Iranian Journal of Pathology

The Role of P4HB and SOX4 in Prostatic Carcinoma and Their Clinical Significance

Document Type : Original Research

Authors

Marwa Mohammed Dawoud 1
Noha Elkady 1
Rasha Adel Abdelmoneum 2
Ahmed S Ghonaimy 3
Dina Mohamed Allam 1

1 Department of Pathology, Faculty of Medicine, Menoufia University, Shibin Elkom, Egypt

2 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Menoufia University, Shibin Elkom, Egypt

3 Department of Urology, Faculty of Medicine, Menoufia University, Shibin Elkom, Egypt

https://doi.org/10.30699/ijp.2024.2017851.3227
Abstract
Background & Objective: Prostatic adenocarcinoma (PAC) is the second most prevalent cancer and the fifth leading cause of cancer death in men worldwide. Additionally, pathologists may face problems diagnosing it reliably and may need more than one marker. Thus, the search for new immunohistochemical biomarkers becomes mandatory. This study aims to investigate P4HB and SOX4 expression in prostatic carcinoma, their possible roles, and clinical significance.
Methods: This retrospective study included fifty-six cases of PAC and an equal number of nodular prostatic hyperplasia (NPH) that were immunohistochemically stained by P4HB and SOX4. The results of expression were compared between PAC and NPH cases, followed by correlations with available clinicopathological parameters.
Results: There was a highly significant difference between PAC and NPH regarding P4HB and SOX4 expressions in favor of PAC (both P<0.001). ROC curve analysis of the diagnostic power of P4HB showed 79% sensitivity, 76% specificity, 76.5%, and an area under the ROC curve of 0.845, while SOX4 showed (89%, 100%, and 0.946, respectively). P4HB and SOX4 expression showed a direct correlation (P<0.001). Moreover, SOX4 showed a significant inverse relation with ERG (P=0.047). There was a significant correlation between P4HB and SOX4 and Gleason score (P<0.001). Moreover, P4HB expression was significantly associated with lymphovascular invasion (P=0.013), while SOX4 expression showed a significant association with perineural invasion (P=0.05).
Conclusion: SOX4 and P4HB seem to have diagnostic and prognostic value in PAC. While there was a direct correlation between SOX4 and P4HB, an inverse relationship between SOX4 and ERG was detected.

Keywords

Diagnosis
ERG
Prostatic adenocarcinoma
Prognosis
P4HB
SOX4

Subjects

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Iranian Journal of Pathology
Volume 19, Issue 2
Spring 2024
Pages 225-235

  • Receive Date 13 December 2023
  • Revise Date 26 January 2024
  • Accept Date 26 January 2024

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