Document Type : Case Reports
Authors
- David Rosero
- Ramiro Alvarez
- Paula Gambó
- María Alastuey
- Alberto Valero
- Nerea Torrecilla
- A. Belén Roche
- Sara Simón
Hospital Universitario Miguel Servet, Zaragoza, Spain
Abstract
Acinic cell carcinoma arising in salivary glands is a rare tumor, accounting for 2% to 5% of the primary neoplasms of the parotid gland. When these tumors are well-differentiated, the neoplasia has innocuous aspect, due to the similarity to normal parotid tissue. This makes the diagnosis difficult. Initially the malignancy of this tumor was uncertain; however, recent studies have declared it as malignant. The female / male ratio is 3:2. The nodule usually presents as solitary and well defined shape. Several authors have used different terms to describe histomorphological patterns of these tumors. Four descriptive categories (solid, microcystic, papillary-cystic and follicular) are useful for pathologists. Here we report a case of a 49 yr old man with a left parotid nodule of 5 cm. Parotidectomy was performed at the Hospital Universitario Miguel Servet, in Zaragoza (Spain). The microscopy showed a tumor with acinic semblance, having the four morphologic patterns previously described. The morphological and immunohistochemical study was consistent with the diagnosis of acinic cell carcinoma.
Keywords
- Franco C, Torres J, Rodríguez P, González I, Volpato R. Carcinoma de células acinares: gradación histológica. Rev Chilena de Cirugía 2003. 55(2):132-5.
- Boukheris H, Curtis RE, Land CE, Dores GM. Incidence of carcinoma of the major salivary glands according to the World Health Organization (WHO) Classification, 1992-2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev 2009;18(11):2899-906.
- Uro-Coste E. WHO classification of salivary gland tumors: Instructions. Ann Pathol 2011;31(5):S95-6.
- Hoffman HT, Karnell LH, Robinson RA, Pinkston JA, Menck HR. National cancer data base report on cancer of the head and neck: acinic cell carcinoma. J Oral Maxillofac Surg 1998; 56:440-3.
- Zermani R, Rammeh S, Farah F, Kourda N, Zeddini AF, Bettaieb E, et al. L’adénocarcinome à cellules acineuses de la parotide de l’enfant (À propos d’une observation). Ann Pathol 2004. Doi: AP-11-2004-HS1-0242-6498-101019-ART155.
- Munteanu MC, Mărgăritescu CL, Cionca L, NiţulescuNC, Dăguci L, Ciucă EM. Acinic cell carcinoma of the salivary glands: a retrospective clinicopathologic study of 12 cases. Rom J Morphol Embryol 2012;53(2):313-20.
- Schwarz S, Zenk J, Müller M, Etl T, Wünsch PH, Hartmann A, et al. The many faces of acinic cell carcinomas of the salivary gland: a study of 40 cases relating histological and immunohistological subtypes to clinical parameters and prognosis. Histopathology 2012;61:395-408.
- Batsakis J, Luna M, El-Naggar A: Histopathologic grading of salivary gland neoplasms: II acinic cell carcinomas. Ann Otol Rhinol Laryngol 1990; 99: 929-33.
- Gete García P, Almodóvar Álvarez C, García Álvarez G, Rodríguez Francos MI, Cerván Rubiales F, Sangó Lamban P. Parotid tumours: correlation between fine needle aspiration biopsy and histological findings. Acta Otorrinolaringol Esp 2006;57:279-82.
- Godwin JT, Foote FW, Frazell EL. Acinic cell adenocarcinoma of the parotid gland: report of twenty-seven cases. Am J Pathol 1954;30:465-77.
- Daneshbod Y, Daneshbod K, Khademi B. Diagnostic difficulties in the interpretation of fine needle aspirate samples in salivary lesions: diagnostic pitfalls revisited. Acta Cytol 2009 Jan-Feb;53(1):53-70.
- Nagel H, Laskawi R, Büter JJ, Schröder M, Chilla R, Droese M. Cytologic diagnosis of acinic-cell carcinoma of salivary glands. Diagn Cytopathol 1997;16(5):402-12.
- Pinto A, Nosé V, Rojas C, Fan YS, Gomez-Fernandez C. Searching for mammary analog secretory carcinoma of salivary gland among its mimics. Mod Pathol 2014;27:30-7.