Document Type : Review Article


Dep. of Pathology, University of Miami Miller School of Medicine, Miami, USA


Correct diagnosis and classification of lymphoid neoplasms depends on the integration of morphologic, immunophenotypic and molecular genetic features. The mature small B cell lymphomas despite their overlapping histomorphologies, have different clinical behavior and treatment. In this review, differential diagnosis of this category of tumors and a practical approach based on biomarkers evaluation is discussed.