Iranian Journal of Pathology

Advanced Sinonasal Malignant Melanoma; A Case Report

Document Type : Case Reports

Authors

Parisa Khorasani Esmaili 1
Shahriar Dabiri 1
Ayeh Shamsadini 2
Tooraj Reza Mirshekari 3

1 Department of Pathology, Pathology and Stem Cells Research Center, Afzali Pour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran

2 Department of Otorhinolaryngology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran

3 Department of Pathology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran

https://doi.org/10.30699/ijp.2023.553175.2987
Abstract
Malignant melanoma of the sinonasal area is a rare tumor that arises from melanocytes in the nasal mucosa and is more aggressive than the cutaneous type with a poor prognosis.
We report a 60-year-old female with the initial chief complaint of nasal cavity fullness, continuous epistaxis, and nasal bone deformity in the past two months.
In a primary examination, a black mass was found, and in an excisional biopsy, the pathologist reported sinonasal malignant melanoma, which was confirmed after IHC staining.
In spindle cell tumors of the head and neck area, we should be aware of mucosal malignant melanoma as a differential diagnosis.

Keywords

Epistaxis
Malignant melanoma
Mucosal melanoma
Sinonasal

Subjects

  1. Bhartiya R, Prasad KM. Malignant Melanoma of Nasal Cavity- A Case Report. J Clin Diagn Res. 2015;9(12):ED21-2. [DOI:10.7860/JCDR/2015/17009.6995] [PMID] [PMCID]
  2. Maheshwari V, Jindal A, Ashraf M, Sharma SC. Malignant melanoma of the nasal cavity. Indian J Otolaryngol Head Neck Surg. 2004;56:223-4. [DOI:10.1007/BF02974357] [PMID] [PMCID]
  3. Gilain L, Houette A, Montalban A, Mom T, Saroul N. Mucosal melanoma of the nasal cavity and paranasal sinuses. Eur Ann Otorhinolaryngol Head Neck Dis. 2014;131(6):365-9. [DOI:10.1016/j.anorl.2013.11.004] [PMID]
  4. Kepekci AH, Kig C, Gundogan GI. The evaluation of malignant mucosal melanoma of nasal cavity with a rare occasion. International Journal of Physiology, Pathophysiol Pharmacol. 2018;10(4):139.
  5. Tiwari D, Plater M, Partridge R, Weston-Simons J. Primary malignant melanoma of the nose: a rare cause of epistaxis in the elderly. Age Ageing. 2005 Nov 1;34(6):653-4. [DOI:10.1093/ageing/afi201] [PMID]
  6. Uysal IÖ, Msr M, Polat K, Altuntas EE, Atalar MH, Tuncer E, Müderris S. Primary malignant melanoma of the nasal cavity. J Craniofac Surg. 2012;23(1):e2-5. [DOI:10.1097/SCS.0b013e3182420575] [PMID]
  7. Sari Aslani, F., Safaee, A., Akbarzadeh Jahromi, M., Karami, L. BRAF Mutation Analysis in Primary Acral Melanoma of 41 Cases from South of Iran. Iranian Journal of Pathology, 2021; 16(4): 370-375. [DOI:10.30699/ijp.2021.139458.2523]
  8. Freedman HM, DeSanto LW, Devine KD, Weiland LH. Malignant melanoma of the nasal cavity and paranasal sinuses. Arch Otolaryngol. 1973;97(4):322-5. [DOI:10.1001/archotol.1973.00780010332008] [PMID]
  9. Clifton N, Harrison L, Bradley PJ, Jones NS. Malignant melanoma of nasal cavity and paranasal sinuses: report of 24 patients and literature review. J Laryngol Otol. 2011 May;125(5):479-85. [DOI:10.1017/S0022215110002720] [PMID]
  10. Yousem DM, Li C, Montone KT, Montgomery L, Loevner LA, Rao V, Chung TS, Kimura Y, Hayden RE, Weinstein GS. Primary malignant melanoma of the sinonasal cavity: MR imaging evaluation. Radiographics. 1996;16(5):1101-10. [DOI:10.1148/radiographics.16.5.8888393] [PMID]
  11. Rodríguez Perales MA, Gómez Mendoza MA, Sánchez Marle JF. Melanoma maligno de las mucosas. An. otorrinolaringol. mex. 1992:153-6.
  12. Alves, I S S et al. "Sinonasal Melanoma: A Case Report and Literature Review." Case reports in oncological medicine vol. 2017 (2017): 8201301. doi:10.1155/2017/8201301. [DOI:10.1155/2017/8201301] [PMID] [PMCID]
  13. Alves IS, Berriel LG, Alves RT, Pinto MB, Oliveira CF, Cazzotto AC, et al. Sinonasal melanoma: a case report and literature review. Case Rep Oncol Med. 2017;2017.
  14. Yu H, Liu G. Clinical analysis of 29 cases of nasal mucosal malignant melanoma. Oncol Let. 2015;10(2):1166-70. [DOI:10.3892/ol.2015.3259] [PMID] [PMCID]
  15. Peng RQ, Wu GH, Chen WK, Ding Y, Ma J, Zhang NH, et al. Clinical characteristics and prognosis of primary nasal mucosal melanoma--a report of 44 cases. Ai zheng= Aizheng= Chin J Cancer. 2006;25(10):1284-6.
  16.  
Iranian Journal of Pathology
Volume 18, Issue 3
Summer 2023
Pages 376-379

  • Receive Date 16 October 2022
  • Revise Date 10 April 2023
  • Accept Date 30 May 2023

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