Iranian Journal of Pathology

Metabolic Abnormalities in HIV-Positive Patients Receiving Highly Active Antiretroviral Therapy

Document Type : Original Research

Authors

Amitis Ramezani 1
Minoo Mohraz 2
Mohammad Banifazl 3
Latif Gachkar 4
Sara Jam 2
Ali Eslamifar 1
Farhad Yaghmaie 5
Kambiz Nemati 6
Arezoo Aghakhani 1

1 Dept. of Clinical Research, Pasteur Institute of Iran, Tehran, Iran

2 Iranian Research Center for HIV/AIDS, Tehran, Iran

3 Iranian Society for Support of Patients with Infectious Disease, Tehran, Iran

4 Infectious Diseases Research Center, Shaheed Beheshti Univ. Med. Sci., Tehran, Iran

5 Health Deputy of Shaheed Beheshti Univ. Med. Sci., Tehran, Iran

6 Health Center of Northern Tehran, Shaheed Beheshti Univ. Med. Sci., Tehran, Iran

Abstract
Background and Objective: Dyslipidemia has become a common problem in human immunodeficiency virus (HIV) disease, especially in patients on combination antiretroviral therapy. In this study we aimed to determine the prevalence of dyslipidemia and metabolic abnormalities in 2 groups of HIV infected patients receiving highly active antiretroviral therapy (HAART) and antiretroviral-naive patients. Patients and Methods: Forty HIV infected patients treated by HAART as a case group (6 females and 34 males) with a mean age of 40.7 ± 10 years and 15 HIV naïve as a control group (2 females and 13 males) with a mean age of 38.40 ± 8.3 enrolled in this study. The two groups were well matched in respect to age, sex and CD4 cell counts. A standardized questionnaire with epidemiological, clinical, and therapeutic data was completed by physicians. Blood samples were obtained for metabolic measurements. CD4 positive cell count was measured by f lowcytometry. Results: Levels of total cholesterol, triglycerides, LDL, HDL, lactate, and FBS were elevated in 24%, 37%, 3.7%, 44.4%, 29.6% and 11% of patients respectively. There was a significant difference regarding mean total cholesterol and LDL between treated group and controls (p<0.05). There was also no significant difference between treated group and controls regarding triglyceride, HDL, lactate and FBS levels. Conclusion: Our study demonstrated that metabolic abnormalities are relatively common in HIV-infected patients receiving HAART. Therefore, it is recommended to screen the HIV infected patients on HAART for metabolic disorders, potential of morbidity, and possible long-term cardiovascular risk factors.
 

Keywords

Dyslipidemia
Hyperglycemia
HIV
Highly active antiretroviral therapy
Iranian Journal of Pathology
Volume 2, Issue 4 - Serial Number 4
Autumn 2007
Pages 154-158

  • Receive Date 28 September 2014

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