Iranian Journal of Pathology

Frequency of Human T-Cell Lymphotropic Virus (HTLV) Type 1 and 2 Infection in HIV Infected Patients

Document Type : Original Research

Authors

Amitis Ramezani 1
Arezoo Aghakhani 2
Mohammad Banifazl 3
Zahra Boland-Ghamat 4
Maryam Foroughi 4
Latif Gachkar 5
Akbar hadem-Sadegh 1
Minoo Mohraz 4

1 Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran

2 Iranian Society for Support of Patients With Infectious Diseases, Tehran, Iran

3 Dept. of Microbiology, Alzahra University, Tehran, Iran

4 Iranian Research Center for HIV/AIDS, Tehran, Iran

5 Infectious Disease and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract
Background and Objectives: Human T-cell lymphotropic viruses (HTLV) type 1 and 2 are retroviruses that share the same routes of transmission as human immunodeficiency virus (HIV). As a consequence of epidemiologic similarities, HIV and HTLV-1/2 co-infection is frequent. Due to the limited data, this study assessed the seroprevalence of HTLV-1/2 infections in HIV infected patients in Tehran, Iran.
Materials and Methods: This case-control study was carried out in 180 HIV infected patients from Iranian HIV/AIDS Research Center in Tehran and 117 matched healthy controls. The serum samples were checked with enzyme-linked immunosorbent assay (ELISA) for anti HTLV-1/2.
Results: A total of 180 HIV positive patients with mean age 36.9±9.2 years and 117 matched controls were enrolled in the study. All cases and controls were negative for HTLV-1/2 infection.
Conclusion: HTLV-1/2 infection is negligible in HIV infected patients in Tehran, Iran, although intravenous drug use is the most common route of HIV transmission in our study subjects.

