gall bladder metastasizing to the ovary were observed. Patient underwent surgery. Per operatively gross ascites with bilateral ovarian mass, extensive omental, pelvic, and gall bladder deposits were observed. Bilateral salpingo-oophorectomy with omental deposit biopsy was conducted. Histopathology along with immunohistochemistry confirmed a diagnosis of hepatoid variant of yolk sac tumor in both ovaries with widespread intra-abdominal metastasis.
- Hepatoid variant of yolk sac tumour of ovary is an unusual tumour with an aggressive behavior.
- It is usually seen in young females, presents with abdominal complaints and is associated with raised α-fetoprotein levels.
- It has to be differentiated from primary hepatoid carcinoma of ovary, metastatic deposits of hepatocellular carcinoma, and metastatic deposits of hepatoid carcinoma occurring in other organs like pancreas, mediastinum, stomach, gall bladder, urinary bladder, lung and kidney.