Iranian Journal of Pathology

A Case of Epithelial Myoepithelial Carcinoma – Correlation of IHC & Histopathological Findings

Document Type : Case Reports

Authors

Atul Shrivastav 1
Umang V. Patel 1
Sanjay Gandhi 2
Harsh A. Shah 3

1 Dept. of Pathology, C. U. Shah Medical College, Surendranagar, India

2 Green Cross Pathology and Molecular Laboratory, Ahmedabad, India

3 Dept. of pathology, Shri M.P. Shah Medical college, Jamnagar, India

Abstract
Epithelial myoepithelial carcinoma is a rare biphasic low grade neoplasm of salivary glands; it most commonly occurs in the parotid gland but can also arise in minor salivary glands. Here a case of 58-year-old female presented with left cheek swelling of one-year duration. CT scan revealed a localized submandibular salivary gland tumor mass not involving surrounding tissues. Histological examination showed a mixture of ductal elements; cuboidal cells bordering small lumina surrounded by polygonal clear cells of myoepithelial component without any evidence of nuclear atypia or mitotic figures. Final diagnosis of epithelial myoepithelial carcinoma was made on the basis of characteristic morphological and immunohistochemical features.
 

Keywords

Epithelial- myoepithelial Carcinoma
Salivary Gland
Case Report
  1. Donath K, Seifert G,Schmitz R. Diagnosis and ultrastructure of the tubular carcinoma of salivary gland ducts. Epithelial-myoepithelial carcinoma of the intercalated ducts. Virchows Arch A Pathol Pathol Anat 1972; 356(1):16-31.
  2. Auclair PL, Ellis GL and Gnepp DR. Surgical Pathology of the Salivary Glands. 4th ed. Philadelphia:Saunders;1991.
  3. Corridan M. Glycogen-rich clear cell adenoma of the parotid gland. J Pathol Bacteriol 1956; 72:623-6.
  4. Maurer MH, Gartenslager S, Dietrich C. Giant epithelial-myoepithelial Carcinoma of the parotid gland. Clin Imaging 2009;33:237-9.
  5. Teppo H, Paronen I. Epithelial-myoepithelial carcinoma in minor salivary gland of the hard palate. J Craniofac Surg 2008;19:1689-91.
  6. Fonseca I, Felix A and Soares J. Dedifferentiation in salivary gland carcinomas. Am J Surg Pathol 2000;24(3):469-71.
  7. Bakshi J, Budhiraja G, Gupta K, Patro SK, Gupta N. Epithelial-Myoepithelial Carcinoma of Parotid Gland - A Surprising Clinical Entity. Surg Sci 2012;3:274-8.
  8. Ramraje SN, Bharambe BM, Zode R. Epithelial- myoepithelial carcinoma of the submandibular salivary gland. Bombay Hosp J 2010;52(1):141-3.
  9. Stewart CJ, MacKenzie K, McGarry GW, Mowat A. Fine-needle aspiration cytology of salivary gland: a review of 341 cases. Diagn Cytopathol 2000;22:139–46.
  10. Seethala RR, Barnes EL, Hunt JL. Epithelialmyoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumours of the salivary glands and upper aerodigestive tract. Am J Surg Pathol 2007;31(1): 44-57.
  11. Scarpellini F, Marucci G, Foschini MP. Myoepithelial differentiation markers in salivary gland neoplasia. Pathologica 2001;93(6): 662-7.
  12. Batsakis JG, El-Naggar AK. Pathology consultation: sebaceous lesions of salivary glands and oral cavity. Ann Otol Rhinol Laryngol 1990;99(5 Pt 1):416-8.
  13. Simpson RH, Clarke TJ, Sarsfield PT ,Gluckman PG. Epithelial-Myoepithelial Carcinoma of Salivary Glands. J Clin Pathol 1991;44(5):419-23.
  14. Mahapatra S. Epithelial-Myoepithelial Carcinoma of Parotid-A Rare Case Report. WebmedCentral PATHOLOGY 2011; 2(12):WMC002566 (accessed on 15 Feb 2013).

  • Receive Date 19 December 2012
  • Accept Date 05 May 2013

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