Mohammad Ali Rajabi; Fatemeh Rajabi; Parvin Rajabi Dehnavi; Mitra Heidarpour
Volume 3, Issue 1 , January 2008, , Pages 15-19
Abstract
Background and Objective: Angiogenesis is a complex program of several steps and it is tightly regulated by pro- and anti-angiogenic factors. Angiogenesis is one of the key elements in cutaneous wound healing and skin cancers. Estrogen seems to have positive modulating effect on cutaneous wound ...
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Background and Objective: Angiogenesis is a complex program of several steps and it is tightly regulated by pro- and anti-angiogenic factors. Angiogenesis is one of the key elements in cutaneous wound healing and skin cancers. Estrogen seems to have positive modulating effect on cutaneous wound healing and this effect may be explained by its angiogenic properties. This study aims to investigate the effect of estrogen on cutaneous wound angiogenesis in rats through histological criteria. Materials and Methods: This was an experimental study which was carried out at Esfahan University of Medical Sciences in August 2007. Forty rats were randomly allocated into two groups and an experimental wound was induced in their skin. Wounds in the case group were treated with daily topical estrogen and gentamicin, while the controls received only topical gentamicin. After 14 days of treatment, biopsies were obtained. Results: Evaluation of wounds through a validated histological scoring system revealed significant difference between control and treated mice. The latter exhibited increased microvasculature and significantly higher scores of angiogenesis. Conclusion: Our study suggests that topical estrogen is able to increase cutaneous wound angiogenesis considering objective histological criteria.
Mitra Heidarpour; Parvin Rajabi; Shervin Pejhan
Volume 2, Issue 2 , April 2007, , Pages 74-76
Abstract
Biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. Clonorchis sinensis and Opisthorchis species are the major biliary liver flukes associated with human disease. Some of these parasites are highly associated with cholangiocarcinoma. ...
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Biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. Clonorchis sinensis and Opisthorchis species are the major biliary liver flukes associated with human disease. Some of these parasites are highly associated with cholangiocarcinoma. This report describes a clinically and epidemiologically unsuspected liver fluke infection associated with cholangiocarcinoma in a middle aged woman from the south shores of Iran, and emphasizes the importance of efforts to discourage raw freshwater fish intake as the route of infection in high risk populations.
