The Study for Diagnostic Value of β-Catenin Immunohistochemistry Marker in Distinction of Aggressive and Non-Aggressive Basal Cell Carcinoma

Rajabi, Parvin; Hydarpoor, Mitra; Maghsoudi, Ahmadreza; Mohaghegh, Fatemeh; Dehghani Mobarakeh, Maryam

doi:10.30699/ijp.14.1.52

The Study for Diagnostic Value of β-Catenin Immunohistochemistry Marker in Distinction of Aggressive and Non-Aggressive Basal Cell Carcinoma

Document Type : Original Research

Authors

Parvin Rajabi ¹

Mitra Hydarpoor ¹

Ahmadreza Maghsoudi ²

Fatemeh Mohaghegh ³

Maryam Dehghani Mobarakeh ⁴

¹ Dept. of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

² Internal Medicine Dept., Isfahan University of Medical Sciences, Isfahan, Iran

³ Dept of Dermatology, Medicine School, Isfahan University of Medical Sciences, Isfahan, Iran

⁴ Resident of Pathology, Dept. of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

https://doi.org/10.30699/ijp.14.1.52

Abstract

Background & Objective: Basal cell carcinoma (BCC) is a common skin cancer arising from the basal layer of the epidermis and its appendages. They are locally invasive, aggressive, and destructive of skin and the surrounding structures. β-Catenin is a multifunctional protein located to the intracellular side of the cytoplasmic membrane coded by the CTNNB1 gene, which maps to chromosome 3p22.1. It has a critical role in cell-to-cell adhesion by linking cadherins to the actin cytoskeleton and has a central role in transcriptional regulation in the Wnt signaling pathway. We evaluated the diagnostic value of the Beta catenin immunohistochemistry marker in distinction of aggressive and non-aggressive Basal cell carcinoma.
Methods: This cross sectional and descriptive-analytical study was done on archived formalin fixed, paraffin embedded tissue blocks in pathology library of Al-Zahra hospital in Isfahan city. We used immunochemistry to determinate the role of β-Catenin in aggressiveness in BCC with higher rate of relapse.
Results: A total of 76 samples were evaluated in two groups (aggressive &none aggressive). The mean percentage of cytoplasmic β-Catenin staining in aggressive group was more significant than the other group (sensitivity: 86.8% specificity: 81.6%, PPV: 81.5% and NPV: 86.1%) and the mean percentage of membranous β-Catenin staining in non-aggressive group were significant more than the aggressive group. Intensity of membranous staining in both groups significant less than normal epithelium.
Conclusion: Cytoplasmic β-Catenin staining in aggressive BCC is more significant than non-aggressive subtypes, so this indicates that the use of β-Catenin IHC marker maybe helpful in the diagnosis of aggressive BCC.

Keywords

beta-Catenin

Carcinoma

Basal Cell

Aggressive Phase

Sensitivity

Specificity