Squamous Cell Differentiation in Metastatic Papillary Thyroid Carcinoma: Metaplastic

Acosta AM, Pins MR. Papillary thyroid carcinoma with extensive squamous dedifferentiation metastatic to the lung: BRAF mutational analysis as a useful tool to rule out tumor to tumor metastasis. Virchows Arch 2016;468(2):239-42.   https://doi.org/10.1007/s00428-015-1875-8        PMid:26521063

Harada T, Shimaoka K, Katagiri M, Shimizu M, Hosoda Y, Ito K. Rarity of squamous cell carcinoma of the thyroid: autopsy review. World J Surg 1994;18(4):542-6.   https://doi.org/10.1007/BF00353760            PMid:7725742

Katoh R, Sakamoto A, Kasai N, Yagawa K. Squamous differentiation in thyroid carcinoma. With special reference to histogenesis of squamous cell carcinoma of the thyroid. Acta Pathol Jpn. 1989;39(5):306-12.  https://doi.org/10.1111/j.1440-1827.1989.tb02440.x

Klinck GH, Menk KF. Squamous cells in the human thyroid. Mil Surg. 1951;109(4):406-14.     https://doi.org/10.1093/milmed/109.4.406

Rosai J. Rosai and Ackerman's Surgical Pathology. 10ed. Philadelphia PA: Elsevier; 2011.

Kunisue H, Mikami Y, Tanaka K, Sonoo H, Udagawa K, Yamamoto Y, et al. Metastatic papillary thyroid carcinoma of the submandibular lymph nodes with extensive squamous metaplasia: report of a case. Surg Today. 2003;33(10):751-4.    https://doi.org/10.1007/s00595-003-2581-8       PMid:14513322

Bond JA, Wyllie FS, Ivan M, Dawson T, Wynford-Thomas D. A variant epithelial sub-population in normal thyroid with high proliferative capacity in vitro. Mol Cell Endocrinol. 1993;9(2):175-83.      https://doi.org/10.1016/0303-7207(93)90121-Y

Jensen K, Patel A, Larin A, Hoperia V, Saji M, Bauer A, et al. Human herpes simplex viruses in benign and malignant thyroid tumours. J Pathol. 2010;221(2):193-200. https://doi.org/10.1002/path.2701           PMid:20455254   

Thomas D, Liakos V, Michou V, Kapranos N, Kaltsas G, Tsilivakos V, et al. Detection of herpes virus DNA in post-operative thyroid tissue specimens of patients with autoimmune thyroid disease. Exp Clin Endocrinol Diabetes. 2008;116(1):35-9.      https://doi.org/10.1055/s-2007-956171          PMid:18240111

Benvenga S, Alesci S, Trimarchi F, Facchiano A. Homologies of the thyroid sodium-iodide symporter with bacterial and viral proteins. J Endocrinol Invest. 1999;22(7):535-40. https://doi.org/10.1007/BF03343605              PMid:10475151  

Rausch T, Benhattar J, Sutter M, Andrejevic-Blant S. Thyroid carcinoma with papillary and squamous features: report of a case with histogenetic considerations. Pathol Res Pract. 2010;206(4):263-9.       https://doi.org/10.1016/j.prp.2009.05.003      PMid:19493635

Romano RA, Ortt K, Birkaya B, Smalley K, Sinha S. An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate. PLoS One. 2009;4(5):e5623.      https://doi.org/10.1371/journal.pone.0005623     PMid:19461998 PMCid:PMC2680039

Cameselle-Teijeiro J, Abdulkader I, Pérez-Becerra R, Vázquez-Boquete A, Alberte-Lista L, Ruiz-Ponte C et al. BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion? Hum Pathol. 2009;40(7):1029-35.  https://doi.org/10.1016/j.humpath.2008.11.015      PMid:19269016   

Soares P, Trovisco V, Rocha AS, Lima J, Castro P, Preto A, et al.  BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. Oncogene. 2003;22(29):4578-80.     https://doi.org/10.1038/sj.onc.1206706     PMid:12881714

Nowara E, Huszno J, Slomian G, Nieckula J. Skin toxicity in BRAF(V600) mutated metastatic cutaneous melanoma patients treated with vemurafenib. Postepy Dermatol Alergol. 2016;33(1):52-6.     https://doi.org/10.5114/pdia.2015.48045    PMid:26985180 PMCid:PMC4793055