@article { author = {Ramezani, Amitis and Mohraz, Minoo and Banifazl, Mohammad and Gachkar, Latif and Jam, Sara and Eslamifar, Ali and Yaghmaie, Farhad and Nemati, Kambiz and Aghakhani, Arezoo}, title = {Metabolic Abnormalities in HIV-Positive Patients Receiving Highly Active Antiretroviral Therapy}, journal = {Iranian Journal of Pathology}, volume = {2}, number = {4}, pages = {154-158}, year = {2007}, publisher = {Farname Inc in collaboration with Iranian Society of Pathology}, issn = {1735-5303}, eissn = {2345-3656}, doi = {}, abstract = {Background and Objective: Dyslipidemia has become a common problem in human immunodeficiency virus (HIV) disease, especially in patients on combination antiretroviral therapy. In this study we aimed to determine the prevalence of dyslipidemia and metabolic abnormalities in 2 groups of HIV infected patients receiving highly active antiretroviral therapy (HAART) and antiretroviral-naive patients. Patients and Methods: Forty HIV infected patients treated by HAART as a case group (6 females and 34 males) with a mean age of 40.7 ± 10 years and 15 HIV naïve as a control group (2 females and 13 males) with a mean age of 38.40 ± 8.3 enrolled in this study. The two groups were well matched in respect to age, sex and CD4 cell counts. A standardized questionnaire with epidemiological, clinical, and therapeutic data was completed by physicians. Blood samples were obtained for metabolic measurements. CD4 positive cell count was measured by f lowcytometry. Results: Levels of total cholesterol, triglycerides, LDL, HDL, lactate, and FBS were elevated in 24%, 37%, 3.7%, 44.4%, 29.6% and 11% of patients respectively. There was a significant difference regarding mean total cholesterol and LDL between treated group and controls (p<0.05). There was also no significant difference between treated group and controls regarding triglyceride, HDL, lactate and FBS levels. Conclusion: Our study demonstrated that metabolic abnormalities are relatively common in HIV-infected patients receiving HAART. Therefore, it is recommended to screen the HIV infected patients on HAART for metabolic disorders, potential of morbidity, and possible long-term cardiovascular risk factors.  }, keywords = {Dyslipidemia,Hyperglycemia,HIV,Highly active antiretroviral therapy}, url = {https://ijp.iranpath.org/article_8985.html}, eprint = {https://ijp.iranpath.org/article_8985_ee4d21133ac1eb6d5488c995e9e22d7a.pdf} }