Document Type : Original Research
Authors
- Hassan Bazmamoun 1
- Soheila Narimani 2
- Maryam Shokohi 3
- Hossein Esfahani 4
- Ali Reza Soltanian 5
- Alireza Rastgoo Haghi 6
1 Department of Pediatric Gastroenterology, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Neonatal-Perinatal Medicine, Hamadan University of Medical Science, Hamadan, Iran
4 Department of Pediatric Hematology/Oncology, Hamadan University of Medical Science, Hamadan, Iran
5 Department of Biostatistics, Hamadan University of Medical Sciences, Hamadan, Iran
6 Department of Pathology, Hamadan University of Medical Science, Hamadan, Iran
Abstract
Background & Objective: Iron deficiency before birth or in infancy can cause long-term behavioral and neurological disorders. Measuring serum ferritin is an effective way to diagnose iron deficiency but requires significant blood volume from a low birth weight infant. Therefore, the present study was performed to investigate the relationship between serum and urinary ferritin levels in low birth weight infants.
Methods: In this cross-sectional study, 76 infants weighing less than 2500 g were studied. To measure serum ferritin level, 1.5 mL of blood and to measure urinary ferritin level, at least 1 mL of urine was collected from each infant. Then the results were compared. Data analysis was performed using SPSS software version 16, and the significance level was considered less than 0.05.
Results: Out of 76 neonates studied, 51.3% were boys, and 80.3% were premature infants. The mean birth weight of infants was 2056.31±318.74 g, and the mean serum and urinary ferritin levels were 134.77±72.35 and 85.55±70.97 ng, respectively. There was a statistically significant relationship between serum and urinary ferritin levels. Also, serum ferritin and urinary ferritin levels had a statistically significant relationship with birth weight and gestational age. The higher the birth weight as well as the age at birth, the higher the serum ferritin and urinary ferritin.
Conclusion: According to the findings of this study, measurement of urinary ferritin level can be used as a noninvasive tool for iron deficiency screening in low birth weight infants instead of serum ferritin level.
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Main Subjects
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