Keywords

HTLV-1
HTLV-2
AIDS Virus
  1. Hogan CM, Hammer SM. Host determinants in HIV infection and disease. Part 2: genetic factors and implications for antiretroviral therapeutics. Ann Intern Med 2001 May 15;134(10):978-96.
  2. Nicot C. Current views in HTLV-I-associated adult T-cell leukemia/lymphoma. Am J Hematol 2005 Mar;78(3):232-9.
  3. UNAIDS. Report on the Global AIDS epidemic, 2008. (unaids.org Accessed 09/15/08).
  4. Li HC, Biggar RJ, Miley WJ, Maloney EM, Cranston B, Hanchard B, et al. Provirus load in breast milk and risk of mother-to-child transmission of human T lymphotropic virus type I. J Infect Dis 2004 Oct 1;190(7):1275-8.
  5. Iga M, Okayama A, Stuver S, Matsuoka M, Mueller N, Aoki M, et al. Genetic evidence of transmission of human T cell lymphotropic virus type 1 between spouses. J Infect Dis 2002 Mar 1;185(5):691-5.
  6. Laurentino RV, Lopes IG, Azevedo VN, Machado LF, Moreira MR, Lobato L, et al. Molecular characterization of human T-cell lymphotropic virus coinfecting human immunodeficiency virus 1 infected patients in the Amazon region of Brazil. Mem Inst Oswaldo Cruz 2005 Jul;100(4):371-6.
  7. Brites C, Sampalo J, Oliveira A. HIV/human T-cell lymphotropic virus coinfection revisited: impact on AIDS progression. AIDS Rev 2009 Jan;11(1):8-16.
  8. Pereyra F, Addo MM, Kaufmann DE, Liu Y, Miura T, Rathod A, et al. Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J Infect Dis 2008 Feb 15;197(4):563-71.
  9. Hisada M, Maloney EM, Sawada T, Miley WJ, Palmer P, Hanchard B, et al. Virus markers associated with vertical transmission of human T lymphotropic virus type 1 in Jamaica. Clin Infect Dis 2002 Jun 15;34(12):1551-7.
  10. Gotuzzo E, Arango C, de Queiroz-Campos A, Isturiz RE. Human T-cell lymphotropic virus-I in Latin America. Infect Dis Clin North Am 2000 Mar;14(1):211-xi.
  11. Kaplan JE, Osame M, Kubota H, Igata A, Nishitani H, Maeda Y, et al. The risk of development of HTLV-I-associated myelopathy/tropical spastic paraparesis among persons infected with HTLV-I. J Acquir Immune Defic Syndr 1990;3(11):1096-101.
  12. de TG, Bomford R. An HTLV-I vaccine: why, how, for whom? AIDS Res Hum Retroviruses 1993 May;9(5):381-6.
  13. Orland JR, Wang B, Wright DJ, Nass CC, Garratty G, Smith JW, et al. Increased mortality associated with HTLV-II infection in blood donors: a prospective cohort study. Retrovirology 2004 Mar 24;1:4.:4.
  14. Roucoux DF, Murphy EL. The epidemiology and disease outcomes of human T-lymphotropic virus type II. AIDS Rev 2004 Jul;6(3):144-54.
  15. Nagai M, Brennan MB, Sakai JA, Mora CA, Jacobson S. CD8(+) T cells are an in vivo reservoir for human T-cell lymphotropic virus type I. Blood 2001 Sep 15;98(6):1858-61.
  16. Pando MA, Bautista CT, Maulen S, Duranti R, Marone R, Rey J, et al. Epidemiology of human immunodeficiency virus, viral hepatitis (B and C), treponema pallidum, and human T-cell lymphotropic I/II virus among men who have sex with men in Buenos Aires, Argentina. Sex Transm Dis 2006 May;33(5):307-13.
  17. Alavi S, Etemadi A. HIV/HBV, HIV/HCV And HIV/HTLV-1 Coinfection among Injection Drug User Patients Hospitalized at the Infectious Disease Ward of A Training Hospital in Iran. Pak J Med Sci 2007 Apr;23(4):510-3.
  18. Farid R, Etemadi M, Baradaran H, Nikkin B. Seroepidemiology and Virology of HTLV-1 in the City of Mashhad, Northeastern Iran. Serodiagn Immuonother Infect Dis 1993;5(4):251-2.
  19. Arjmand B, Aghayan SH, Goodarzi P, Farzanehkhah M, Mortazavi SM, Niknam MH, et al. Seroprevalence of human T lymphtropic virus (HTLV) among tissue donors in Iranian tissue bank. Cell Tissue Bank 2009 Aug;10(3):247-52.
  20. Khameneh ZR, Sepehrvand N, Masudi S, Taghizade-Afshari A. Seroprevalence of HTLV-1 among kidney graft recipients: a single-center study. Exp Clin Transplant 2010 Jun;8(2):146-9.
  21. Abbaszadegan MR, Gholamin M, Tabatabaee A, Farid R, Houshmand M, Abbaszadegan M. Prevalence of human T-lymphotropic virus type 1 among blood donors from Mashhad, Iran. J Clin Microbiol 2003 Jun;41(6):2593-5.
  22. Rouet F, Rabier R, Foucher C, Chancerel B, Agis F, Strobel M. Geographical clustering of human T-cell lymphotropic virus type I in Guadeloupe, an endemic Caribbean area. Int J Cancer 1999 May 5;81(3):330-4.
  23. Seirafi H, Farnaghi F, Firooz A, Mostafa S, Talaei-Khoei M, Davari P, et al. Comparison of seropositivity of human T lymphotropic virus type 1 in mycosis fungoides patients and normal volunteers: a case-control study and review of literature. Indian J Dermatol Venereol Leprol 2009 Jul;75(4):363-7.
  24. Magalhaes T, Mota-Miranda AC, Alcantara LC, Olavarria V, Galvao-Castro B, Rios-Grassi MF. Phylogenetic and molecular analysis of HTLV-1 isolates from a medium sized town in northern of Brazil: tracing a common origin of the virus from the most endemic city in the country. J Med Virol 2008 Nov;80(11):2040-5.

  • Receive Date 01 April 2011
  • Accept Date 12 June 2011

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