Iranian Journal of Pathology

The Association of Gastritis and Peptic Ulcer With Polymorphisms in the Inflammatory-related Genes IL-4 and IL-10 in Iranian Population

Document Type : Original Research

Authors

Meysam Rezaeishahmirzadi 1
Neda Motamedi Rad 1
Mehdi Kalantar 2
Hossein Ayatollahi 3
Sepideh shakeri 3
Maryam Sheikhi 3
Mohammad Shekari 1

1 Dept. of Medical Genetics, Hormozgan University of Medical Science, Bandarabas, Iran

2 Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Cancer Molecular Pathology Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

https://doi.org/10.30699/ijp.13.2.229
Abstract
Background and Objective: The current study aimed at assessing the relationship between gastritis and peptic ulcer susceptibility and inflammation-related gene polymorphisms in Iranian patients. Gastritis and peptic ulcer are common medical complications with serious outcomes on the quality of life. Inflammatory responses of gastric mucosa are associated with helicobacter pylori, but most infected patients remain asymptomatic. There is strong evidence that inflammatory response is a major part of its etiology.
Methods: The current case-control study aimed at examining genetic polymorphisms in inflammatory cytokines interleukin (IL)-4, and IL-10 using polymerase chain reaction-variable number tandem reaped (PCR-VNTR) and PCR-restriction fragment length polymorphism (RFLP) methods, respectively in 603 genotyped patients admitted to Mohammadi Hospital in Bandar Abbas, Iran (198 patients with gastritis, 84 with peptic ulcer, and 321 patients as controls).
Results: No significant associations were detected in genotype and allele frequencies of IL-10 and IL-4 between the case (with gastritis and peptic ulcer) and control groups.
Conclusion: In conclusion, the results of the analyses suggested that these polymorphisms may not predispose the carriers to gastritis and peptic ulcer development.

Keywords

Interleukin
Gastritis
Polymorphism
Peptic Ulcer

Subjects

Iranian Journal of Pathology
Volume 13, Issue 2
Spring 2018
Pages 229-236

  • Receive Date 17 September 2016
  • Revise Date 21 February 2017
  • Accept Date 05 April 2018

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