Iranian Journal of Pathology

Serum Uric Acid Level and Metabolic Syndrome in Patients Undergoing Coronary Angiography

Document Type : Original Research

Authors

Maryam Sotoudeh Anvari 1
Mohammad Ali Boroumand 1
Mahmood Sheikhfathollahi 2
Leila Pourgholi 1
Hamidreza Goodarzynejad 3

1 Dept. of Surgical and Clinical Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

2 Dept. of Biostatistics , Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

3 Dept. of Research , Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract
Background and Objectives: The association between metabolic syndrome (MetS) and hyperuricemia has been formerly studied mostly in healthy people in western countries. We tried to examine the relationship betweenhyperuricemia and MetS in an Iranian population undergoing coronary angiography.
Materials and Methods: From March 2008 to September 2008, we studied 465 patients (260 men, 55.9%) undergoing elective coronary angiography due to symptoms related to coronary artery disease. The MetS was defined according to the adapted Adult Treatment Panel III (ATP-III A), and hyperuricemia was defined as serum uric acid concentrations ≥ 7.0 mg/dl in men and ≥ 6.0 mg/dl in women. For the statistical analysis, the statistical software SPSS version 13.0 and the statistical package SAS version 9.1 were applied
Results: The mean age of the study population was 59.66 ± 10.04, ranging from 31 to 85 years. Hyperuricemia was detected in 231 (49.7%) of total population, in 126 (54.5%) of men, and in 105 (45.5%) of women. In the multivariable adjusted model, subjects with MetS and subjects with 5 components of the MetS compared to those without any components of the MetS, had 1.56-fold and 4.19-fold increased odds of hyperuricemia, respectively. Hyperuricemia was significantly associated with elevated BP and low level of HDL-cholesterolbut not with other components of MetS.
Conclusions: Our study demonstrated that hyperuricemia was strongly associated with the prevalence of MetS according to adapted ATP III guidelines in an Iranian sample of patients undergoing coronary angiography.
 

Keywords

Metabolic Syndrome X
Hyperuricemia
Coronary Angiographies
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Iranian Journal of Pathology
Volume 7, Issue 2 - Serial Number 2
Spring 2012
Pages 92-100

  • Receive Date 14 May 2011
  • Accept Date 09 October 2011

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