Iranian Journal of Pathology

Nevus Comedonicus with Epidermolytic Hyperkeratosis: A Case Report

Document Type : Case Reports

Authors

Faezeh Taghavi 1
Sima Davoodi 1
Naser Tayyebi Meibodi 2
Yalda Nahidi 1
Mostafa Izanlu 2

1 Department of Dermatology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

https://doi.org/10.30699/ijp.2022.542761.2767
Abstract
Nevus comedonicus (NC) is a rare developmental anomaly of the folliculosebaceous apparatus, which appears as numerous dilated papules containing firm, darkly pigmented, horny plugs. It appears shortly after birth and mostly before the age of 10; however, late-onset cases have been reported. There is no gender or racial predilection. Moreover, NC can be a component of nevus comedonicus syndrome, a neurocutaneous disorder with skeletal, ocular, and central nervous system abnormalities. EHK properties in NC are not a common finding and are rarely seen in association with each other. This paper reports a healthy, 27-year-old young woman who has been developing numbers of asymptomatic unilateral linear skin lesions on her chest, waist, right thigh, and popliteal fossa in a unilateral linear pattern over ten years. Skin biopsy revealed dilated follicular ostia with orthokeratotic hyperkeratosis, columns of parakeratosis, cornoid flagellation, epidermolytic hyperkeratosis, and mild acanthosis on its wall.

Keywords

Epidermolytic hyperkeratosis
Nevus comedonicus
Rare skin disorders

Subjects

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Iranian Journal of Pathology
Volume 17, Issue 2
Spring 2022
Pages 234-237

  • Receive Date 28 November 2021
  • Revise Date 10 January 2022
  • Accept Date 10 January 2022

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