Iranian Journal of Pathology

Littoral Cell Angioma: A Morphologic and Immunohistochemical Study

Document Type : Case Reports

Authors

Mohsen Emami Aleagha 1
Etrat Javadi Rad 2
Siamak Shariat Torbaghan 3

1 Dept. of Pathology , Kermanshah University of Medical Sciences , Kermanshah, Iran

2 -Dept. of Pathology , Kermanshah University of Medical Sciences , Kermanshah, Iran

3 Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran

Abstract
  Littoral cell angioma is a splenic vascular tumor of splenic sinus lining cells that is considered benign in general. This report describes a case of littoral cell angioma with no malignant histological features. The lesion is composed of anastomosing vascular channels resembling splenic sinus; they are lined by endothelial cells which show mitotic activity very rare. Immunohistochemically, the tumor cells were positive for both endothelial (Factor VIII-AG, CD34) and histiocytic markers (KP1 or CD68). The morphologic and immunohistochemical findings in this tumor confirm the presence of dual (endothelial / histiocytic) characteristics of the reticuloendothelial cells lining the splenic sinus, justifying the term littoral cell angioma.  

Keywords

Angioma
Spleen
Iran

  • Receive Date 28 September 2014

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