TY - JOUR ID - 33640 TI - The Study for Diagnostic Value of β-Catenin Immunohistochemistry Marker in Distinction of Aggressive and Non-Aggressive Basal Cell Carcinoma JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Rajabi, Parvin AU - Hydarpoor, Mitra AU - Maghsoudi, Ahmadreza AU - Mohaghegh, Fatemeh AU - Dehghani Mobarakeh, Maryam AD - Dept. of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran AD - Internal Medicine Dept., Isfahan University of Medical Sciences, Isfahan, Iran AD - Dept of Dermatology, Medicine School, Isfahan University of Medical Sciences, Isfahan, Iran AD - Resident of Pathology, Dept. of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Y1 - 2019 PY - 2019 VL - 14 IS - 1 SP - 52 EP - 60 KW - beta-Catenin KW - Carcinoma KW - Basal Cell KW - Aggressive Phase KW - Sensitivity KW - Specificity DO - 10.30699/ijp.14.1.52 N2 - Background & Objective: Basal cell carcinoma (BCC) is a common skin cancer arising from the basal layer of the epidermis and its appendages. They are locally invasive, aggressive, and destructive of skin and the surrounding structures. β-Catenin is a multifunctional protein located to the intracellular side of the cytoplasmic membrane coded by the CTNNB1 gene, which maps to chromosome 3p22.1. It has a critical role in cell-to-cell adhesion by linking cadherins to the actin cytoskeleton and has a central role in transcriptional regulation in the Wnt signaling pathway. We evaluated the diagnostic value of the Beta catenin immunohistochemistry marker in distinction of aggressive and non-aggressive Basal cell carcinoma.Methods: This cross sectional and descriptive-analytical study was done on archived formalin fixed, paraffin embedded tissue blocks in pathology library of Al-Zahra hospital in Isfahan city. We used immunochemistry to determinate the role of β-Catenin in aggressiveness in BCC with higher rate of relapse.Results: A total of 76 samples were evaluated in two groups (aggressive &none aggressive). The mean percentage of cytoplasmic β-Catenin staining in aggressive group was more significant than the other group (sensitivity: 86.8% specificity: 81.6%, PPV: 81.5% and NPV: 86.1%) and the mean percentage of membranous β-Catenin staining in non-aggressive group were significant more than the aggressive group. Intensity of membranous staining in both groups significant less than normal epithelium.Conclusion: Cytoplasmic β-Catenin staining in aggressive BCC is more significant than non-aggressive subtypes, so this indicates that the use of β-Catenin IHC marker maybe helpful in the diagnosis of aggressive BCC. UR - https://ijp.iranpath.org/article_33640.html L1 - https://ijp.iranpath.org/article_33640_619aa9ff861ca085e7aabcda70b70e08.pdf ER -