Amir Hossein Jafarian; Abbas Ali Omidi; Ali Shamsa; Saeedeh Khajeh Ahmadi
Volume 8, Issue 2 , April 2013, , Pages 123-126
Abstract
Primitive neuroectodermal tumor (PENETs) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. In more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). Immunohistochemical staining may be required for diagnosis of PENET. The ...
Read More
Primitive neuroectodermal tumor (PENETs) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. In more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). Immunohistochemical staining may be required for diagnosis of PENET. The cells of tumor express CD99, vimentin, NSE, FL1 but do not express Ck, LCA, myogenin, and WT1. We present a 36-year –old female with left –side tender abdominal swelling, and history of trauma to abdominal. CT imaging confirmed a huge solid mass of kidney, also extending into renal pelvis. Histological section of the lesion showed a malignant proliferation of small round cells in rosette-like pattern with foci of necrosis area. Tumor cells expressed high level of CD 99 antigen. The diagnosis of the lesion was primitive neuroectodermal tumors (PNET). Following-up after 6 months showed no recurrence.
Indranil Chakrabarti; Anuradha De; Amita Giri
Volume 6, Issue 3 , June 2011, , Pages 147-152
Abstract
Primitive neuroectodermal tumor (PNET) of kidney is an extremely rare renal neoplasm with only about fifty reported cases in literature. Presumably,of neural crest origin, these tumors behave aggressively and ...
Read More
Primitive neuroectodermal tumor (PNET) of kidney is an extremely rare renal neoplasm with only about fifty reported cases in literature. Presumably,of neural crest origin, these tumors behave aggressively and carry a poor prognosis. We report a case of 22-year old female patient complaining of left loin pain with recurrent hematuria for last 3 months. On clinical examination, the abdomen was soft and no palpable mass was felt. She underwent ultrasonography and com puted tomography, which revealed a left renal mass. A left radical nephrectomy was performed. Histopathological examination of the nephrectomy specimen showed features of primitive neu roectodermal tumor arising from left kidney, which was confirmed by immunohistochemistry (IHC). The patient was treated with post-nephrectomy chemotherapy and was symptom-free at six-month follow-up.
