TY - JOUR ID - 251016 TI - Nevus Comedonicus with Epidermolytic Hyperkeratosis: A Case Report JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Taghavi, Faezeh AU - Davoodi, Sima AU - Tayyebi Meibodi, Naser AU - Nahidi, Yalda AU - Izanlu, Mostafa AD - Department of Dermatology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2022 PY - 2022 VL - 17 IS - 2 SP - 234 EP - 237 KW - Epidermolytic hyperkeratosis KW - Nevus comedonicus KW - Rare skin disorders DO - 10.30699/ijp.2022.542761.2767 N2 - Nevus comedonicus (NC) is a rare developmental anomaly of the folliculosebaceous apparatus, which appears as numerous dilated papules containing firm, darkly pigmented, horny plugs. It appears shortly after birth and mostly before the age of 10; however, late-onset cases have been reported. There is no gender or racial predilection. Moreover, NC can be a component of nevus comedonicus syndrome, a neurocutaneous disorder with skeletal, ocular, and central nervous system abnormalities. EHK properties in NC are not a common finding and are rarely seen in association with each other. This paper reports a healthy, 27-year-old young woman who has been developing numbers of asymptomatic unilateral linear skin lesions on her chest, waist, right thigh, and popliteal fossa in a unilateral linear pattern over ten years. Skin biopsy revealed dilated follicular ostia with orthokeratotic hyperkeratosis, columns of parakeratosis, cornoid flagellation, epidermolytic hyperkeratosis, and mild acanthosis on its wall. UR - https://ijp.iranpath.org/article_251016.html L1 - https://ijp.iranpath.org/article_251016_03860e787ecb3bd617dc399e99e0cce6.pdf ER -