Jahanbanoo Shahryari; Shahriar Dabiri; Amin Talebi
Volume 7, Issue 4 , September 2012, , Pages 251-255
Abstract
Kimura’s disease (KD) is a chronic inflammatory disorder primarily seen in male Asians during the second and third decades of life. Clinically, it presents as solitary or multiple subcutaneous nodules, predominantly in the head and neck region, typically in the pre auricular region, forehead, and ...
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Kimura’s disease (KD) is a chronic inflammatory disorder primarily seen in male Asians during the second and third decades of life. Clinically, it presents as solitary or multiple subcutaneous nodules, predominantly in the head and neck region, typically in the pre auricular region, forehead, and scalp. The etiology of Kimura disease is still unknown. This disorder should be suspected when the clinical triad of painless unilateral cervical adenopathy, hypereosinophilia, and hyper-IgE is present. We report a case of KD with multiple subcutaneous nodules in the parotid, submandibular and posterior auricular regions, hypereosinophilia and hyper IgE levels.
Hamid Tabrizchi; Shahriar Dabiri; Alireza Soutodehnejad; Bahram Azadeh; Malcolm M.M. Hayes
Volume 2, Issue 1 , January 2007, , Pages 41-44
Abstract
Localized Leishmania Lymphadenitis (L.L.L) is a self limited clinical presentation of cutaneous leishmaniasis. Microscopic findings in L.L.L are very similar to Toxoplasma lymphasenitis. In all cases, an intensive microscopic search should be done for Leishman bodies. In this study, we describe our microscopic ...
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Localized Leishmania Lymphadenitis (L.L.L) is a self limited clinical presentation of cutaneous leishmaniasis. Microscopic findings in L.L.L are very similar to Toxoplasma lymphasenitis. In all cases, an intensive microscopic search should be done for Leishman bodies. In this study, we describe our microscopic findings and results of our immnohistochemical (IHC) study with a panel of monoclonal antibodies against T-Cells, B-Cells, histiocytes, Langerhans cells, and dendritic reticulum cells. Morphologic and immunohistochemical study in this case showed expanded paracortical tissue with many small clusters of epithelioid histiocytes and large reactive B follicles. Immature sinus histiocytosis in subcapsular and trabecular sinuses was also seen.
Shahriar Dabiri; Hamid Najafipour; Saeed Niazmand; Hamid Tabrizchi
Volume 1, Issue 2 , April 2006, , Pages 49-54
Abstract
Background and Objectives: The cause and pathophysiology of rheumatoid arthritis has not been fully understood and an experimental model of this disease is essential for research on the problem. In this research study, establishment and histopathological changes of chronic arthritis due to intra-articular ...
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Background and Objectives: The cause and pathophysiology of rheumatoid arthritis has not been fully understood and an experimental model of this disease is essential for research on the problem. In this research study, establishment and histopathological changes of chronic arthritis due to intra-articular antigen injection was used as a model of experimental rheumatoid arthritis. Materials and Methods: Thirty three New-Zeeland white rabbits were sensitized by subcutaneous injection of combination of methylated bovine serum albumin (MBSA) and Freund’s complete adjuvant (FCA) at days 1 and 14. Sensitized animals at day 28 received intra-articular injections of MBSA. At days 7, 14, 21, and 28 post-injection, excised knee joints were investigated for routine light microscopic changes. Results: It was found out that at day 7 there are fibrinous exudates in the joint space and pericapsular soft tissue, edematous synovial villi, and an intact cartilaginous site of joint. At day 14, lymphoid follicle formation at pericapsular area, short and widening of synovial villi, superficial erosion of joint cartilage (perichondritis) was observed. Thereafter, at day 21 increased secondary lymphoid follicles with active germinal centers at pericapsular areas, papillary hyperplasia of the synovial villi, thinning of the cartilaginous site of joint with mononuclear cellular infiltrates (chondritis) was noted. In addition, day 28 was demarcated by continuation of the chondritis and beginning of osteitis, granulation tissue formation (Pannus) at cartilaginous site of joint, and fibrotic changes of the synovial villi. Rare findings including pseudocyst space and palisading ranuloma at the pericapsular area was also observed. Conclusion: Antigen-induced chronic arthritis in the knee joint of the rabbit is a good experimental model to evaluate the pathogenesis and/or effects of drug interferences in the rheumatoid arthritis.
