Iranian Journal of Pathology

Prognostic Values of Estrogen and Progesterone Expression Receptors in Ovarian Papillary Serous Carcinoma

Document Type : Original Research

Authors

Zohreh Yousefi 1
Shohreh Saeed 1
Nourieh Sharifi 2
Maryam Bahreini 3

1 Dept. of Obstetrics and Gynecology , Mashhad University of Medical Science, Mashhad, Iran

2 . Dept. of Pathology, Mashhad University of Medical Science, Mashhad, Iran.

3 Medical Faculty, Mashhad University of Medical Science, Mashhad, Iran

Abstract
  Background and Objectives: Presence of steroid hormone receptors (estrogen and progesterone) in the tumor tissues of various organs correlates with response to therapy and prognosis. Since their role in ovarian cancer is still controversial, in this study we investigated the expression and prognostic value of the estrogen receptor (ER) and progesterone receptors (PR) in ovarian papillary serous carcinoma (PSC). Material and Methods: In this retrospective study we determined the expression of tissue receptors including tissue samples from 36 patients with stage III ovarian PSC by Immunohistochemistry method. Then ER and PR expression correlated with clinicopathological parameters and possible prognostic impact on ovarian PSC were investigated. Results: The correlation between age and survey of patients with ovarian PSC and expression of steroid receptor was not significant. Although correlation between severity of expression of PR and mortality rate was not meaningful, the relationship between severity of ER expression and mortality rate was significant (P=0.02) Conclusion: The determination of steroid receptor status may offer additional prognostic information in ovarian carcinoma (PSC).  

Keywords

Ovarian Cancer
Estrogen receptor
Progesterone Receptor
Survival

  • Receive Date 29 September 2014

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