Iranian Journal of Pathology

The Effect of Two Different Doses of Atorvastatin on Lipoprotein-A on Patients with Acute Coronary Syndrome

Document Type : Original Research

Authors

Amirfarhang Zand Parsa 1
Sara Ashoori 1
Alireza Abdollahi 2

1 Dept. of Cardiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

2 Dept. of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Abstract
Background and Objectives: Lipoprotein-a potentially represents a useful tool for risk stratification in cardiovascular accidents.  The aim of this study was to evaluate the atorvastatin effect on serum lipid profile & lipoprotein A.
Material & Methods: In 2009, 405 patients with acute coronary syndrome randomly were divided into 2 groups, taking 20 & 40 mg atorvastatin daily for 3 months. Lipid profile & lipoprotein-A serum levels were checked at the beginning of the study and also one and three months later.
Results: There was no statistical difference between the two groups in all measurements except in patients with unstable angina. The difference lay in the change of LP-a level after one month (P=0.045) and in apo-A level in all patients in the second and the third measurements compared with the first one (P=0.001 & P=0.002).
Discussion: It appears that the two doses (20mg and 40mg) of atorvastatin have a reduction effect on lipoprotein-A and serum lipid levels, but no difference is seen in the level of reduction. The 40 mg atorvastatin leaves more effects on reduction of apo-A than on the 20 mg after one and three months.

Keywords

Atorvastatin calcium
Lipoprotein A
Acute Coronary Syndromes
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Iranian Journal of Pathology
Volume 7, Issue 2 - Serial Number 2
Spring 2012
Pages 101-106

  • Receive Date 10 June 2011
  • Accept Date 09 October 2011

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