Iranian Journal of Pathology

A Comparative Study of Atypical Squamous Cells of Undetermined Significance in Pap Smears Followed by Biopsy Results for Determination of Reliable Cytologic Parameters

Document Type : Original Research

Authors

Fariba Abassi 1
Farrokh Ghavam 1
Farahnaz Norouzinia 1
Reza Pourali 2
Monireh Jalvand 2

1 Dept. of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

2 Dept. of Health Education,Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Abstract
  Background and Objective: Microscopic evaluation of cervicovaginal smears (Pap smear) plays an essential role in detection of preneoplastic and neoplastic lesions of uterine cervix. A wide spectrum of changes is seen in Pap smears. Interpretation of intermediate changes which resulting in observation of so- called ASCUS is difficult. ASCUS is defined as a cellular change that is more marked than typical reactive change but lack features diagnostic of intraepithelial neoplasia. The aim of this study was determination of reliable cytological parameters to identifying real nature of ASCUS. Patients and Methods: In this descriptive, cross sectional study, all Pap smears with presence of ASCUS, which followed by biopsy samples in Urmia, ShahidMatahari hospital during March 1999 to December 2002 were reviewed. In this regard, 17 parameters of cytoplasm, nuclei and smear background were considered and data were analyzed by SPSS and Chi Square test. Results: Four parameters of irregular nuclear contour, increased nucleo- cytoplasmic ratio, cytoplasmic vacuolization and dirty background are highly suggestive of dysplasia. Conclusion: It is important to consider that to find out the real nature of ASCUS a group of parameters are more helpful than a single one. In addition, a single Pap smear is not enough for this purpose and further investigationis required.  

Keywords

Papanicolaou test
Cervix Dysplasia
Cancer
Iran
Iranian Journal of Pathology
Volume 4, Issue 3 - Serial Number 3
Summer 2009
Pages 109-112

  • Receive Date 28 September 2014

Home

Guide for Authors

Submit Manuscript

Contact Us